3 research outputs found
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
- Author
- Aanensen David M.
- Abraham Priyanka
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Adele Sandra
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Ansari M. Azim
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Ashraf Shirin
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Austin James
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barnes Eleanor
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Bouzidi Kate El
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Anthony
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Cantoni Diego
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Churcher Carol M.
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J.
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R.
- Cook Kate F.
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cowton Vanessa
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R.
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- Cutino-Moguel Teresa
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert M.
- Davis Chris
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- De Lorenzo Giuditta
- de Oliveira Martins Leonardo
- de Silva Thushan
- de Silva Thushan I.
- Debebe Johnny
- Deeks Alexandra
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Dunachie Susanna
- Dunachie Susanna
- Duncan Christopher
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J.
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Everson William
- Fairley Derek J.
- Fallon Karlie
- Fanaie Arezou
- Farr Ben W.
- Fearn Christopher
- Feltwell Theresa
- Ferguson Lynne
- Fina Laia
- Flaviani Flavia
- Fleming Vicki M.
- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H.
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Fryer Helen
- Fuchs Marc
- Fuller William
- Furnon Wilhelm
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D.
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
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- Grove Joe
- Guest Martyn
- Gunson Rory
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- Gupta Ravi K.
- Gutierrez Bernardo
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- Hamilton William L.
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- Haque Tanzina
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- Hassan-Ibrahim Mohammed O.
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- Idle Giles
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
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- Jahun Aminu S.
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- Kronsteiner Barbara
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- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G.
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- Percival Benita
- Perkins Jon
- Perry Malorie
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- Pohare Manoj
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- Pope Cassie F.
- Poplawski Radoslaw
- Powell Jessica
- Poyner Jennifer
- Prestwood Liam
- Price Anna
- Price James R.
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- Pugh Georgia
- Pusok Monika
- Puxty Kathryn
- Pybus Oliver G.
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- Raghwani Jayna
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- Sambles Christine M.
- Sanderson Roy
- Sanderson Theo
- Sang Fei
- Sass Thea
- Scher Emily
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- Scott Garren
- Scott Sam
- Sehmi Jasveen
- Shaaban Sharif
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G.
- Sheridan Liz A.
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silva Vanessa
- Silviera Siona
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- Singh Aditi
- Singleton Dawn
- Skvortsov Timofey
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren L.
- Smith Ken
- Smith Kim S.
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- Smith Nikki
- Smith Perminder
- Smollett Katherine
- Smollett Katherine L.
- Snell Luke B.
- Somassa Thomas
- Southgate Joel
- Spellman Karla
- Spencer Chapman Michael H.
- Spurgin Lewis G.
- Spyer Moira J.
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- Stanley William
- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
- Swindells Emma
- Szemiel Agnieszka
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben E. W.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton Kate
- Templeton Kate E.
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- Thomson Emma C.
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tomb Rachael
- Tong Lily
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- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vink Elen
- Vipond Barry B.
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Wilkie Craig
- Willett Brian J.
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
- Witney Adam A.
