Eco-friendly and versatile brominating reagent prepared from a liquid bromine precursor

Facile bromination of various organic substrates has been demonstrated with a 2 : 1 bromide:bromate reagent prepared from the alkaline intermediate of the conventional bromine recovery process. The reagent is acidified in situ to generate HOBr as the reactive species, which effects bromination. Aromatic substrates that have been successfully brominated under ambient conditions without use of any catalyst include phenols, anilines, aromatic ethers and even benzene. Non-aromatic compounds bearing active methylene group were monobrominated selectively with the present reagent and olefinic compounds were converted into the corresponding bromohydrins in moderate yields. By obtaining the present reagent from the liquid bromine precursor, the twin advantages of avoiding liquid bromine and producing the reagent in a cost-effective manner are realised. When coupled with the additional advantage of high bromine atom efficiency, the present protocol becomes attractive all the way from "cradle to grave"

Green process development for the preparation of 2,6-dibromo-4-nitroaniline from 4-nitroaniline using bromide–bromate salts in an aqueous acidic medium

Organic solvent-free process for the preparation of 2,6-dibromo-4-nitroaniline, from 4-nitroaniline using 2 : 1 bromide–bromate salts under aqueous acidic medium at ambient conditions has been developed.</p

A fast and highly efficient method for the synthesis of tertiary amines in aqueous medium

771-775A facile and highly efficient method for the synthesis of tertiary amines by the reaction of secondary amines with benzylic bromides and 1,1′-dibromo p/o-xylenes in aqueous dioxane and NaOH is described. The reactions are dually promoted by the base in short time (15 min.) at ambient conditions in aqueous medium

An efficient method for the synthesis of 2,3-dihydro-1<i>H</i>-isoindoles

545-552The synthesis of N-substituted 2,3-dihydro-1H-isoindoles from ⍺, ⍺'-dibromo-o-xylene and various primary amines in basic medium under ambient conditions is described. Especially the selection of 1,4-dioxane as solvent and sodium hydroxide as suitable base to maintain the  homogeneity of the medium are key steps to promote the reaction efficiently. Primary alkyl amines react faster as compared to their aromatic analogues under the conditions studied. Irrespective of the starting amine used, all the reactions proceed smoothly and provide 2,3-dihydro-1H-isoindoles derivatives in excellent yields compared to hitherto known methods