Is it possible to make environmental science relevant to society at-large?

Over the last five U.S. presidential election cycles, public concern about environmental issues has seemingly declined while concerns about national security and economic issues have remained steady or increased. These changes in public attitudes have been associated with decreased attention to environmental issues amongst policymakers, a situation that contrasts strongly with the 1970s when public concern about environmental issues was high and environmental legislation was a U.S. federal government priority. “Framing” has been pro-posed as a tool that environmental scientists could use to increase the relevancy of their research to U.S. society at-large, thereby helping to change public attitudes and influence policymaking. However, if done haphazardly, some framing efforts can actually have the opposite effect. To combat this weakness, environmental scientists should join with experts in psychology, decision science, and social science to create interdisciplinary teams that can effectively communicate with the public, positively affect public opinion, and make environmental science more relevant and meaningful to society at-large

Slow Isotope Turnover Rates and Low Discrimination Values in the American Alligator: Implications for Interpretation of Ectotherm Stable Isotope Data

Stable isotope analysis has become a standard ecological tool for elucidating feeding relationships of organisms and determining food web structure and connectivity. There remain important questions concerning rates at which stable isotope values are incorporated into tissues (turnover rates) and the change in isotope value between a tissue and a food source (discrimination values). These gaps in our understanding necessitate experimental studies to adequately interpret field data. Tissue turnover rates and discrimination values vary among species and have been investigated in a broad array of taxa. However, little attention has been paid to ectothermic top predators in this regard. We quantified the turnover rates and discrimination values for three tissues (scutes, red blood cells, and plasma) in American alligators (Alligator mississippiensis). Plasma turned over faster than scutes or red blood cells, but turnover rates of all three tissues were very slow in comparison to those in endothermic species. Alligator δ15N discrimination values were surprisingly low in comparison to those of other top predators and varied between experimental and control alligators. The variability of δ15N discrimination values highlights the difficulties in using δ15N to assign absolute and possibly even relative trophic levels in field studies. Our results suggest that interpreting stable isotope data based on parameter estimates from other species can be problematic and that large ectothermic tetrapod tissues may be characterized by unique stable isotope dynamics relative to species occupying lower trophic levels and endothermic tetrapods

What do alligators eat on golf courses?

Urbanization is an ever-increasing threat to wildlife and their natural habitats, yet research has been limited to a small number of taxa and very few large predator species. The American alligator (Alligator mississippiensis) is an apex predator across the southeast U.S. and has surprisingly received minimal attention within urban areas. To investigate the potential effects of land development on alligator trophic ecology, we performed gut content analysis on golf course alligators found on Jekyll Island, Georgia. We then made comparisons with alligators found in more natural areas on Sapelo Island, Georgia. In total, we collected stomach content samples from 25 alligators on Jekyll Island golf courses, of which only one had an empty stomach. Data provided from Sapelo Island consisted of 93 alligators within our alligator size range, of which only one had an empty stomach. While analysis of similarity, non-metric multidimensional scaling, and simplified Morisita index analyses show no significant difference in diets between the two areas (possibly because of a low sample size from Jekyll Island), %IRI values for prey items reveal that there may be functional differences in prey choice or availability. Further land development and increasing human activity may therefore shift diets toward reliance on prey items usually of lesser importance. These trophic effects could possibly lead to local population declines, if paired with habitat degradation or other stressors

Bridging the Gap in the Technology Commercialization Process

Cogeneration merges the production of usable heat and electricity into a single process that helps to reduce carbon emissions, energy waste and energy costs. Until now, this source of sustainable energy has been used mostly in the industrial sector, the consumer market is unknown. One type of cogeneration system, the Stirling engine, is a heat engine that is operated by a cyclic compression and expansion of air or other gas at different temperatures. This cogeneration system is capable of charging a smartphone’s battery using the heat of everyday objects like a hot cup or a radiator, or a human hand. There are two main goals of this project; 1) is to design and build a small prototype using the Stirling engine technology to generate electricity; and 2) to conduct a market test to assess the appeal of the Stirling sustainable charger among consumers. Online surveys will be employed to conduct research to evaluate overall purchase interest in this new technology. The information to be collected will include demographic and attitudinal characteristics that can be used to help build consumer profiles, and identify which profiles correlate with higher levels of purchase interest for the Stirling sustainable charger. This research will be used to help position the Stirling charge, and to identify key target segments for the marketing of this product

The Roles of Large Top Predators in Coastal Ecosystems: New Insights from Long Term Ecological Research

During recent human history, human activities such as overhunting and habitat destruction have severely impacted many large top predator populations around the world. Studies from a variety of ecosystems show that loss or diminishment of top predator populations can have serious consequences for population and community dynamics and ecosystem stability. However, there are relatively few studies of the roles of large top predators in coastal ecosystems, so that we do not yet completely understand what could happen to coastal areas if large top predators are extirpated or significantly reduced in number. This lack of knowledge is surprising given that coastal areas around the globe are highly valued and densely populated by humans, and thus coastal large top predator populations frequently come into conflict with coastal human populations. This paper reviews what is known about the ecological roles of large top predators in coastal systems and presents a synthesis of recent work from three coastal eastern US Long Term Ecological Research (LTER) sites where long-term studies reveal what appear to be common themes relating to the roles of large top predators in coastal systems. We discuss three specific themes: (1) large top predators acting as mobile links between disparate habitats, (2) large top predators potentially affecting nutrient and biogeochemical dynamics through localized behaviors, and (3) individual specialization of large top predator behaviors. We also discuss how research within the LTER network has led to enhanced understanding of the ecological roles of coastal large top predators. Highlighting this work is intended to encourage further investigation of the roles of large top predators across diverse coastal aquatic habitats and to better inform researchers and ecosystem managers about the importance of large top predators for coastal ecosystem health and stability

MUC1-C drives myeloid leukaemogenesis and resistance to treatment by a survivin-mediated mechanism

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with an unmet need for improved therapies. Responses to standard cytotoxic therapy in AML are often transient because of the emergence of chemotherapy-resistant disease. The MUC1-C oncoprotein governs critical pathways of tumorigenesis, including self-renewal and survival, and is aberrantly expressed in AML blasts and leukaemia stem cells (LSCs). However, a role for MUC1-C in linking leukaemogenesis and resistance to treatment has not been described. In this study, we demonstrate that MUC1-C overexpression is associated with increased leukaemia initiating capacity in an NSG mouse model. In concert with those results, MUC1-C silencing in multiple AML cell lines significantly reduced the establishment of AML in vivo. In addition, targeting MUC1-C with silencing or pharmacologic inhibition with GO-203 led to a decrease in active β-catenin levels and, in-turn, down-regulation of survivin, a critical mediator of leukaemia cell survival. Targeting MUC1-C was also associated with increased sensitivity of AML cells to Cytarabine (Ara-C) treatment by a survivin-dependent mechanism. Notably, low MUC1 and survivin gene expression were associated with better clinical outcomes in patients with AML. These findings emphasize the importance of MUC1-C to myeloid leukaemogenesis and resistance to treatment by driving survivin expression. Our findings also highlight the potential translational relevance of combining GO-203 with Ara-C for the treatment of patients with AML

Modeling electrolytically top gated graphene

We investigate doping of a single-layer graphene in the presence of electrolytic top gating. The interfacial phenomena is modeled using a modified Poisson-Boltzmann equation for an aqueous solution of simple salt. We demonstrate both the sensitivity of graphene's doping levels to the salt concentration and the importance of quantum capacitance that arises due to the smallness of the Debye screening length in the electrolyte.Comment: 7 pages, including 4 figures, submitted to Nanoscale Research Letters for a special issue related to the NGC 2009 conference (http://asdn.net/ngc2009/index.shtml

Vimentin is a novel AKT1 target mediating motility and invasion.

The PI3K/AKT signaling pathway is aberrant in a wide variety of cancers. Downstream effectors of AKT are involved in survival, growth and metabolic-related pathways. In contrast, contradictory data relating to AKT effects on cell motility and invasion, crucial prometastatic processes, have been reported pointing to a potential cell type and isoform type-specific AKT-driven function. By implication, study of AKT signaling should optimally be conducted in an appropriate intracellular environment. Prognosis in soft-tissue sarcoma (STS), the aggressive malignancies of mesenchymal origin, is poor, reflecting our modest ability to control metastasis, an effort hampered by lack of insight into molecular mechanisms driving STS progression and dissemination. We examined the impact of the cancer progression-relevant AKT pathway on the mesenchymal tumor cell internal milieu. We demonstrate that AKT1 activation induces STS cell motility and invasiveness at least partially through a novel interaction with the intermediate filament vimentin (Vim). The binding of AKT (tail region) to Vim (head region) results in Vim Ser39 phosphorylation enhancing the ability of Vim to induce motility and invasion while protecting Vim from caspase-induced proteolysis. Moreover, vimentin phosphorylation was shown to enhance tumor and metastasis growth in vivo. Insights into this mesenchymal-related molecular mechanism may facilitate the development of critically lacking therapeutic options for these devastating malignancies