Influence of a lower content of energy in the ration on blood biochemical profile and selected hormones concentration in bulls

The purpose of the study was to examine the blood biochemical profile and selected hormones content in Black-and-White Polish Holstein-Fresian bulls (PHF) and crossbreds obtained from PHF dams sired by Limousine (PHFxLM), on different date during the experiment. Animals in group: I (PHF) and III (PHFxLM) over 63 days prior to slaughter were provided with the ration energy limited to 80% of the maintenance requirement. Until slaughter the bulls in group II (PHF) and IV (PHFxLM) were receiving a balanced ration. Blood from all the animals was collected three times. The date of blood collection during the experiment did not have a significant effect on the content of total protein, albumin, triglyceride and alanine aminotransferase activity (ALT) as well as the insulin and triiodothyronine (T3) content. Significant increase in the level of glucose in group II and IV, HDL and urea in III and activity of AST in all groups in 14th (B) and 70th (C) day of experiment occurred. Significant decrease of thyroxine (T4) was found in all animals. The analyses of total blood plasma cholesterol initially showed decrease and then significant increase

I/O Impedance Matching Algorithm for HighPerformance ASICs

Abstract This paper discusses a design style that utilizes an area array of flip-chip solder bump connections, I/O circuit designs that implement a programmable impedance matching algorithm, and a design system that must utilize these features during chip layout, chip checking, and release to manufacturing. Results from a recent test chip will also be given

Pharmacokinetic and Pharmacodynamic Profiling of Minocycline for Injection following a Single Infusion in Critically Ill Adults in a Phase IV Open-Label Multicenter Study (ACUMIN)

Intravenous (i.v.) minocycline is increasingly used to treat infections caused by multidrug-resistant (MDR) Acinetobacter baumannii. Despite its being approved nearly 50 years ago, published information on its pharmacokinetic (PK) profile is limited. This multicenter study examined the PK and probability of pharmacokinetic-pharmacodynamic (PK-PD) target attainment profile of i.v. minocycline in critically ill patients, with suspected or documented infection with Gram-negative bacteria. The PK study population included 55 patients who received a single 200-mg i.v. dose of minocycline. Plasma PK samples were collected predose and 1, 4, 12, 24, 36, and 48 h after initiation of minocycline. Total and unbound minocycline concentrations were determined at each time point. Probabilities of achieving the PK-PD targets associated with stasis and 1-log killing (free area under the curve above the MIC [fAUC:MIC] of 12 and 18, respectively) in an immunocompetent animal pneumonia infection model of A. baumannii were evaluated. A two-compartment population PK model with zero-order i.v. input and first-order elimination, which estimated a constant fraction unbound (f(ub)) for minocycline, best characterized the total and unbound plasma minocycline concentration-time data. The only two covariates retained in the final PK model were body surface area (associated with central volume of distribution) and albumin (associated with f(ub)). In the PK-PD probability of target attainment analyses, minocycline 200 mg i.v. every 12 h (Q12H) was predicted to result in a suboptimal PK-PD profile for patients with A. baumannii infections with MIC values of >1 mg/liter. Like all PK-PD profiling studies of this nature, these findings need clinical confirmation

International Criminal Justice

Prof. Adam Oler discusses international criminal justice. Speaker: Prof. Adam Oler, Col., USAF (Ret.), National Defense Universit

International Criminal Justice

Prof. Adam Oler discusses international criminal justice. Speaker: Prof. Adam Oler, Col., USAF (Ret.), National Defense Universit

The Looming Demise of the ICC\u27s Complementarity Principle: Israel, U.S. Interests, and the Court\u27s Future

The reported detention of a retired Israeli Defense Forces (IDF) officer by British authorities in late 2015 should reignite concerns among senior officials in Washington and elsewhere about the role of the International Criminal Court (ICC). The issue for U.S. and other policy makers is whether to denounce detention incidents like the one in Britain and insist that the ICC respect the foundational limits on its jurisdiction. At a minimum, the U.S. President should call on the ICC Chief Prosecutor to repudiate efforts to haul IDF veterans into the Court\u27s chambers, and terminate her preliminary enquiry into IDF conduct during the Gaza War. Doing so would not only be in the interests of the United States and its allies, but in the interest of the ICC as well

Ethics in an Era of Complexity and Security

Speaker: Prof. (Col.) Adam Oler, National Defense Universit

The Regimental History of the 36th Regiment of Virginia Infantry, CSA

(Statement of Responsibility) by Adam Oler(Thesis) Thesis (B.A.) -- New College of Florida, 1990(Electronic Access) RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE(Bibliography) Includes bibliographical references.(Source of Description) This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.(Local) Faculty Sponsor: Doenecke, Justu