Terrorism and Assassination: Political Assassination as an Instrument of National Policy - An Inquiry into Operations, Expediency, Morality, and the Law

The 2002 Symposium opened on Thursday, April 11, with a role-playing exercise and town meeting: Assassination of a Terrorist Enemy. In this session, a group of nationally prominent political leaders, policy makers, scholars, and members of the intelligence, military, religious and civil liberties communities engaged in a role-playing exercise exploring a fictional scenario posing the question of whether the United States should undertake an operation to assassinate the leader of a terrorist organization deemed responsible for acts of violence against the United States. The issue was explored through historical, moral, religious, operational, political, diplomatic, and legal perspectives. The final segment of the program included a town meeting discussion in which members of the audience participated in the debate and deliberation. These issues were explored the next day of the conference in a series of more specifically focused sessions. The opening session, on Thursday, April 11 from 6:30-9:00 p.m., featured Jeff Addicott; June Aprille; William C. Banks; Azizah al-Hibri, professor of Law at the University of Richmond School of Law; Julie Laskaris, Professor of Classical Studies at the University of Richmond; Peter Raven-Hansen, Gary Solis, Porcher Taylor, and Robert Turner. Rodney A. Smolla, the Allen Professor of Law at the University of Richmond School of Law, served as moderator. The “Roundtable Session I: Policy, Politics, and Operations” session, held on Friday, April 12 from 9:00-10:15 a.m., was led by Jeff Addicott, William C. Banks, Peter Raven-Hansen, Gary Solis, and Robert Turner. John Paul Jones, Professor of Law at the University of Richmond School of Law, served as moderator. “Roundtable Session II: Moral and Religious Perspectives,” held on Friday, April 12 from 10:30-11:45 a.m., was led by Azizah al-Hibri, Professor of Law at the University of Richmond School of Law. Julie Laskaris, Professor of Classical Studies at the University of Richmond, served as moderator. “Roundtable Session III: Assassination as an Instrument of Policy and the Law,” held on Friday, April 12 from 1:30- 2:45 p.m., was led by Jeff Addicott, William C. Banks, Peter Raven-Hansen, Gary Solis, Professor John Paul Jones, and Robert Turner. Porcher Taylor served as moderator

Evaluating a complex system-wide intervention using the difference in differences method:The Delivering Choice Programme

We report the use of difference in differences (DiD) methodology to evaluate a complex, system-wide healthcare intervention. We use the worked example of evaluating the Marie Curie Delivering Choice Programme (DCP) for advanced illness in a large urban healthcare economy

484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults

OBJECTIVES/GOALS: Our study explores the dose-related effects of THC on cardiovascular measures, self-reported effects, balance, and cognitive function among older adults. We also evaluate the acceptability and feasibility of study procedures, to inform future study designs employing this population. METHODS/STUDY POPULATION: Using a within-subject, double-blind, placebo-controlled design and standard behavioral pharmacology methods, reasonably healthy male and female adults aged 55-70 years undergo an eligibility screening, followed by a mock session and 3 experimental sessions (>7 days apart). During experimental sessions, participants are administered cannabis-infused brownies with varying THC doses. Prior to and at multiple intervals post- consumption, subjects complete assessments including self reports and observer ratings, psychomotor and cognitive performance measures, and vital signs. Follow-up interviews regarding the experience will be conducted one day after each session. RESULTS/ANTICIPATED RESULTS: We anticipate our results to mirror those of previously reported studies conducted in adults under 45 years old in that a dose-response relationship exists for subjective drug effects and vital signs with the caveat that this relationship may be exacerbated in our population. We additionally anticipate findings that indicate THC impairs balance and coordination, potentially increasing the risk of falls and accidents among this population, and cognitive function, affecting attention, memory, and executive functions. Feedback provided during the follow-up interviews will help refine procedures for future studies, ensuring that the methodology is acceptable and feasible for this population. DISCUSSION/SIGNIFICANCE: Prior work demonstrates the safety and efficacy of THC in conditions common among older adults, however, no conclusive data regarding tolerability and safety in this population exists. The presented work is vital groundwork for future research on THC as a potential therapeutic for older adults