The Young Stellar Population of IC1613. I. A New Catalogue of OB Associations

Context: Determining the parameters of massive stars is crucial to understand many processes in galaxies and the Universe, since these objects are important sources of ionization, chemical enrichment and momentum. 10m class telescopes enable us to perform detailed quantitative spectroscopic analyses of massive stars in other galaxies, sampling areas of different metallicity. Relating the stars to their environment is crucial to understand the physical processes ruling their formation and evolution. Aims: In preparation for the GTC, our goal is to build a catalogue of massive star candidates in the metal-poor irregular galaxy IC1613 with high astrometric accuracy, apt for the current generation of multi-object spectrographs. A census of OB associations in this galaxy is also needed, to provide important additional information about age and environment of the candidate OB stars. Methods: From INT-WFC observations, we have built an astrometric and photometric catalogue of stars in IC1613. Candidate blue massive stars are preselected from their colors. A friends-of-friends algorithm is developed to find their clustering in the galaxy. While a common physical origin for all the members of the associations cannot be ensured, this is a necessary first step to place candidate OB stars in a population context. Results: We have produced a deep catalogue of targets in IC1613 that covers a large field of view. To achieve high astrometric accuracy a new astrometric procedure is developed for the INT-WFC data. We have also built a catalogue of OB associations in IC1613. We have found that they concentrate in the central regions, specially in the HII bubbles. The study of extinction confirms that it is patchy, with local values of color-excess above the foreground value.Comment: Accepted for publication in Astronomy and Astrophysics. 16 pages + appendix (14 pages); 20 figure

Detailed Kinematic Study of the Ionized and Neutral Gas in the Complex of Star Formation in the Galaxy IC 1613

We carried out detailed kinematic studies of the complex of multiple HI and HII shells that represent the only region of ongoing star formation in the dwarf irregular galaxy IC 1613. We investigated the ionized-gas kinematics by using Fabry--Perot H-alpha observations with the 6-m Special Astrophysical Observatory telescope and the neutral-gas kinematics by using VLA 21-cm radio observations. We identified three extended (300-350 pc) neutral shells with which the brightest HII shells in the complex of star formation are associated. The neutral-gas kinematics in the complex has been studied for the first time and the H~I shells were found to expand at a velocity of 15--18 km/s. We constructed velocity ellipses for all HII shells in the complex and refined (increased) the expansion velocities of most of them. The nature of the interacting ionized and neutral shells is discussed.Comment: 14 pages, 9 EPS-figure

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference