Hard limits on the postselectability of optical graph states

Coherent control of large entangled graph states enables a wide variety of quantum information processing tasks, including error-corrected quantum computation. The linear optical approach offers excellent control and coherence, but today most photon sources and entangling gates---required for the construction of large graph states---are probabilistic and rely on postselection. In this work, we provide proofs and heuristics to aid experimental design using postselection. We derive a fundamental limitation on the generation of photonic qubit states using postselected entangling gates: experiments which contain a cycle of postselected gates cannot be postselected. Further, we analyse experiments that use photons from postselected photon pair sources, and lower bound the number of classes of graph state entanglement that are accessible in the non-degenerate case---graph state entanglement classes that contain a tree are are always accessible. Numerical investigation up to 9-qubits shows that the proportion of graph states that are accessible using postselection diminishes rapidly. We provide tables showing which classes are accessible for a variety of up to nine qubit resource states and sources. We also use our methods to evaluate near-term multi-photon experiments, and provide our algorithms for doing so.Comment: Our manuscript comprises 4843 words, 6 figures, 1 table, 47 references, and a supplementary material of 1741 words, 2 figures, 1 table, and a Mathematica code listin

Advances in quantum machine learning

Here we discuss advances in the field of quantum machine learning. The following document offers a hybrid discussion; both reviewing the field as it is currently, and suggesting directions for further research. We include both algorithms and experimental implementations in the discussion. The field's outlook is generally positive, showing significant promise. However, we believe there are appreciable hurdles to overcome before one can claim that it is a primary application of quantum computation.Comment: 38 pages, 17 Figure

Mapping graph state orbits under local complementation

Graph states, and the entanglement they posses, are central to modern quantum computing and communications architectures. Local complementation---the graph operation that links all local-Clifford equivalent graph states---allows us to classify all stabiliser states by their entanglement. Here, we study the structure of the orbits generated by local complementation, mapping them up to 9 qubits and revealing a rich hidden structure. We provide programs to compute these orbits, along with our data for each of the 587 orbits up to 9 qubits and a means to visualise them. We find direct links between the connectivity of certain orbits with the entanglement properties of their component graph states. Furthermore, we observe the correlations between graph-theoretical orbit properties, such as diameter and colourability, with Schmidt measure and preparation complexity and suggest potential applications. It is well known that graph theory and quantum entanglement have strong interplay---our exploration deepens this relationship, providing new tools with which to probe the nature of entanglement

The visual and beyond : characterizing experiences with auditory, haptic and visual data representations

Research in sonification and physicalization have expanded data representation techniques to include senses beyond the visual. Yet, little is known of how people interpret and make sense of haptic and sonic compared to visual representations. We have conducted two phenomenologically oriented comparative studies (applying the Repertory Grid and the Microphenomenological interview technique) to gather in-depth accounts of people's interpretation and experience of different representational modalities that included auditory, haptic and visual variations . Our findings show a rich characterization of these different representational modalities: our visually oriented representations engage through their familiarity, accuracy and easy interpretation, while our representations that stimulated auditory and haptic interpretation were experienced as more ambiguous, yet stimulated an engaging interpretation of data that involved the whole body. We describe and discuss in detail participants' processes of making sense and generating meaning using the modalities' unique characteristics, individually and as a group. Our research informs future research in the area of multimodal data representations from both a design and methodological perspective.Postprin

STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects

<p>Abstract</p> <p>Background</p> <p>Asthma is characterised by increased numbers of Th2-like cells in the airways and IgE secretion. Generation of Th2 cells requires interleukin (IL)-4 and IL-13 acting through their specific receptors and activating the transcription factor, signal transducer and activator of transcription 6 (STAT6). STAT6 knockout mice fail to produce IgE, airway hyperresponsiveness and bronchoalveolar lavage eosinophilia after allergen sensitisation, suggesting a critical role for STAT6 in allergic responses.</p> <p>Methods</p> <p>We have investigated the expression of STAT6 in peripheral blood T-lymphocytes, alveolar macrophages and bronchial biopsies from 17 normal subjects and 18 mild-moderate steroid-naïve stable asthmatic patients.</p> <p>Results</p> <p>STAT6 expression was variable and was detected in T-lymphocytes, macrophages and bronchial epithelial cells from all subjects with no difference between normal and stable asthmatic subjects.</p> <p>Conclusions</p> <p>STAT6 expression in different cells suggests that it may be important in regulating the expression of not only Th2-like cytokines in T cells of man, but may also regulate STAT-inducible genes in alveolar macrophages and airway epithelial cells.</p

The Interleukin-6 inflammation pathway from cholesterol to aging – Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases

We describe the inflammation pathway from Cholesterol to Aging. Interleukin 6 mediated inflammation is implicated in age-related disorders including Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, Osteoporosis, Type 2 Diabetes, Dementia and Alzheimer's disease and some forms of Arthritis and Cancer. Statins and Bisphosphonates inhibit Interleukin 6 mediated inflammation indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion. Polyphenolic compounds found in plants, fruits and vegetables inhibit Interleukin 6 mediated inflammation by direct inhibition of the signal transduction pathway. Therapeutic targets for the control of all the above diseases should include inhibition of Interleukin-6 mediated inflammation

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Laboratory recreation of the Draupner wave and the role of breaking in crossing seas

Freak or rogue waves are so called because of their unexpectedly large size relative to the population of smaller waves in which they occur. The 25:6 m high Draupner wave, observed in a sea state with a significant wave height of 12 m, was one of the first confirmed field measurements of a freak wave. The physical mechanisms that give rise to freak waves such as the Draupner wave are still contentious. Through physical experiments carried out in a circular wave tank, we attempt to recreate the freak wave measured at the Draupner platform and gain an understanding of the directional conditions capable of supporting such a large and steep wave. Herein, we recreate the full scaled crest amplitude and profile of the Draupner wave, including bound set-up. We find that the onset and type of wave breaking play a significant role and differ significantly for crossing and non-crossing waves. Crucially, breaking becomes less crest-amplitude limiting for sufficiently large crossing angles and involves the formation of near-vertical jets. In our experiments, we were only able to reproduce the scaled crest and total wave height of the wave measured at the Draupner platform for conditions where two wave systems cross at a large angle