Nested general linear model, means, standard deviation (SD) for endocrine and catecholamine parameters for bottlenose dolphins from managed-care (Marine Mammal Program (MMP), Georgia Aquarium (GA) and wild populations (Indian River Lagoon (IRL), FL, Charleston (CHS), SC, adjusted for age and sex, by site.

<p>Nested general linear model, means, standard deviation (SD) for endocrine and catecholamine parameters for bottlenose dolphins from managed-care (Marine Mammal Program (MMP), Georgia Aquarium (GA) and wild populations (Indian River Lagoon (IRL), FL, Charleston (CHS), SC, adjusted for age and sex, by site.</p

Nested general linear model, means, standard deviation (SD) for protein electrophoresis for bottlenose dolphins from managed-care Georgia Aquarium (GA) and wild populations (Indian River Lagoon (IRL), FL, Charleston (CHS), SC, adjusted for age and sex, by site.

<p>Nested general linear model, means, standard deviation (SD) for protein electrophoresis for bottlenose dolphins from managed-care Georgia Aquarium (GA) and wild populations (Indian River Lagoon (IRL), FL, Charleston (CHS), SC, adjusted for age and sex, by site.</p

Nested general linear model, means, standard deviation (SD) for hematological parameters for bottlenose dolphins from managed-care (Marine Mammal Program (MMP) and Georgia Aquarium (GA)) and wild populations (Indian River Lagoon (IRL) and Charleston (CHS)), adjusted for age and sex, by site.

<p>Nested general linear model, means, standard deviation (SD) for hematological parameters for bottlenose dolphins from managed-care (Marine Mammal Program (MMP) and Georgia Aquarium (GA)) and wild populations (Indian River Lagoon (IRL) and Charleston (CHS)), adjusted for age and sex, by site.</p

Demographic data for bottlenose dolphins from managed-care (Marine Mammal Program (MMP), Georgia Aquarium (GA)) and wild populations (Indian River Lagoon (IRL), FL, Charleston (CHS), SC.).

<p>Demographic data for bottlenose dolphins from managed-care (Marine Mammal Program (MMP), Georgia Aquarium (GA)) and wild populations (Indian River Lagoon (IRL), FL, Charleston (CHS), SC.).</p

Gene transcript levels of measured cytokines from managed-care (Navy, Georgia Aquarium (GA)) and wild populations (Indian River Lagoon (IRL), FL, Charleston (CHS), SC), adjusted for age and sex, using a general linear model.

<p>Statistical differences between groups were found for the following five cytokines TNF, INFα, IL-4, IL-10, IRL2Rα (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0176202#pone.0176202.t005" target="_blank">Table 5</a> for statistical differences). Generally, higher transcript levels were found in wild dolphins versus one or both managed-care groups (note, the smaller the normalized value, the more a gene is transcribed, the larger the normalized value, the less a gene is transcribed).</p

Means and standard deviation of antibody titers to marine bacteria from managed-care (Navy, Georgia Aquarium (GA)) and wild populations (Indian River Lagoon (IRL), FL, Charleston (CHS), SC), adjusted for age and sex, using a general linear model.

<p>For all antibodies, significantly higher titers were found in wild dolphins compared to one or more of the managed dolphin groups (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0176202#pone.0176202.t005" target="_blank">Table 5</a> for statistical differences). No differences were observed between the two managed-care dolphin groups with their antibody titers to V. cholera and <i>M</i>. <i>marinarum</i> but differences occurred in the other three organisms (<i>E</i>. <i>rhusiopathiae</i>, <i>V</i>. <i>parahaemolyticus</i>, <i>E</i>.<i>coli</i>).</p