False Negative Report of 18F -FDG PET/CT in a Patient with Liver Metastases due to Uveal Melanoma

Background:To report a false negative 18F-Fluorodeoxyglucose (FDG) positron emission tomography/ computed tomography (PET/CT) of liver metastasis in a patient with malignant uveal melanoma. Material and Methods:A 74-year-old man with left eye uveal melanoma and liver metastasis that was found seven months after the enucleation surgery. Results:Seven months post-enucleation surgery, ultrasonography revealed a suspicious hepatic lesion. Further investigation using magnetic resonance imaging (MRI) and PET scan was recommended. MRI with and without contrast reported mild post-contrast enhancement in the right lobe of the liver, suggestive of metastasis from the known tumor of the patient. 18F-FDG PET/CT surprisingly showed no metabolic evidence of malignancy throughout the body. Finally, the patient was scheduled for an ultrasound-guided biopsy. Pathology reported metastatic malignant melanoma. Conclusion:It is important to remember not to rely solely on PET/CT since it may report false negative results in liver metastasis

Retinal Screening of Coats Disease Using Electroretinography

Background: Coats is a retinal disorder causing dilation of blood vessels in the human retina. The present study aims to measure electroretinography (ERG) in patients suffering from Coats disease. Material and Methods: 11 (20 eyes) male patients suffering from Coats were selected for the present study. Electroretinography was measured in the patient group using the Mangoni machine. The result was compared with the 11 (22 eyes) normal population following the ERG test. SPSS version 22 was used for this purpose. Results: The case and control groups were not significantly different in age, while a significant difference was observed in Best corrected visual acuity. BCVA between the two groups. Furthermore ( 110.9±8.63 and 93.09 ± 8.04 in control and case respectively ) , the difference between the mean amplitude of ERG, b wave was statistically significant as far as patient and normal groups were concerned.    Conclusion: Coats disease damages the retina, which can be measured by the amplitude of ERG, b wave

Electrophysiological Eye Examination Changes in a Patient with Sjogren's Syndrome

AbstractSjogren's syndrome is one of the most common autoimmune diseases. It may exist as either a primary syndrome or as a secondary syndrome associated with other autoimmune diseases such as rheumatoid arthritis and systemic sclerosis. Patient with Sjogren's syndrome have certain visual system involvements with dry eye being the most common type. These patients may also exhibit certain pathological changes in their retina and visual pathway.Here we report the electrophysiological recording including visual evoked potential, electro- retinography and electrooculography findings in a patient with Sjogren's syndrome. keywords: Sjogren's Syndrome; Evoked Potentials, Visual; Electro- retinography.