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Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138269/1/hep29286.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138269/2/hep29286_am.pd

Integrated Spacecraft Autonomous Attitude Control (ISAAC)

The purpose of this project is to give undergraduate students an opportunity to design, manufacture, and maintain a mock spacecraft to be used as a testbed for autonomous control systems. The spacecraft is based on two previous models: the JX-01, an undergraduate built testbed, and the Asteroid Free Flyer led by NASA engineer and ERAU doctoral student, Michael Dupuis. This model includes cable improvements, Inertial Measurement Units (IMU), Light Detection and Ranging (LIDAR), and object-based state estimation to improve control stabilization. When completed, the hardware built for this project will provide undergraduates and researchers a platform with which they can test control algorithms and spacecraft component design. The results gathered from the project thus far is the building and design and controls experience between the team. After completion we will be able to obtain a properly modeled control algorithm and test it against multiple conditions. The final goal of the spacecraft is to provide the capabilities and perform experiments to test multiple methods to mitigate the effects of internal and external forces such as fuel sloshing, solar radiation, debris collision, and CG change

Integrated Spacecraft Autonomous Attitude Control (ISAAC)

The purpose of this project is to give undergraduate students an opportunity to design, manufacture, and maintain a mock spacecraft to be used as a testbed for autonomous control systems. The spacecraft is based on two previous models: the JX-01, an undergraduate built testbed, and the Asteroid Free Flyer led by NASA engineer and ERAU doctoral student, Michael Dupuis. This model includes cable improvements, Inertial Measurement Units (IMU), Light Detection and Ranging (LIDAR), and object-based state estimation to improve control stabilization. When completed, the hardware built for this project will provide undergraduates and researchers a platform with which they can test control algorithms and spacecraft component design. The results gathered from the project thus far is the building and design and controls experience between the team. After completion we will be able to obtain a properly modeled control algorithm and test it against multiple conditions. The final goal of the spacecraft is to provide the capabilities and perform experiments to test multiple methods to mitigate the effects of internal and external forces such as fuel sloshing, solar radiation, debris collision, and CG change

An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration

SummaryDownregulation of the miR-143/145 microRNA (miRNA) cluster has been repeatedly reported in colon cancer and other epithelial tumors. In addition, overexpression of these miRNAs inhibits tumorigenesis, leading to broad consensus that they function as cell-autonomous epithelial tumor suppressors. We generated mice with deletion of miR-143/145 to investigate the functions of these miRNAs in intestinal physiology and disease in vivo. Although intestinal development proceeded normally in the absence of these miRNAs, epithelial regeneration after injury was dramatically impaired. Surprisingly, we found that miR-143/145 are expressed and function exclusively within the mesenchymal compartment of intestine. Defective epithelial regeneration in miR-143/145-deficient mice resulted from the dysfunction of smooth muscle and myofibroblasts and was associated with derepression of the miR-143 target Igfbp5, which impaired IGF signaling after epithelial injury. These results provide important insights into the regulation of epithelial wound healing and argue against a cell-autonomous tumor suppressor role for miR-143/145 in colon cancer

Uncovering Biological Factors That Regulate Hepatocellular Carcinoma Growth Using Patient‐Derived Xenograft Assays

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162740/3/hep31096.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162740/2/hep31096-sup-0001-Suppinfo.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162740/1/hep31096_am.pd

The Utility of Anatomical Liver Resection in Hepatocellular Carcinoma: Associated with Improved Outcomes or Lack of Supportive Evidence?

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Surgical resection of HCC remains one of the mainstays of curative therapies and is associated with five-year overall survival rates approaching 60%. Despite improved perioperative outcomes, locoregional recurrence within the first two years following hepatic resection is of significant concern with recurrence rates of up to 50%. The use of anatomical resection surgical approaches, whereby the portal venous blood flow is ligated proximal to the tumor bed, is postulated to reduce recurrence rates due to reduction of micrometastatic disease. The aim of this review is to characterize the definition of an anatomical resection (AR) during partial hepatectomy, discuss the theoretical advantages of AR during hepatic resection for HCC, and to present evidence of the impact of AR on outcome measures in patients with HCC. Based on current data, there is a lack of conclusive evidence to support the universal use of AR in cirrhotic patients with HCC. A randomized clinical trial is warranted to further clarify the debate between AR versus non-anatomical resection (NAR) for HCC

Anatomic vs. non-anatomic liver resection for hepatocellular carcinoma: standard of care or unfilled promises?

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death not only in the United States but in the world. One of the curative treatment options for early-stage HCC is surgical resection, which can be divided into two approaches: anatomic and nonanatomic. The theoretical advantage of anatomic liver resection is excising the entire primary tumor along with adjacent liver parenchyma containing micrometastases that reside in the surrounding portal tributaries. However, the superiority of anatomic vs. nonanatomic liver resection in patients with HCC is controversial. While this is a feasible strategy for patients with preserved liver function, it may not be ideal for patients with cirrhosis, who rely on parenchymal-sparing or nonanatomic approaches to maximize their future liver remnant and prevent post-operative liver failure. This review identifies and critically analyzes the evidence for anatomic vs. nonanatomic liver resection for HCC