V Jornadas de investigación científica en odontología. Libro de resúmenes

Autoridades. Comision Organizadora. Programa. Mesa De Discusión. Biología Bucal Y Biología Del Desarrollo. Patología Bucal. Tecnología Odontológica. Educación. Prevención Y Aspectos. Psicosociales De La Odontología

Desarrollo de un programa informático para estudios nutricionales Development of a software program for nutrition studies

Se desarrolló el programa informático Interfood v. 1.3 para procesar la información alimentaria y generar datos sobre el consumo dietético -en términos de alimentos, nutrientes y sustancias fitoquímicas- válidos para realizar estudios nutricionales y epidemiológicos. El programa se basa en tres componentes fundamentales: el cuestionario de frecuencia de consumo alimentario (CFCA); una base de datos de alimentos frecuentes y su contenido en 131 compuestos (macro y micronutrientes y sustancias fitoquímicas); y una base de datos relacional que asocia la información del CFCA con la base de datos de alimentos. De esta forma, el programa informático Interfood calcula la cantidad de cada uno de los alimentos y los nutrientes y las sustancias fitoquímicas que una persona consume por día, semana y mes. Interfood es un programa de código abierto, por lo que sus bases de datos se pueden modificar y actualizar de acuerdo con las necesidades de la investigación. Este programa ya ha demostrado su utilidad en diversas investigaciones nutricionales y epidemiológicas.The Interfood v. 1.3 software program was developed to process nutrition information and generate data on dietary intakes-in terms of food, nutrients, and phytochemical substances-valid for conducting studies on nutrition and epidemiology. The program has three basic components: the dietary intake frequency questionnaire CFCA); a database of common foods and their composition of 131 possible substances (macro- and micronutrients and phytochemicals); and a relational database that links the CFCA data with the food database. In this manner, the Interfood software program calculates the amount of food, nutrients, and phytochemical substances consumed by an individual daily, weekly, and monthly. Interfood is an open-source program; as such, the database can be modified and updated according to study requirements. This program has already proven useful to various studies of nutrition and epidemiology

Beef consumption and fatty acids serum concentration: relationship with salivary gland tumors in Córdoba, Argentina

The objective of the present study was to analyze beef consumption, conjugated linoleic acid (CLA) and n-3 fatty acid (FA) serum concentration and their relation to salivary gland tumors (SGT). A questionnaire on non-nutritional risk factors and a validated food frequency questionnaire were applied in 20 SGT and 20 control (Co) patients. Materials and Methods: Food data were processed by the Interfood v.1.3 software. Serum CLA was analyzed by chromatography. Results: Non-significant differences were found between SGT and Co regarding lean and fatty BC and serum CLA. Serum n-3 linolenic acid concentration was higher in Co than in SGT (p=0.004). No associations between BC and CLA serum concentration were found, but a strong-positive association between total energy intake and total fat intake and SGT were observed. A significant inverse association between oleic and linoleic FA intake and SGT was recorded. Conclusion: Serum oleic and linolenic FAs showed a significant negative association with SGT.http://ar.iiarjournals.org/content/34/10/5579.long#sec-3publishedVersionFil: Cittadini, María C. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina.Fil: Cornaglia, Paola M. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Estadística y Demografía; Argentina.Fil: Joekes, Silvia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Estadística y Demografía; Argentina.Fil: Perovic, Nilda R. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina.Fil: Heinze, Verónica M. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina.Fil: Bernal, Claudio. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina.Fil: Actis, Adriana B. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Fil: Actis, Adriana B. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Otras Ciencias de la Salu

Beef consumption and fatty acids serum concentration: relationship with salivary gland tumors in Córdoba, Argentina

The objective of the present study was to analyze beef consumption, conjugated linoleic acid (CLA) and n-3 fatty acid (FA) serum concentration and their relation to salivary gland tumors (SGT). A questionnaire on non-nutritional risk factors and a validated food frequency questionnaire were applied in 20 SGT and 20 control (Co) patients. Materials and Methods: Food data were processed by the Interfood v.1.3 software. Serum CLA was analyzed by chromatography. Results: Non-significant differences were found between SGT and Co regarding lean and fatty BC and serum CLA. Serum n-3 linolenic acid concentration was higher in Co than in SGT (p=0.004). No associations between BC and CLA serum concentration were found, but a strong-positive association between total energy intake and total fat intake and SGT were observed. A significant inverse association between oleic and linoleic FA intake and SGT was recorded. Conclusion: Serum oleic and linolenic FAs showed a significant negative association with SGT.http://ar.iiarjournals.org/content/34/10/5579.long#sec-3publishedVersionFil: Cittadini, María C. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina.Fil: Cornaglia, Paola M. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Estadística y Demografía; Argentina.Fil: Joekes, Silvia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Estadística y Demografía; Argentina.Fil: Perovic, Nilda R. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina.Fil: Heinze, Verónica M. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina.Fil: Bernal, Claudio. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina.Fil: Actis, Adriana B. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Fil: Actis, Adriana B. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Otras Ciencias de la Salu

Initial invasive or conservative strategy for stable coronary disease

BACKGROUND Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, 121.8 percentage points; 95% CI, 124.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used

Health-status outcomes with invasive or conservative care in coronary disease

BACKGROUND In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS We assessed angina-related symptoms, function, and quality of life with the Seattle Angina Questionnaire (SAQ) at randomization, at months 1.5, 3, and 6, and every 6 months thereafter in participants who had been randomly assigned to an invasive treatment strategy (2295 participants) or a conservative strategy (2322). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate differences between the treatment groups. The primary outcome of this health-status analysis was the SAQ summary score (scores range from 0 to 100, with higher scores indicating better health status). All analyses were performed in the overall population and according to baseline angina frequency. RESULTS At baseline, 35% of patients reported having no angina in the previous month. SAQ summary scores increased in both treatment groups, with increases at 3, 12, and 36 months that were 4.1 points (95% credible interval, 3.2 to 5.0), 4.2 points (95% credible interval, 3.3 to 5.1), and 2.9 points (95% credible interval, 2.2 to 3.7) higher with the invasive strategy than with the conservative strategy. Differences were larger among participants who had more frequent angina at baseline (8.5 vs. 0.1 points at 3 months and 5.3 vs. 1.2 points at 36 months among participants with daily or weekly angina as compared with no angina). CONCLUSIONS In the overall trial population with moderate or severe ischemia, which included 35% of participants without angina at baseline, patients randomly assigned to the invasive strategy had greater improvement in angina-related health status than those assigned to the conservative strategy. The modest mean differences favoring the invasive strategy in the overall group reflected minimal differences among asymptomatic patients and larger differences among patients who had had angina at baseline