1 research outputs found
Plum pudding random medium model of biological tissue toward remote microscopy from spectroscopic light scattering
Biological tissue has a complex structure and exhibits rich spectroscopic
behavior. There is \emph{no} tissue model up to now able to account for the
observed spectroscopy of tissue light scattering and its anisotropy. Here we
present, \emph{for the first time}, a plum pudding random medium (PPRM) model
for biological tissue which succinctly describes tissue as a superposition of
distinctive scattering structures (plum) embedded inside a fractal continuous
medium of background refractive index fluctuation (pudding). PPRM faithfully
reproduces the wavelength dependence of tissue light scattering and attributes
the "anomalous" trend in the anisotropy to the plum and the powerlaw dependence
of the reduced scattering coefficient to the fractal scattering pudding. Most
importantly, PPRM opens up a novel venue of quantifying the tissue architecture
and microscopic structures on average from macroscopic probing of the bulk with
scattered light alone without tissue excision. We demonstrate this potential by
visualizing the fine microscopic structural alterations in breast tissue
(adipose, glandular, fibrocystic, fibroadenoma, and ductal carcinoma) deduced
from noncontact spectroscopic measurement