Connecting Gas Dynamics and Star Formation Histories in Nearby Galaxies: The VLA-ANGST Survey

In recent years, HST revolutionized the field of star formation in nearby galaxies. Due to its high angular resolution it has now become possible to construct star formation histories of individual stellar populations on scales of a few arcseconds spanning a range of up to ~600 Myr. This method will be applied to the ANGST galaxies, a large HST volume limited survey to map galaxies up to distances of 3.5-4.0 Mpc (excluding the Local Group). The ANGST sample is currently followed--up by high, ~6'' resolution VLA observations of neutral, atomic hydrogen (HI) in the context of VLA-ANGST, an approved Large VLA Project. The VLA resolution is well matched to that of the spatially resolved star formation history maps. The combination of ANGST and VLA-ANGST data will provide a new, promising approach to study essential fields of galaxy evolution such as the triggering of star formation, the feedback of massive stars into the interstellar medium, and the structure and dynamics of the interstellar medium.Comment: to appear in the proceedings to the conference: "The Evolution of Galaxies through the Neutral Hydrogen Window", Arecibo, PR, US

Constraining the age of the NGC 4565 HI Disk Warp: Determining the Origin of Gas Warps

We have mapped the distribution of young and old stars in the gaseous HI warp of NGC 4565. We find a clear correlation of young stars (<600 Myr) with the warp, but no coincident old stars (>1 Gyr), which places an upper limit on the age of the structure. The formation rate of the young stars, which increased ~300 Myr ago relative to the surrounding regions, is (6.3 +2.5/-1.5) x 10^-5 M_sol/yr/kpc^2. This implies a ~60+/-20 Gyr depletion time of the HI warp, similar to the timescales calculated for the outer HI disks of nearby spiral galaxies. While some stars associated with the warp fall into the asymptotic giant branch (AGB) region of the color magnitude diagram, where stars could be as old as 1 Gyr, further investigation suggests that they may be interlopers rather than real AGB stars. We discuss the implications of these age constraints for the formation of HI warps, and the gas fueling of disk galaxies.Comment: 12 pages, 9 figures. Accepted for publication in Ap

A system for phenotype harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) program

Genotype-phenotype association studies often combine phenotype data from multiple studies to increase statistical power. Harmonization of the data usually requires substantial effort due to heterogeneity in phenotype definitions, study design, data collection procedures, and data-set organization. Here we describe a centralized system for phenotype harmonization that includes input from phenotype domain and study experts, quality control, documentation, reproducible results, and data-sharing mechanisms. This system was developed for the National Heart, Lung, and Blood Institute’s Trans-Omics for Precision Medicine (TOPMed) program, which is generating genomic and other -omics data for more than 80 studies with extensive phenotype data. To date, 63 phenotypes have been harmonized across thousands of participants (recruited in 1948–2012) from up to 17 studies per phenotype. Here we discuss challenges in this undertaking and how they were addressed. The harmonized phenotype data and associated documentation have been submitted to National Institutes of Health data repositories for controlled access by the scientific community. We also provide materials to facilitate future harmonization efforts by the community, which include 1) the software code used to generate the 63 harmonized phenotypes, enabling others to reproduce, modify, or extend these harmonizations to additional studies, and 2) the results of labeling thousands of phenotype variables with controlled vocabulary terms.Peer ReviewedPostprint (published version

The Formation of Kiloparsec-scale HI Holes in Dwarf Galaxies

The origin of kpc-scale holes in the atomic hydrogen (H i) distributions of some nearby dwarf irregular galaxies presents an intriguing problem. Star formation histories (SFHs) derived from resolved stars give us the unique opportunity to study past star-forming events that may have helped shape the currently visible Hi distribution. Our sample of five nearby dwarf irregular galaxies spans over an order of magnitude in both total Hi mass and absolute B-band magnitude and is at the low-mass end of previously studied systems. We use Very Large Array Hi line data to estimate the energy required to create the centrally dominant hole in each galaxy. We compare this energy estimate to the past energy released by the underlying stellar populations computed from SFHs derived from data taken with the Hubble Space Telescope. The inferred integrated stellar energy released within the characteristic ages exceeds our energy estimates for creating the holes in all cases, assuming expected efficiencies. Therefore, it appears that stellar feedback provides sufficient energy to produce the observed holes. However, we find no obvious signature of single star-forming events responsible for the observed structures when comparing the global SFHs of each galaxy in our sample to each other or to those of dwarf irregular galaxies reported in the literature. We also fail to find evidence of a central star cluster in FUV or Hα imaging. We conclude that large Hi holes are likely formed from multiple generations of star formation and only under suitable interstellar medium conditions

Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program

Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown. Here we utilized whole genome sequencing data in ancestrally diverse participants of the NHLBI Trans Omics for Precision Medicine program (N = 50,675) to detect structural variants associated with hematologic traits. Using single variant tests, we assessed the association of common and rare structural variants with red cell-, white cell-, and platelet-related quantitative traits and observed 21 independent signals (12 common and 9 rare) reaching genome-wide significance. The majority of these associations (N = 18) replicated in independent datasets. In genome-editing experiments, we provide evidence that a deletion associated with lower monocyte counts leads to disruption of an S1PR3 monocyte enhancer and decreased S1PR3 expression