7 research outputs found
Human papillomavirus (HPV) genotype distribution in penile carcinoma: Association with clinic pathological factors
<div><p>Background</p><p>Penile carcinoma (PC) is a rare, highly mutilating disease, common in developing countries. The evolution of penile cancer includes at least two independent carcinogenic pathways, related or unrelated to HPV infection.</p><p>Objectives</p><p>To estimate the prevalence, identify HPV genotypes, and correlate with clinicopathological data on penile cancer.</p><p>Methods</p><p>A retrospective cohort study involving 183 patients with PC undergoing treatment in a referral hospital in Goiânia, Goiás, in Midwestern Brazil, from 2003 to 2015. Samples containing paraffin embedded tumor fragments were subjected to detection and genotyping by INNO-LiPA HPV. The clinicopathological variables were subjected to analysis with respect to HPV positivity and used prevalence ratio (PR), adjusted prevalence ratio (PRa) and 95% confidence interval (CI) as statistical measures.</p><p>Results</p><p>The prevalence of HPV DNA in PC was 30.6% (95% CI: 24.4 to 37.6), high-risk HPV 24.9% (95% CI: 18.9 to 31.3), and 62.5% were HPV 16. There was a statistical association between the endpoints HPV infection and HPV high risk, and the variable tumor grade II-III (p = 0.025) (p = 0.040), respectively. There was no statistical difference in disease specific survival at 10 years between the HPV positive and negative patients (p = 0.143), and high and low risk HPV (p = 0.325).</p><p>Conclusions</p><p>The prevalence of HPV infection was 30.6%, and 80.3% of the genotypes were identified as preventable by anti-HPV quadrivalent or nonavalent vaccine. HPV infections and high-risk HPV were not associated with penile carcinoma prognosis in this study.</p></div
Curve of survival of patients positive and negative for HPV.
<p>Curve of survival of patients positive and negative for HPV.</p
Descriptive analysis of clinical variables in patients with penile carcinoma in Goiania, Goias, Brazil.
<p>Descriptive analysis of clinical variables in patients with penile carcinoma in Goiania, Goias, Brazil.</p
Prevalence of HPV-DNA in 183 cases of penile carcinoma in a referral hospital in Goias, Brazil.
<p>Prevalence of HPV-DNA in 183 cases of penile carcinoma in a referral hospital in Goias, Brazil.</p
Bivariate and multivariate analysis of factors associated with infection by high-risk HPV.
<p>Bivariate and multivariate analysis of factors associated with infection by high-risk HPV.</p
Survival curve of the patients in relation to HPV positivity and negativity low and high risk.
<p>Survival curve of the patients in relation to HPV positivity and negativity low and high risk.</p