ANNONA MURICATA LINN. ETHANOLIC LEAF EXTRACT AMELIORATES REPRODUCTIVE COMPLICATIONS IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

Diabetes mellitus is an endocrine and metabolic disorder of humans and animals characterized by hyperglycemia and low blood insulin levels or insensitivity of target organs to insulin and it’s a major health problem affecting patient’s quality of life due to its many complications. Infertility is one of the major secondary complications in diabetes. Although numerous drugs have been used for intervention studies on diabetes-induced infertility worldwide, there are currently no treatments for diabetes associated infertility in humans. This study was performed to investigate the effects of Annona muricata ethanolic leaf extract (AMELE) on fertility of male diabetic rats and levels of blood glucose. Twenty male Wistar rats (150-200g) were randomly distributed into 4 groups (n=5) treated thus: CTRL (control), DNT, DT1 and DT2 (diabetic, single intraperitoneal injection, streptozotocin, 60 mg/kg). Group DT1 and DT2 received AMELE orally at 100 mg/kg and 200 mg/kg respectively daily for fourteen days. Data were analysed using ANOVA at α0.05. The animals were sacrificed after 2 weeks via thiopental injection and testicular weights were recorded. Fasting blood glucose was determined using a digital glucometer. Sperm count, motility, viability and morphology were assessed microscopically. Testes were histologically evaluated. The results showed that oral administration of AMELE at 100 mg/kg and 200 mg/kg to diabetic male rats for fourteen days significantly decreased blood glucose level and also ameliorated diabetes-induced decreases in sperm functions in streptozotocin-induced diabetic male rats.   &nbsp

Physicians’ Knowledge of the Glasgow Coma Scale in a Nigerian University Hospital: Is the Simple GCS Still Too Complex?

Objective: The Glasgow Coma Scale, GCS, is a universal clinical means of quantifying the level of impaired consciousness. Although physicians usually receive undergraduate and postgraduate training in the use of this scale in our university hospital we are aware of studies suggesting that the working knowledge of the GCS among practising physicians might not be adequate. Methods: We carried out a questionnaire-based survey across all specialties and levels of training of physicians in active patient care in a Nigerian university hospital. Results: Of the 100 physicians sampled, 98 correctly spelled out what the three-letter abbreviation, GCS, stands for. Ninety-three percent also conceded it to be an important clinical rating scale. However, only 55–89% of the participants correctly identified the three respective clinical variables, (eye opening, verbal response, and motor response), of the GCS. More particularly, the participants’ ability to itemize and correctly score all the respective components of each of the three clinical variables ranged from 0 to 35% across specialties and levels of training. Performance was best for the four-item eye opening variable and, worst for the six-item motor response variable. Conclusion: In our university hospital, practising physicians’ working knowledge of the GCS is inadequate and is dependent on the degree of the complexity of each of the three clinical variables of the scale

PLASMA LIPID PROFILE AND SOME BIOCHEMICAL INDICES IN DOMESTICATED GREATER CANE RAT (Thryonomys swinderianus temminck)

Some serum biochemical parameters and lipid profile indices were determined in eight male adult greater cane rats Thryonomys swinderianus Temminck, raised under intensive management system. Activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in plasma were assayed spectrophotometrically, following venopuncture-blood collection and subsequent separation of plasma. Glucose, total protein, albumin and bilirubin as well as lipid profile indices such as total cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, triglycerides and phospholipids concentration were also determined. In comparison with data from previous studies on wild and captive cane rats, our results indicate lower lipid profile indices and total protein. Activities of hepatic enzymes (AST and ALT) were also lower, while plasma glucose concentration was higher in this third generation greater cane rats. It is concluded that certain aspects of management system in domestication may have a profound influence on biochemical parameters most especially the lower LDL-cholesterol that reduces the risk of atherosclerosis (cardiac disease). This study, therefore offers baseline data for third generation intensively raised greater cane rats.Â

EMERGENCE OF NEW STRAINS OF SARS-COV-2: AFRICA’S FATE AND ITS PREPAREDNESS AGAINST COVID-19 INFECTION WAVES

Background: Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has infected over 100million individuals worldwide with diverse impacts on nations. The rising cases of new strains and resultant infection waves create an urgent need to assess the readiness of countries especially in Africa to mitigate the impact on community transmission. This paper delivers a brief synopsis of the novel SARS-CoV-2, emerging cases of new variants reported worldwide, and implications for genetic surveillance of disease transmission in low-and middle-income countries (LMICs) especially Africa. Materials and Methods: Literature search used keywords like SARS-CoV-2; COVID-19 epidemiology; pandemic waves; corona outbreak, clinical syndromes, treatments, prevention and control. Cross-sectional and observational studies published on COVID-19 from 2019 till date of study provided main information sources. Databases such as Web of Science, Embase, PubMed and Google Scholar were utilised. Main findings: Over 220 countries have documented COVID-19 cases with varied severity till date. Before the spikes in resurgence, a highly virulent mutated (>90% fatality rate) novel strain of COVID-19 had been documented. There is very little data to ascertain the impact of the COVID-19 infection waves in LMICs. Discussion: LMICs especially African countries still grapple with significant challenges like inefficient surveillance mechanisms, inadequate vaccination coverage, inadequate enforcement of environmental health strategies, poor health systems etc. Hence, Africa’s fate remains dicey in the face of the dynamic evolution of the SARS-CoV-2 and other identified challenges. Conclusion:  The adoption of a multidisciplinary approach to mitigate the impact of emergence of mutant SARS-CoV-2 variants and resurgence of infection spike is recommende

