Safety evaluation for packaging (onsite) for concrete-shielded RHTRU waste drum for the 327 postirradiation testing laboratory

This safety evaluation for packaging authorizes onsite transport of Type B quantities of radioactive material in the Concrete- Shielded Remote-Handled Transuranic Waste (RH TRU) Drum per WHC-CM-2-14, Hazardous Material Packaging and Shipping. The drum will be used for transport of 327 Building legacy waste from the 300 Area to the Transuranic Waste Storage and Assay Facility in the 200 West Area and on to a Solid Waste Storage Facility, also in the 200 Area

Empagliflozin in the Treatment of Type 2 Diabetes: Evidence to Date

In the last decade, researchers have gained a greater understanding of the pathophysiologic mechanisms of type 2 diabetes as a chronic and progressive disease. One of the more recent treatment targets is the kidney. The kidneys become maladaptive in diabetes by increasing the reabsorption of glucose above the normal physiologic renal threshold. This discovery has led to the development of the sodium/glucose cotransporter 2 inhibitors (SGLT2). These agents readjust the renal threshold for glucose reabsorption to a lower level and decrease glucose reabsorption, while increasing urinary glucose when the glucose is above the renal threshold and subsequently lowering plasma glucose. The mechanism of action of the SGLT2 inhibitors is insulin independent, which makes them a novel treatment of diabetes. At the time of preparation of this manuscript, there were three SGLT2 inhibitors available in the US. This manuscript focuses on empagliflozin, the newest SGLT2 inhibitor, the trials in its development, and the clinical data available to date. Further, the authors propose future applications of empagliflozin, including in the treatment of type 1 diabetes, and its potential role in renoprotection

Stability and Representation Dependence of the Quantum Skyrmion

A constructive realization of Skyrme's conjecture that an effective pion mass ``may arise as a self consistent quantal effect'' based on an ab initio quantum treatment of the Skyrme model is presented. In this quantum mechanical Skyrme model the spectrum of states with $I=J$, which appears in the collective quantization, terminates without any infinite tower of unphysical states. The termination point depends on the model parameters and the dimension of the SU(2) representation. Representations, in which the nucleon and $\Delta_{33}$ resonance are the only stable states, exist. The model is developed for both irreducible and reducible representations of general dimension. States with spin larger than 1/2 are shown to be deformed. The representation dependence of the baryon observables is illustrated numerically.Comment: 19 pages, Late

SU(2) Skyrme Vortices

A regular method for constructing vortex-like solutions with cylindrical symmetry to the equations of the SU(2) Skyrme chiral model is proposed. A numerical estimate for the length density of mass is given

Procurement of a fully licensed radioisotope thermoelectric generator transportation system

A fully licensed transportation system for Radioisotope Thermoelectric Generators and Light-Weight Radioisotope Heater Units is currently being designed and built. The system will comply with all applicable US Department of Transportation regulations without the use of a DOE Alternative.'' The US Department of Transportation has special double containment'' requirements for plutonium. The system packaging uses a doubly contained bell jar'' concept. A refrigerated trailer is used for cooling the high-heat payloads. The same packaging is used for both high- and low-heat payloads. The system is scheduled to be available for use by mid-1992. 4 refs., 4 figs., 2 tabs

The Single Photon Annihilation Contributions to the Positronium Hyperfine Splitting to Order meα6m_e\alpha^6

The single photon annihilation contributions for the positronium ground state hyperfine splitting are calculated analytically to order $m_e\alpha^6$ using NRQED. Based on intuitive physical arguments the same result can also be determined by a trivial calculation using results from existing literature. Our result completes the hyperfine splitting calculation to order $m_e\alpha^6$. We compare the theoretical prediction with the most recent experimental measurement.Comment: 8 pages, latex, two eps figures include

alpha^2 corrections to parapositronium decay: a detailed description

We present details of our recent calculation of alpha^2 corrections to the parapositronium decay into two photons. These corrections are rather small and our final result for the parapositronium lifetime agrees well with the most recent measurement. Implications for orthopositronium decays are briefly discussed.Comment: 18 pages, late

Interactions of B = 4 Skyrmions

It is known that the interactions of single Skyrmions are asymptotically described by a Yukawa dipole potential. Less is known about the interactions of solutions of the Skyrme model with higher baryon number. In this paper, it is shown that Yukawa multipole theory can be more generally applied to Skyrmion interactions, and in particular to the long-range dominant interactions of the B = 4 solution of the Skyrme model, which models the alpha-particle. A method that gives the quadrupole nature of the interaction a more intuitive meaning in the pion field colour picture is demonstrated. Numerical methods are employed to find the precise strength of quadrupole and octupole interactions. The results are applied to the B = 8 and B = 12 solutions and to the Skyrme crystal.Comment: 21 pages, 11 figure

Soliton quantization and internal symmetry

We apply the method of collective coordinate quantization to a model of solitons in two spacetime dimensions with a global $U(1)$ symmetry. In particular we consider the dynamics of the charged states associated with rotational excitations of the soliton in the internal space and their interactions with the quanta of the background field (mesons). By solving a system of coupled saddle-point equations we effectively sum all tree-graphs contributing to the one-point Green's function of the meson field in the background of a rotating soliton. We find that the resulting one-point function evaluated between soliton states of definite $U(1)$ charge exhibits a pole on the meson mass shell and we extract the corresponding S-matrix element for the decay of an excited state via the emission of a single meson using the standard LSZ reduction formula. This S-matrix element has a natural interpretation in terms of an effective Lagrangian for the charged soliton states with an explicit Yukawa coupling to the meson field. We calculate the leading-order semi-classical decay width of the excited soliton states discuss the consequences of these results for the hadronic decay of the $\Delta$ resonance in the Skyrme model.Comment: 23 pages, LA-UR-93-299

The "recoil" correction of order mα6m \alpha^6 to hyperfine splitting of positronium ground state

The "recoil" correction of order $m \alpha^6$ to the hyperfine splitting of positronium ground state was found. The formalism employed is based on the noncovariant perturbation theory in QED. Equation for two-particle component of full (many-body) wave function is used, in which effective Hamiltonian depends on the energy of a system. The effective Hamiltonian is not restricted to the nonrelativistic region, so there is no need in any regularization. To evaluate integrals over loop momenta, they are divided into "hard" and "soft" parts, coming from large and small momenta respectively. Soft contributions were found analytically, and hard ones are evaluated by numerical integration. Some soft terms due to the retardation cancel each other. To calculate the "hard" contributions, a great number of noncovariant graphs is replaced by only a few covariant ones. The hard contribution was found in two ways. The first way is to evaluate contributions of separate graphs, using the Coulomb gauge. The second one is to calculate full hard contribution as a whole using the Feynman gauge. The final result for the "recoil" correction is 0.381(6) m\al^6 and agrees with those of previous papers. Diagram-to-diagram comparison with the revised results of Adkins&Sapirstein was done. All the results agree, so the "recoil" correction is now firmly established. This means a considerable disagreement with the experimental data.Comment: 28 pages, latex including latex figure