Edens: A 360 degree digital poem

Edens is a 360 degree digital poem exploring the idea of the self in the landscape.N/

How you teach and who you teach both matter: lessons from learning analytics data

To explore potential effects of disadvantage on engagement and attainment under different teaching and assessment regimes, the influence of pedagogic changes implemented during the COVID-19 pandemic on attainment and engagement of students from different backgrounds were compared using a cohort-study design. Learner analytics and attainment data from first year undergraduate students during three learning regimes were compared: (i) in-person teaching and assessment, (ii) in-person teaching with online assessment, and (iii) online teaching and assessment. The gap in end-of-year mark between disadvantaged students and their peers was widest when teaching and assessment was online, with poorer outcomes for disadvantaged students, although the gap in the percentage of students passing all their modules did not change. Overall, online teaching and assessment during the pandemic was associated with a widening attainment gap between disadvantaged students and their peers. Possible explanations for this are discussed, including the relationship between attainment and engagement. Higher Education providers should monitor and review the potential implications of their chosen education strategy on different groups of students: how you teach and who you teach are both important

Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase

Macrophage activation by cytokines or microbial products such as LPS results in the induction and release of several key immune effector molecules including NO and IL-12. These have been shown to play crucial roles in the development of immunity to intracellular pathogens such as Leishmania. The molecular mechanisms underlying the induction of these effector molecules are not fully understood. We now show that the extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases play differential roles in the regulation of LPS-stimulated inducible NO synthase and IL-12 gene expression. In macrophages, LPS stimulates the simultaneous activation of all three classes of MAP kinases, ERK, c-jun N-terminal kinase, and p38, albeit with differential activation kinetics. However, studies using inhibitors selective for ERK (PD98059) and p38 (SB203580) show that while p38 plays an essential role in the induction of inducible NO synthase, ERK MAP kinases play only a minor role in promoting NO generation. In contrast, while p38 promotes induction of IL-12 (p40) mRNA, ERK activation suppresses LPS-mediated IL-12 transcription. The biological relevance of these regulatory signals is demonstrated by our finding that Leishmania lipophosphoglycans, which promote parasite survival, act by stimulating ERK MAP kinase to inhibit macrophage IL-12 production. Thus, as ERK and p38 MAP kinases differentially regulate the induction of the macrophage effector molecules, inducible NO synthase and IL-12, these kinases are potential targets not only for the development of novel strategies to combat intracellular pathogens but also for therapeutic immunomodulation