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/08/2022
- Field of study
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant
IASIL Bibliography for 2011
- Author
- Adele TWOHIG
- Agudo Elices
- Aideen KERR
- Aisling MCKEOWN
- Alberto A LVAREZ LUGRI S
- Allan HEPBURN
- Angela BOURKE
- Anna TEEKELL
- Anthony ROCHE
- Ariel WATSON
- ARMSTRONG
- Ashley MARSHALL
- Ashley MARSHALL
- Austin RIEDE
- Barbara PUSCHMANN-NALENZ
- Barry SLOAN
- Barry SLOAN
- Benjamin KEATINGE
- BENNETT
- Bernadette MCCARTHY
- Bernard HASLAM
- BERT
- BIERMAN
- BLOOM
- Brad KENT
- Brad KENT
- Brian TRENCH
- Bronwen WALTER
- BROWN
- Bryan RADLEY
- CARDULLO
- CARDULLO
- Carmelo MEDINA CASADO
- CARROLL
- CARROLL
- CASEY
- Charles BARR
- Charlotte MC IVOR
- Christina MORIN
- Christopher FITZ-SIMON
- CHUDGAR
- CLARKE
- Claude MAISONNAT
- Conn HOLOHAN
- COPE
- COUNTER
- CREEDON
- Cristina GA MEZ-FERNA NDEZ
- CROSSON
- Csilla BERTHA
- Damien MURRAY
- Daniel KATZ
- Daniel MORAN
- DE BRU N
- Deirdre MASK
- Derek GLADWIN
- Donal O MATHUNA
- DONOHUE
- DUDY
- DUKORE
- DUKORE
- EBURNE
- Eckart GOEBEL
- Edward DUTTON
- Edward SHEA
- Eglantina REMPORT
- EIDE
- Elisabeth DELATTRE
- Elisabeth DELATTRE
- Elizabeth DELATTRE
- Emilie MORIN
- Emilie MORIN
- Emmie MCFADDEN
- Eoghan SMITH
- ERASMO
- Erin ROSHAL
- ESTE VEZ-SA A
- Eunice ROJAS
- Faith BINCKES
- Ferenc TAKA CS
- Ferenc TAKA CS
- Ferenc TAKA CS
- Fernando ALONSO ROMERO
- Fiachra BROLCHA IN
- FIGLEROWICZ
- FLANNERY
- FLYNN
- FLYNN
- FLYNN
- Fran BREARTON
- Fran ROURKE
- Francisco CALVO DEL OLMO
- Francisco GARCI A TORTOSA
- Franck MIROUX
- Frank CALLANAN
- FREITAS BOE
- Fritz SENN
- Fritz SENN
- Fritz SENN
- Fritz SENN
- GAEDTKE
- Gail MCCONNELL
- Gerardine MEANEY
- Gerd BAYER
- GILLESPIE
- GIRARD
- Gisele WOLKOFF
- GONTARSKI
- GONTARSKI
- Graham PRICE
- Gregory LYNALL
- Gregory MACKIE
- Guillermo SANZ GALLEGO
- HAYS
- Heidi HANSSON
- Helen BURKE
- Henry PATTERSON
- HIBBERT
- Hilary TOVEY
- HOPPER K., MURPHY
- Iain TWIDDY
- Isidor SASLAV
- Ivan WISE
- JACKSON
- James LAVERTY
- James MC ELROY
- Jason BUCHANAN
- JASPE A
- Jean MERCEREAU
- Jeanette ROBERTS SHUMAKER
- Jeff PORTER
- Jefferson HOLDRIDGE
- Jeffrey BILBRO
- Jim LEBLANC
- Joanna KRUCZKOWSKA
- John BARRY
- John GIBNEY
- John HILL
- Jon ERICKSON
- Jorge BASTOS DA SILVA
- Jose CARREGAL-ROMERO
- Jose Francisco FERNA NDEZ SA NCHEZ
- Joseph NUGENT
- JYLKKA
- Karen BABINE
- Karen Marguerite MOLONEY
- Katarzyna OJRZYN SKA
- Katharina WALTER
- KAY
- Keith HOPPER
- Keith HOPPER
- Kelly MATTHEWS
- Kieran FLANAGAN
- KIRWAN
- KRESS
- KURDI
- Lance PETTIT
- LARKIN
- Laura CONNOR
- Laura LOJO RODRI GUEZ
- Laura LOJO RODRI GUEZ
- LEAVY
- Leeann LANE
- LEMOS
- LEVY
- Lidan LIN
- Lisa FITZPATRICK
- Lisa FITZPATRICK
- Lisa FLUET
- LORENZO-MODIA
- LORENZO-MODIA
- LYNCH
- Maciej RUCZAJ
- MANNION
- Manuela PALACIOS GONZA LEZ
- MARANTE ARIAS
- Marcus FREE
- Marcus FREE
- Margarita ESTE VEZ-SA A
- Margarita ESTE VEZ-SA A
- Margarita ESTE VEZ-SA A
- Maria DOYLE
- Marie GLEESON O TUATHAIGH
- Marjorie HOWES
- Marjorie HOWES
- Mark CONNELL
- Martin MCLOONE
- Matthew MCATEER
- Matthew SCHULTZ
- Maurice HARMON
- Maurice HARMON
- Melanie MCMAHON
- MEYER
- Michael BOGUCKI
- Michael Patrick GILLESPIE
- Michal LACHMAN
- Michel DUFOUR
- Monica INSINGA
- MOORE
- MORAN
- MORAN
- MORIKAWA
- MORSE
- Moya CANNON
- Moynagh SULLIVAN
- MOYNIHAN
- Muireann LEECH
- Muireann LEECH
- NI BEACHAIN
- Noemi PEREIRA ARES
- Norbert COL
- NORDIC IRISH STUDIES
- O LAOIRE L.
