Anticataract activity of ethanolic extract from Hippobroma longiflora (L.) G.Don leaves: Ex vivo investigation

Context: In Aceh, Hippobroma longiflora, known as kitolodby the locals, is believed to possess medicinal benefits such as anticataract. Aims: To investigate the anticataract activity of ethanolic extract from H. longiflora leaves ex vivo. Methods: The dried fine powder of H. longiflora was macerated using ethanol at room temperature, and the concentrated extract was prepared in concentrations ranging from 100 to 300 μg/mL. The cataract model was established by using goat lens induced with H2O2 and later exposed to the extract for treatment. Anti-cataract activity was assessed by observing the change in lens opacity. Further, malondialdehyde levels and activities of endogenous antioxidants (superoxide dismutase, glutathione peroxidase, and catalase). Results: The apparent cataract opacity reduced after the exposure of the extract was observed macroscopically. The cataract eyes experienced a significant increase (p<0.05) in malondialdehyde level and a significant reduction (p<0.05) in the activities of superoxide dismutase, glutathione peroxidase, and catalase. The pathologic conditions could be reversed by introducing the extract with a concentration as low as 100 μg/mL (p<0.05). Conclusions: The ethanolic extract of H. longiflora leaf has a potential anticataract effect by ameliorating oxidative stress-related biocompounds

The Complexity of Handling Posterior Subcapsular Cataract Case

Cataracts or “katarrhakies” in Greek means waterfall. This term is used because the vision in cataract patients is described as a closed waterfall due to the clouding of the lens. PSCs (posterior subcapsular cataracts) might cause symptoms within months. and can cause worse visual disturbances compared to other types of senile cataracts. A 63-year-old man came to the Department of Ophthalmology at RSUD Dr. Zainoel Abidin with a chief complaint of blurry vision in both eyes since two years ago and felt more severe in the left eye. The patient also complained of difficulty seeing an object and reading at close range. On physical examination, a cloudy lens was found in the central posterior part of his both eyes the iris shadow test of both eyes was positive. The patient was diagnosed with posterior subcapsular cataract oculus dexter and sinister (ODS). The patient was planned to undergo phacoemulsification and intraocular lens (IOL) implantation in his left eye. The patient came back in the next couple weeks after surgery and it shows that his left eye visual acuity was 20/20 and the ocular anatomy was in good condition. Nowadays, phacoemulsification is still the first choice in PSC therapy. This type of cataract is difficult to treat because the cataract is still thin and the lens is mostly transparent, but it often causes glare and vision impairment which can interfere with daily activities

BlueBrain/Brayns: 3.2.2 Release

Visualizer for large-scale and interactive ray-tracing of neuron

BlueBrain/Brayns: 3.3.0 Release

Visualizer for large-scale and interactive ray-tracing of neuron

BlueBrain/MorphIO: Allow to throw warnings instead of writing them to stderr/stdout

remove -j2 from cpp_test.sh - not an option for cmake (#269) Adding C++ tests (#263) Fix for compat with recent HighFive (#268) Minimal solution to raising of warning instead of writing them (#266) apply ignoring logic to raised warnings as well (#271) Consider custom section types from 5 up to 10 (#274) fix broken links and include README to readthedocs (#276) narrow conditions when WARNING_NEUROMORPHO_SOMA_NON_CONFORM is thrown (#275