Batten augmented triangular beam

The BAT (Batten-Augmented Triangular) BEAM is characterized by battens which are buckled in the deployed state, thus preloading the truss. The preload distribution is determined, and the effects of various external loading conditions are investigated. The conceptual design of a deployer is described and loads are predicted. The influence of joint imperfections on effective member stiffness is investigated. The beam is assessed structurally

Analysis of alternative marketing strategies for slaughter hog producers in Tennessee

Avoiding risk associated with adverse cash price movements and improving overall profit level are assumed objectives for the market hog producer. This research evaluated various marketing strategies for finish and farrow-to-finish hog operations to determine their impact on price risk and profit levels. These strategies were simulated with the use of models to represent the Tennessee finish and farrow-to-finish hog producer\u27s operations during the 1972-79 period. The strategies simulated included variations on cash contracting, futures market hedging, and the typical cash sale. Simulations were also used to evaluate the effectiveness of using production criteria in conjunction with selected marketing strategies as a method of avoiding production during unprofitable periods. The mean and variance of profitability were used as criteria for comparing the effectiveness of the strategies simulated. The primary results of the simulations showed that selective hedg-i/ ing and selective cash contracting strategies could give larger mean and lower variance of profitability than the full-cash, full-hedge, or full-contract strategies. This would indicate that a producer using the full-cash strategy could increase profits and reduce price risk by switching to one of the more selective hedging or cash contracting strategies, assuming similar production and market conditions to those of the simulation period. Analysis for hogs marketed before 1976 and after 1975 separately, showed no substantial changes in the ranking of the marketing strategies between the two periods. The use of cash and futures market price signals as criteria for production did not have a positive impact on mean profit for the hog finishing operation

DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML

<b>Background</b>. Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are neoplastic disorders of hematopoietic stem cells. DNA methyltransferase inhibitors (DNMTi), 5-azacytidine (AzaC) and 5-aza-2’-deoxycytidine (Decitabine), benefit some MDS/AML patients. However, the role of DNMTi-induced DNA hypomethylation in regulation of gene expression in AML is unclear.<p></p> <b>Results. </b> We compared the effects of AzaC on DNA methylation and gene expression using whole-genome single-nucleotide bisulfite-sequencing (WGBS) and RNA-sequencing in OCI-AML3 (AML3) cells. For data analysis, we used an approach recently developed for discovery of differential patterns of DNA methylation associated with changes in gene expression, that is tailored to single-nucleotide bisulfite-sequencing data (Washington University Interpolated Methylation Signatures (WIMSi)). By this approach, a subset of genes upregulated by AzaC was found to be characterized by AzaC-induced signature methylation loss flanking the transcription start site. These genes are enriched for genes increased in methylation and decreased in expression in AML3 cells compared to normal hematopoietic stem and progenitor cells. Moreover, these genes are preferentially upregulated by Decitabine in human primary AML blasts, and control cell proliferation, death and development. <p></p> <b>Conclusions.</b> Our WGBS and WIMSi data analysis approach has identified a set of genes whose is methylation and silencing in AML is reversed by DNMTi. These genes are good candidates for direct regulation by DNMTi, and their reactivation by DNMTi may contribute to therapeutic activity. This study also demonstrates the ability of WIMSi to reveal relationships between DNA methylation and gene expression, based on single-nucleotide bisulfite-sequencing and RNA-seq data.<p></p&gt

Existence and equilibration of global weak solutions to Hookean-type bead-spring chain models for dilute polymers

We show the existence of global-in-time weak solutions to a general class of coupled Hookean-type bead-spring chain models that arise from the kinetic theory of dilute solutions of polymeric liquids with noninteracting polymer chains. The class of models involves the unsteady incompressible Navier-Stokes equations in a bounded domain in two or three space dimensions for the velocity and the pressure of the fluid, with an elastic extra-stress tensor appearing on the right-hand side in the momentum equation. The extra-stress tensor stems from the random movement of the polymer chains and is defined by the Kramers expression through the associated probability density function that satisfies a Fokker-Planck-type parabolic equation, a crucial feature of which is the presence of a center-of-mass diffusion term. We require no structural assumptions on the drag term in the Fokker-Planck equation; in particular, the drag term need not be corotational. With a square-integrable and divergence-free initial velocity datum for the Navier-Stokes equation and a nonnegative initial probability density function for the Fokker-Planck equation, which has finite relative entropy with respect to the Maxwellian of the model, we prove the existence of a global-in-time weak solution to the coupled Navier-Stokes-Fokker-Planck system. It is also shown that in the absence of a body force, the weak solution decays exponentially in time to the equilibrium solution, at a rate that is independent of the choice of the initial datum and of the centre-of-mass diffusion coefficient.Comment: 86 page

QSO 0130-4021: A third QSO showing a low Deuterium to Hydrogen Abundance Ratio

We have discovered a third quasar absorption system which is consistent with a low deuterium to hydrogen abundance ratio, D/H = 3.4 times 10^-5. The z ~ 2.8 partial Lyman limit system towards QSO 0130-4021 provides the strongest evidence to date against large D/H ratios because the H I absorption, which consists of a single high column density component with unsaturated high order Lyman series lines, is readily modeled -- a task which is more complex in other D/H systems. We have obtained twenty-two hours of spectra from the HIRES spectrograph on the W.M. Keck telescope, which allow a detailed description of the Hydrogen. We see excess absorption on the blue wing of the H I Lyman alpha line, near the expected position of Deuterium. However, we find that Deuterium cannot explain all of the excess absorption, and hence there must be contamination by additional absorption, probably H I. This extra H I can account for most or all of the absorption at the D position, and hence D/H = 0 is allowed. We find an upper limit of D/H < 6.7 times 10^-5 in this system, consistent with the value of D/H ~ 3.4 times 10^-5 deduced towards QSO 1009+2956 and QSO 1937-1009 by Burles and Tytler (1998a, 1998b). This absorption system shows only weak metal line absorption, and we estimate [Si/H] < -2.6 -- indicating that the D/H ratio of the system is likely primordial. All four of the known high redshift absorption line systems simple enough to provide useful limits on D are consistent with D/H = 3.4 +/- 0.25 times 10^-5. Conversely, this QSO provides the third case which is inconsistent with much larger values.Comment: 18 pages, 5 figures, submitted to Ap

Substantial Red Wolf Genetic Ancestry Persists in Wild Canids of Southwestern Louisiana

Concerns over red wolf (Canis rufus) extinction caused by hybridization with coyotes (C. latrans) led to the capture and removal of remnant wild wolves from southwestern Louisiana and southeastern Texas, United States, during the 1970s. Here we show that despite decades of unmitigated hybridization, and declaration of endangered red wolves as functionally extinct in the wild, red wolf mitochondrial or nuclear DNA ancestry persists in ∼55% of contemporary wild canids sampled in southwestern Louisiana. Surprisingly, one individual had 78–100% red wolf ancestry, which is within the range for 75% red wolf, red wolf backcross, or putative red wolf, depending on estimation method. Our findings bolster support for designation of red wolves as a distinct species, demonstrate a critical need for the United States Government to consider adopting an existing but unimplemented hybrid policy, and suggest that immediate reassessment of canid management and taxonomic designation in southwestern Louisiana may be warranted