Asymptomatic acute brain lesions in AQP4-IgG seropositive patients with NMOSD during an acute attack of optic neuritis or myelitis.

<p>Examples of acute hyperintense lesions in the deep white matter (Aa), periependymal lining of the lateral ventricle (Ba), corpus callosum (Ca), and internal capsule (Da) on T2/fluid-attenuated inversion recovery (FLAIR) images during an acute attack of optic neuritis or myelitis. Note that lesions were markedly decreased in size or resolved on follow-up brain magnetic resonance images (Ab, Bb, Cb, Db). Example of a hyperintense lesion on FLAIR images with a high signal on diffusion-weighted images observed in the left periependymal lining of the lateral ventricle (Ea,Eb) and hypothalamus (Fa,Fb).</p

Chronic cystic changes of brain lesions on MRI.

<p>At the time of an acute brain attack, brain MRI showed multiple T2-hyperintense lesions with subtle T1 hypointensity in the frontal white matter (Aa), corticospinal tract (Ba, Ca), occipital white matter (Da) and corpus callosum (Ea). On follow-up MRI, all T2 hyperintense lesions were markedly decreased in size but revealed focal T1-hypointensity with cystic changes (Ab, Bb, Cb, Db, Eb).</p

Most acute brain lesions in the white matter (Aa, Ba) showed a decrease in size and/or faded.

<p>Most remnant hyperintense lesions in hemispheric white matter on T2/FLAIR images were irregular in shape and located mainly in the subcortical/deep white matter (Ab, Bb). Acute hyperintense lesions in the bilateral hypothalamus (Ca) and around the fourth ventricle and cerebellum (Da, Ea), basal ganglia, and cortical/subcortical (Fa) on T2/FLAIR images resolved completely on follow-up brain MRI (Cb, Db, Eb, Fb).</p

Lesion distribution and chronic changes in brain lesion size on T2-weighted images.

<p>Abbreviations: F, frontal lobe; P-O, parieto-occipital lobe; T, temporal lobe; T2-WI, T2-weighed images; n, number.</p><p>Lesion distribution and chronic changes in brain lesion size on T2-weighted images.</p

Focal atrophy on follow-up brain MRI.

<p>Acute lesions in crus cerebri (Aa) and corpus callosum (Ba) revealed focal atrophy with remnant T2-hyperintense lesions on chronic MRI (Ab, Bb).</p

Lesion distribution and chronic changes in signal intensity of T1-weighted images.

<p>Abbreviations: F, frontal lobe; P-O, parieto-occipital lobe; T, temporal lobe; iso, iso-signal intensity; n, number.</p><p>Lesion distribution and chronic changes in signal intensity of T1-weighted images.</p