- Orla FITZPATRICK
- Padraic KILLEEN
- Padraic KILLEEN
- Padraig MURPHY
- Patrick MALEY
- Paul CARPENTER
- Paul GOETSCH
- Paul KINTZELE
- PEARSON
- Peter LENZ
- Petra KIRCHHOFF
- PFEIFFER
- Phillip RILEY
- PIERCE
- Pilar VILLAR-ARGA IZ
- PINTE R
- POWELL
- PRAGA TERENTE
- Qi CHEN
- RAWASHDEH
- REAL
- REICHMANN
- REILLY
- Ri GUEZ
- RI O MOLINA
- Ricardo NAVARRETE FRANCO
- Richard BEGAM
- Richard CONYNGHAM
- Richard Rankin RUSSELL
- Riona NIC CONGAIL
- Rob DOGGET
- Robert COHEN
- ROGERS
- Roland MCHUGH
- Rolf BREUER
- Roy BENJAMIN
- Ruben MOI
- SAN JOSE RICO P.
- Sandrine BRISSET
- Sarah MARSH
- Scarlet BARON
- SCHULKINS
- Sex And Aesthetics In STEWART P.
- Shane ALCOBIA-MURPHY
- Shane MCCORRISTINE
- Shannon FORBES
- Sharon ALKER
- Sophie READ
- SPURR
- STAFFORD
- STOBER
- Svetlana BUCHMAN
- SWITZKY
- Sylvie MIKOWSKI
- TABAN
- TAGUE
- TALHARI
- TCHAPRAZOV
- TEEKELL
- Teresa LOURO
- Tom INGLIS
- Tom WALKER
- TOWNSEND
- TUNNEY
- ULLYOT
- Val NOLAN
- Val NOLAN
- Vera KREILKAMP
- Vera REGAN
- Vivien IGOE
- WACHTEL
- Walter BRONWEN
- Weertje WILLMS
- WEHLAU
- WEINTRAUB
- WILLIAMS
- WILLIAMS
- Wojciech KLEPUSZEWSKI
- Yulia Pushkarevskya NAUGHTON
- Publication venue
- 'Edinburgh University Press'
- Publication date
- Field of study
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway (Nature Microbiology, (2022), 7, 8, (1161-1179), 10.1038/s41564-022-01143-7)
- Author
- Aanensen DM
- Abraham P
- Abudahab K
- Adams A
- Adams H
- Adele S
- Afifi S
- Aggarwal D
- Ahmad SSY
- Aigrain L
- Alcolea-Medina A
- Alikhan N-F
- Allara E
- Amato R
- Angyal A
- Annett T
- Ansari MA
- Aplin S
- Ariani CV
- Asad H
- Asamaphan P
- Ash A
- Ashfield P
- Ashford F
- Ashraf S
- Atkinson L
- Attwood SW
- Auckland C
- Austin J
- Aydin A
- Baker DJ
- Baker P
- Balcazar CE
- Ball J
- Barnes E
- Barrett JC
- Barrow M
- Barton E
- Bashton M
- Bassett AR
- Batra R
- Baxter C
- Bayzid N
- Beaver C
- Beckett AH
- Beckwith SM
- Bedford L
- Beer R
- Beggs A
- Bellis KL
- Berry L
- Bertolusso B
- Best A
- Betteridge E
- Bibby D
- Bicknell K
- Binns D
- Birchley A
- Bird PW
- Bishop C
- Blacow R
- Blakey V
- Blane B
- Bolt F
- Bonfield J
- Bonner S
- Bonsall D
- Boswell T
- Bosworth A
- Bourgeois Y
- Bouzidi KE
- Boyd O
- Bradley DT
- Breen C
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