Clarke's analysis of drugs and poisons.

"This book is adapted from contributions published in volume 1 of Clarke's analysis of drugs and poisons, 3rd edition."Includes bibliographical references and index.xxiv, 648 pages. :This textbook is based on Volume 1 of "Clarke's Analysis of Drugs and Poisons" by Moffatt, Osselton and Widdop (ISBN 9780853694731). The text is aimed at students undertaking Forensic Science degrees (B.Sc or M.Sc). Existing chapters from Clarke's have been edited for a student audience.Forensic science courses in the UK have been developed since 1990. To date, there are over 50 degree programmes (now also including M.Sc) and over 350 possible course combinations with a Forensic element to them. A brief survey of student intake for these courses over the past three years revealed an exponential rise in numbers which is set to continue. This situation is mirrored in the US, Europe and the rest of the world.Analytical Toxicology is an important subject within Forensic Science and this textbook has been developed based on Volume 1 of "Clarke's Analysis of Drugs and Poisons" (ISBN 9780853697114). The existing chapters from Clarke's have been edited for a student audience, rendering the material suitable for a recommended course textbook.The editors, Sue Jickells and Adam Negrusz are actively engaged in teaching analytical toxicology at respected universities (King's College, London and University of Illinois at Chicago). This title will be of interest to academics teaching Forensic Science, Analytical Chemistry, Biomedical Science and to students of Forensic Science (MSc and BSc)

Plasma Concentrations of Fentanyl Achieved With Transdermal Application in Chickens

Providing appropriate analgesia is an important concern in any species. Fentanyl, a μ-receptor specific opioid, use is common in mammalian species but has been incompletely evaluated for this purpose in avian species. Transdermal fentanyl patches were applied to domestic chickens (n = 10) of varying breeds for 72 hours. Repeated blood samples were collected from the birds to assess time-concentration of fentanyl and norfentanyl in plasma, as assayed by liquid chromatography-mass spectrometry, throughout patch application and for 48 hours after patch removal. Compartmental modeling was used to characterize the elimination profiles. Evaluation as a large bolus, followed by slower elimination rates over the remaining time, best fit the data as a one-compartment open model. Although maximum plasma fentanyl concentrations varied substantially by individual birds, chickens trended into 2 general groups of maximum plasma concentration, clearance, and volume of distribution, which was attributed to absorption variability. For all birds, harmonic mean of elimination half-life was 7.2 ± 3.7 hours and showed less individual variation than the other pharmacokinetic parameters. Because the application of transdermal fentanyl patches in the chickens achieved plasma fentanyl concentrations considered therapeutic in people, this approach could provide an additional analgesic option for avian patients

Chorzy trudni typowiSkuteczny zabieg przezskórnej angioplastyki tętnicy nerkowej u chorego z ciężkim nadciśnieniem tętniczym i objawami hiperaldosteronizmu

Arterial hypertension may result from renal artery stenosis. In this type of hypertension renin-angiotensin-aldosterone system is activated and patients often produce signs of hyperaldosteronism. It must be distinguished from primary hyperaldosteronism in order to chose a proper therapy. In this paper we describe a case of a 65-years-old man with severe arterial hypertension, which was difficult to control pharmacologically. The patient revealed symptoms which suggested primary hyperaldosteronism (except normal plasma renin activity). Only imaging techniques allowed diagnose of renal artery stenosis and carry out successful percutaneous angioplasty of renal artery