Radiological and chemical toxicity risks of uranium in groundwater based-drinking at Immigration Headquarters Gosa and Federal Housing Lugbe area of Abuja, North Central Nigeria

Inadequate public water supply by the Water Board in Abuja has forced the public to source for groundwater as the only alternative for consumption without consideration for radiological risk. The radiological risk for cancer mortality of uranium in Immigration Headquarters Gosa and Federal-Housing Lugbe groundwater water samples were measured and compared with Water Board and hand-dug well water samples from the same area using inductively coupled plasma mass spectrometry. The highest radiological risks for cancer mortality and morbidity were found to be low, with highest values of 1.24 × 10−7 and 1.64 × 10−7 obtained from Federal-Housing Lugbe borehole. The chemical toxicity risk of 238U in drinking water over life time consumption has a mean value of 4.0 × 10−4 μg kg−1 day−1 with highest value of 6.0 × 10−3 μg kg−1 day−1 obtained from Federal-Housing Lugbe. Significantly, this study inferred that the 238U concentrations reported in groundwater based-drinking originated from sheared zone of magmatic metamorphosed basaltic dyke intrusion. Due to the low risk values found in the water samples when compared with the International Reference Standard, radiological and chemical toxicity risks values may not pose any health risk to the public that rely on groundwater in the are

Antispermatogenic Activity Of Morinda Morindoides Root Bark Extract In Male Wistar Rats

To investigate the effect of the aqueous extract of the root bark of Morinda morindoides (Rubiaceae) on the reproductive activity of male Wistar rats, three groups (A, B and C) of six rats each were treated with 400,800 and 1600 mg/kg/day of Morinda morindoides root bark extract respectively for 28 days while 5mls/kg of distilled water was given to the control group D. At the end of the experimental period, animals were sacrificed and sperm characteristics, histology of the testes and epididymis were assessed. Morinda morindoides root bark extract caused a significant reduction (p<0.05) in sperm motility, a significant dose dependent reduction in the sperm count and a significant (p<0.05) dose dependent increase in morphological abnormalities of the spermatozoa of the treated rats. Histopathological evaluation of the testis and epididymis revealed varying degrees of degeneration and necrosis of the germinal epithelia cell of the seminiferous tubules and spermiostasis. Morinda morindoides root bark extract has significant anti-spermatogenic effects on adult male Wistar rats which could impair reproductive activities in these male Wistar rats. &nbsp

African Growth and Opportunity Act and trade performance in Nigeria

This study examines the implementation status of the African Growth Opportunity Act (AGOA) and its performance in Nigeria using socio-economic indicators. Also, the study provides recommendations on how Nigeria can harness the opportunities latent in AGOA using statistical inference and in-depth interview with relevant stakeholders. The findings show that despite the privileged economic relations with the United States of America (USA), Nigeria is yet to optimise the benefits derivable from the AGOA initiative. Weak adherence to international products packaging and standards, weak manufacturing base, and inadequate infrastructural provision, among others, have limited Nigeria's possible gains from AGOA. Hence, this study submits that Nigeria can improve its export performance under AGOA, given the considerable untapped potentials in many AGOA-product sectors

Agro-industrialisation and financial intermediation in Nigeria

Purpose – The study aims to analyse the role of finance in the agro-industrialisation nexus in Nigeria using annual data on manufacturing value added, agricultural value added and volume of finance availed to the agricultural sector from 1981 to 2015. Design/methodology/approach – To establish the presence of a long-run relationship, the error correction model and bounds cointegration techniques are employed. Likewise, the model is augmented to test whether the associated relationship between industrial output and agricultural output depends on access to finance by farmers with the inclusion of an interaction term. Findings – Some salient contributions to the literature are as follows: agriculture and finance are strong and positive predictors of industrialisation in the long run; in the short run, past realisations of industrial output and finance have significant asymmetric effects on industrial output; the explanatory power of agriculture decreases with the growth of the financial system; and the long-run results validate the role of finance in the agro-industrialisation nexus. Originality/value – Given these findings, achieving growth in the agricultural sector that will induce desired industrialisation should be prioritised by the government through agencies such as the central bank, financial intermediaries and other stakeholders with a view to making agricultural financing a major concern for sustainable domestic consumption and industrial growth

The Role of Institutions in the Finance-Inequality Nexus in Sub-Saharan Africa

This study contributes to the literature on income inequality by providing evidence that financial development not only impacts income distribution, but the effects can improve when there is a strong institutional framework. Using the system-generalised method of moments (sys-GMM) technique on a sample of 42 Sub-Saharan African (SSA) countries from 1996 to 2015, our major findings are summarised as follows: (1) inequality is persistent in the region (2) financial development does not significantly reduce income inequality; and (3) the control of corruption and its interaction with domestic credit exhibit an inverted-U relation with income inequality. Thus, policies that will reduce income inequality require that corruption be controlled given increase in domestic credit