5 research outputs found
The distribution of reproductive risk factors disclosed the heterogeneity of receptor-defined breast cancer subtypes among Tanzanian women
BACKGROUND: Recent epidemiological studies suggest that reproductive factors are associated with breast cancer (BC) molecular subtypes. However, these associations have not been thoroughly studied in the African populations. The present study aimed to investigate the prevalence of BC molecular subtypes and assess their association with reproductive factors in Tanzanian BC patients. METHODS: This hospital-based case-only cross-sectional study consisted of 263 histologically confirmed BC patients in Tanzania. Clinico-pathological data, socio-demographic characteristics, anthropometric measurements, and reproductive risk factors were examined using the Chi-square test and one-way ANOVA. The association among reproductive factors and BC molecular subtypes was analyzed using multinomial logistic regression. The heterogeneity of the associations was assessed using the Wald test. RESULTS: We found evident subtype heterogeneity for reproductive factors. We observed that post-menopausal status was more prevalent in luminal-A subtype, while compared to luminal-A subtype, luminal-B and HER-2 enriched subtypes were less likely to be found in post-menopausal women (OR: 0.21, 95%CI 0.10â0.41, pâ=â0.001; OR: 0.39, 95%CI 0.17â0.89, pâ=â0.026, respectively). Also, the luminal-B subtype was more likely to be diagnosed in patients aged â€â40 years than the luminal-A subtype (OR: 2.80, 95%CI 1.46â5.32, pâ=â0.002). Women who had their first full-term pregnancy at <â30 years were more likely to be of luminal-B (OR: 2.71, 95%CI 1.18â4.17, pâ=â0.018), and triple-negative (OR: 2.28, 95%CI 1.02â4.07, pâ=â0.044) subtypes relative to luminal-A subtype. Furthermore, we observed that breastfeeding might have reduced odds of developing luminal-A, luminal-B and triple-negative subtypes. Women who never breastfed were more likely to be diagnosed with luminal-B and triple-negative subtypes when compared to luminal-A subtype (OR: 0.46, 95%CI 0.22â0.95, pâ=â0.035; OR: 0.41, 95%CI 0.20â0.85, pâ=â0.017, respectively). . CONCLUSION: Our results are the first data reporting reproductive factors heterogeneity among BC molecular subtypes in Tanzania. Our findings suggest that breast-feeding may reduce the likelihood of developing luminal-A, luminal-B, and triple-negative subtypes. Meanwhile, the first full-term pregnancy after 30 years of age could increase the chance of developing luminal-A subtype, a highly prevalent subtype in Tanzania. More interventions to promote modifiable risk factors across multiple levels may most successfully reduce BC incidence in Africa. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12905-021-01536-6
Association of XRCC1-Arg399Gln and XPG-Asp1104His polymorphisms with reproductive risk factors and increased risk of breast cancer in Tanzanian patients
The interplay between XPGâAsp1104His polymorphism and reproductive risk factors elevates risk of breast cancer in Tanzanian women: A multiple interaction analysis
Abstract Background Reproductive history and genetics are wellâknown risk factors of breast cancer (BC). Little is known about how these factors interact to effect BC. This study investigated the association of ten polymorphisms in DNA repair genes with BC susceptibility in the Tanzanian samples and further analyzed the association between reproductive risk factors and disease risk Methods A hospitalâbased caseâcontrol study in 263 histopathological confirmed BC patients and 250 ageâmatched cancerâfree controls was carried out. Allelic, genotypic, and haplotype association analyses were executed. Also, multifactor dimensionality reduction (MDR), and interaction dendrogram approaches were performed. Results The frequency of genotypic and allelic variants of XRCC1âArg399Gln (rs25487), XRCC2âArg188His (rs3218536), XRCC3âThr241Met (rs861539), XPGâAsp1104His (rs17655), and MSH2âGly322Asp (rs4987188) were significantly different between the groups (pâ<â0.05). Moreover, XRCC1âArg399Gln (rs25487), XRCC3âThr241Met (rs861539), and XPGâAsp1104His (rs17655) were associated with the increased risk of BC in coâdominant, dominant, recessive, and additive geneticâinheritance models (pâ<â0.05). XRCC1âArg/Gln genotype indicated a 3.1âfold increased risk of BC in preâmenopausal patients (p = 0.001) while XPGâHis/His genotype showed a 1.2âfold increased risk in younger BC patients (<40âyears) (p = 0.028). Asp/His+His/His genotypes indicated a 1.3âfold increased risk of BC in PR+ patients and a 1.1âfold decreased risk of BC in luminalâA patients (p = 0.014, p = 0.020, respectively). MDR analysis revealed a positive interaction between BC and the XPGâAsp1104His (rs17655) together with family history of cancer in the firstâdegree relatives. Dendrogram analysis indicated that the XPGâAsp1104His (rs17655) and family history of cancer in firstâdegree relatives were significantly synergistic and might be associated with an elevated risk of BC in Tanzania. Conclusions The XPGâAsp1104His (rs17655) might exert both independent and interactive effects on BC development in the Tanzanian women
Abstracts of Tanzania Health Summit 2020
This book contains the abstracts of the papers/posters presented at the Tanzania Health Summit 2020 (THS-2020) Organized by the Ministry of Health Community Development, Gender, Elderly and Children (MoHCDGEC); President Office Regional Administration and Local Government (PORALG); Ministry of Health, Social Welfare, Elderly, Gender, and Children Zanzibar; Association of Private Health Facilities in Tanzania (APHFTA); National Muslim Council of Tanzania (BAKWATA); Christian Social Services Commission (CSSC); & Tindwa Medical and Health Services (TMHS) held on 25â26 November 2020. The Tanzania Health Summit is the annual largest healthcare platform in Tanzania that attracts more than 1000 participants, national and international experts, from policymakers, health researchers, public health professionals, health insurers, medical doctors, nurses, pharmacists, private health investors, supply chain experts, and the civil society. During the three-day summit, stakeholders and decision-makers from every field in healthcare work together to find solutions to the countryâs and regional health challenges and set the agenda for a healthier future.
Summit Title: Tanzania Health SummitSummit Acronym: THS-2020Summit Date: 25â26 November 2020Summit Location: St. Gasper Hotel and Conference Centre in Dodoma, TanzaniaSummit Organizers: Ministry of Health Community Development, Gender, Elderly and Children (MoHCDGEC); President Office Regional Administration and Local Government (PORALG); Ministry of Health, Social Welfare, Elderly, Gender and Children Zanzibar; Association of Private Health Facilities in Tanzania (APHFTA); National Muslim Council of Tanzania (BAKWATA); Christian Social Services Commission (CSSC); & Tindwa Medical and Health Services (TMHS)