4 research outputs found
Influência dos neuroesteróides sobre a tolerância ao etanol em camundongos /
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas
Estudo de fatores envolvidos na modulação da tolerância aos efeitos do álcool por neuroesteróides
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia
Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids
Effect of isopregnanolone on rapid tolerance to the anxiolytic effect of ethanol
OBJETIVE: It has been shown that neurosteroids can either block or stimulate the development of chronic and rapid tolerance to the incoordination and hypothermia caused by ethanol consumption. The aim of the present study was to investigate the influence of isopregnanolone on the development of rapid tolerance to the anxiolytic effect of ethanol in mice. METHOD: Male Swiss mice were pretreated with isopregnanolone (0.05, 0.10 or 0.20 mg/kg) 30 min before administration of ethanol (1.5 g/kg). Twenty-four hours later, all animals we tested using the plus-maze apparatus. The first experiment defined the doses of ethanol that did or did not induce rapid tolerance to the anxiolytic effect of ethanol. In the second, the influence of pretreatment of mice with isopregnanolone (0.05, 0.10 or 0.20 mg/kg) on rapid tolerance to ethanol (1.5 g/kg) was studied. CONCLUSIONS: The results show that pretreatment with isopregnanolone interfered with the development of rapid tolerance to the anxiolytic effect of ethanol