The roles of pharmacists in responding to public health emergencies: a case of COVID-19

Emergencies are a significant menace to health services. The coronavirus disease 2019 (COVID-19) is one such emergency that took the world unaware and demanded more concentration from health-care providers, including pharmacists. To keep the pandemic at bay, pharmacists had to work on the frontline and to large extent, they still work alongside other healthcare professionals leveraging on the lessons learnt from the pandemic. The intent of this study was to present a general survey of pharmacists’ role in responding to public health emergencies, some challenges faced and some strategies that have been formulated by which they can perform these roles correctly. The study was carried out by searching databases such as the World Health Organization, Yale Medicine, NCBI, CDC, Google Scholar, Research gate, WebMD, and PubMed. It was discovered that pharmacists are now greatly involved in COVID-19 vaccine administration, COVID-19 testing, and sensitization

Creating a web-based electronic tool to aid tuberculosis (TB) cluster investigation: data integration in TB surveillance activities in the United Kingdom, 2013 to 2016.

Molecular technology to identify relatedness between Mycobacterium tuberculosis complex isolates, representative of possible tuberculosis (TB) transmission between individuals, continues to evolve. At the same time, tools to utilise this information for public health action to improve TB control should also be implemented. Public Health England developed the Strain Typing Module (STM) as an integral part of the web-based surveillance system used in the United Kingdom following the roll-out of prospective 24 loci mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) strain typing. The creation of such a system required data integration and linkage, bringing together laboratory results and patient notification information. The STM facilitated widespread access to patient strain typing and clustering results for the public health community working in TB control. In addition, the system provided a log of cluster review and investigation decision making and results. Automated real-time data linkage between laboratory and notification data are essential to allow routine use of genotyping results in TB surveillance and control. Outputs must be accessible by those working in TB control at a local level to have any impact in ongoing public health activity

Effect of Oral Placement and Expressive Therapies on Speech Intelligibility of Adolescents with Articulation Disorder

Intelligible speech is vital to every adolescent's life, but this skill can be confounded with the presence of articulation disorder. Meanwhile, studies have been conducted using different therapies to improve speech intelligibility. This study investigated the effect of oral placement and expressive therapies on speech intelligibility among adolescents with articulation disorders. The study adopted a pretest-posttest, control group, quasi-experimental research design with a 3x2x2 factorial matrix. Three special centers were randomly selected, and purposive sampling was used in selecting 60 adolescents having articulation disorders comprising 34 males and 26 females. These adolescents were randomly assigned to Experimental Group 1 (n= 22), Experimental Group 2 (n= 21), and Control (n= 17). Speech Intelligibility Assessment Scale (r=0.92) was the instrument used for the study. Participants in the experimental groups were exposed to the oral placement and expressive therapeutic treatments, while those in the control groups were sensitized to a placebo. Three hypotheses were tested at a 0.05 level of significance, while data were analyzed using Analysis of Covariance (ANCOVA), mean scores, and Bonferroni Post Hoc Test. Findings revealed that there was a significant main effect of treatments F(2,56) = 112.52; p <0.05 (oral placement therapy, expressive therapy, and control group with placebo), and also a significant interaction effect of treatments, gender, and age F(2, 47) = 7.37; p <0.05 on speech intelligibility of adolescents with articulation disorders despite the presence of placebo. Oral placement and expressive therapies were effective in managing the speech intelligibility of adolescents with articulation disorders. Therefore, speech therapists should adopt these therapeutic interventions in rehabilitating adolescents with articulation disorders

Adaptation of the Wound Healing Questionnaire universal-reporter outcome measure for use in global surgery trials (TALON-1 study): mixed-methods study and Rasch analysis

BackgroundThe Bluebelle Wound Healing Questionnaire (WHQ) is a universal-reporter outcome measure developed in the UK for remote detection of surgical-site infection after abdominal surgery. This study aimed to explore cross-cultural equivalence, acceptability, and content validity of the WHQ for use across low- and middle-income countries, and to make recommendations for its adaptation.MethodsThis was a mixed-methods study within a trial (SWAT) embedded in an international randomized trial, conducted according to best practice guidelines, and co-produced with community and patient partners (TALON-1). Structured interviews and focus groups were used to gather data regarding cross-cultural, cross-contextual equivalence of the individual items and scale, and conduct a translatability assessment. Translation was completed into five languages in accordance with Mapi recommendations. Next, data from a prospective cohort (SWAT) were interpreted using Rasch analysis to explore scaling and measurement properties of the WHQ. Finally, qualitative and quantitative data were triangulated using a modified, exploratory, instrumental design model.ResultsIn the qualitative phase, 10 structured interviews and six focus groups took place with a total of 47 investigators across six countries. Themes related to comprehension, response mapping, retrieval, and judgement were identified with rich cross-cultural insights. In the quantitative phase, an exploratory Rasch model was fitted to data from 537 patients (369 excluding extremes). Owing to the number of extreme (floor) values, the overall level of power was low. The single WHQ scale satisfied tests of unidimensionality, indicating validity of the ordinal total WHQ score. There was significant overall model misfit of five items (5, 9, 14, 15, 16) and local dependency in 11 item pairs. The person separation index was estimated as 0.48 suggesting weak discrimination between classes, whereas Cronbach's α was high at 0.86. Triangulation of qualitative data with the Rasch analysis supported recommendations for cross-cultural adaptation of the WHQ items 1 (redness), 3 (clear fluid), 7 (deep wound opening), 10 (pain), 11 (fever), 15 (antibiotics), 16 (debridement), 18 (drainage), and 19 (reoperation). Changes to three item response categories (1, not at all; 2, a little; 3, a lot) were adopted for symptom items 1 to 10, and two categories (0, no; 1, yes) for item 11 (fever).ConclusionThis study made recommendations for cross-cultural adaptation of the WHQ for use in global surgical research and practice, using co-produced mixed-methods data from three continents. Translations are now available for implementation into remote wound assessment pathways