Hepatoprotective effects of ethanol extract of Caesalpiniabonduc against carbon tetrachloride induced hepatotoxicity in Albino Rats

The present study was carried out to evaluate the Acute toxicity, hepatoprotective and in-vivo antioxidant activities of ethanolic extract of Caesalpinia bonduc leaf on carbon tetrachloride (CCl4) induced liver damage using Swiss albino rats . The ethanolic extract of the plant of C. bonduc were suspended in 5 % tragacanth and then administered orally at doses of 250 and 500 mg/kg body weight for fourteen days before intraperitoneally injection of Carbon tetrachloride (CCl4) at dose of 2 mL/kg body weight. The plant extracts at 250 and 500mg/kg b.wt showed a remarkable hepatoprotective and invivo antioxidant activities against carbon tetrachloride CCl4 – induced hepatotoxity judged from the serum marker enzymes .The CCl4 induced significant increase in aspartate amino transferase( AST), alanine amino transferase (ALT), alkaline phophatase (ALP), total bilirubin, and malondyaldehyde (MDA) with a reduction of total protein, catalase, and glutathione peroxidase . Treatment of rats with different doses of plant extract (250 and 500 mg/kg b.wt.) significantly (P< 0.001) altered serum maker enzymes and antioxidant levels to near normal levels. The study suggests that C. Bonduc specifically chloroform and ethyl acetate fraction may be good sources of natural antioxidant and hepatoprotective substance.Keywords: Ceasalpiniabonduc, hepatoprotective, intraperitoneally , antioxidan

Effects of Combined Ethanol Extract of Anthocleista Vogelii and Alstonia Boonei Stem Barks on Liver Function Indices in Benign Prostatic Hyperplasia Induced

Objective: This study evaluated the effects of combined ethanol extract of Anthocleista vogelii and Alstonia boonei (CEAA) stem barks on the liver function indices of benign prostatic hyperplasia (BPH)-induced rats.Materials and Methods: Thirty (30) male Wistar rats were randomly grouped into five groups (n = 6). BPH was induced subcutaneously with 5 mg/kg/day of testosterone propionate in olive oil. Groups 1-3 served as normal, BPH control (untreated) and standard drug control respectively, while Groups 4 and 5 were BPH-induced rats and treated with 200 and 400 mg/kg/day of the CEAA respectively after one hour of the BPH induction. After twenty-eight days of treatments, biochemical and histopathological analyses were conducted using standard analytical procedures.Results: The acute toxicity result of CEAA indicated no mortality or adverse reactions. Significant body weight change was only observed in the first week from the group-administered 200 mg/kg/day of CEAA. Liver damage was evident in the BPH control characterized by significant (P<0.05) increase in relative liver weight and liver enzymes’ (AST, ALT, ALP) activities but a reduction in total protein and globulin levels. Treatment with CEAA attenuated the liver damage by significantly (P<0.05) reducing the elevated relative liver weight and liver enzyme function activities and elevated total protein and globulin levels.Conclusion: The revealed that the combined ethanol extract of Anthocleista vogelii and Alstonia boonei (CEAA) stem barks possess hepatoprotective effects that could improve liver integrity and functions in BPH induced rats. Keywords: Benign prostatic hyperplasia, liver marker indices, Anthocleista vogelii, Alstonia boonei, liver histomorpholog

Effects of combined ethanol extract of Funtumia africana and Abutilon mauritianum leaves (FAAM) on liver function indices of benign prostatic hyperplasia (BPH) induced rats

Objective: This study evaluated the effects of combined ethanol extract of Funtumia africana and Abutilon mauritianum leaves (FAAM) on the liver function indices of benign prostatic hyperplasia (BPH) induced rats. Materials and Methods: The study used 30 rats divided into 5 groups, comprising normal control, BPH control, standard control, and BPH induced rats treated with 200 and 600 mg/kg/day of FAAM respectively. Results: The BPH induction caused significant (p0.05) reduced AST, and alanine transaminase (ALT) activities relative to the BPH control. The BPH-induced rats treated with 600 mg/kg/day of FAAM had significantly (p<0.05) reduced ALP activities relative to the BPH control. Treatment with FAAM caused significant (p<0.05) increases in the total protein, albumin, globulin concentrations and significant (p<0.05) reductions in the total bilirubin and direct bilirubin concentrations relative to the BPH control. BPH had no observable adverse effects on the liver histomorphology of the rats. Conclusion: The findings of this study indicated that BPH impairs liver functions and treatment of BPH with combined ethanol extract of F. africana and A. mauritianum leaves restore normal liver functions in rats with BPH