Registration errors: effect of an intervention.

<p>The test were performed with [¹¹C]PK11195 images. For the focal lesion test, Sprague-Dawley rats were divided in a healthy control group (<i>n</i> = 11) and intervention group (<i>n</i> = 10). For the herpes encephalitis (HSE) model, Wistar rats were divided in a healthy group (<i>n</i> = 19) and intervention group (<i>n</i> = 14). Parameter estimates were obtained using the healthy groups as reference category.</p><p>Registration errors: effect of an intervention.</p

Voxel-based analysis.

<p>Increased uptake of [¹¹C]PK11195 in the intervention group as compared to the healthy rats. For the focal lesion test, Sprague-Dawley rats were divided in a healthy control group (<i>n</i> = 11) and rats stereotaxic injected with saline (<i>n</i> = 10). For the herpes encephalitis model, Wistar rats were divided in a healthy group (<i>n</i> = 19) and infected rats (<i>n</i> = 14). For the interpretation of group differences, <i>T</i>-maps data were interrogated at <i>p</i> = 0.001 (uncorrected) and an extent threshold of 200 voxels. Only cluster with <i>p</i><0.05 family-wise error (FWE) corrected were considered significant.</p><p>Voxel-based analysis.</p

Distribution of the rats across experimental groups.

<p>Distribution of the rats across experimental groups.</p

Tracer-specific PET and SPECT templates.

<p>(A) Different horizontal brain sections, and (B) sagittal and coronal sections.</p

Flowchart.

<p>Construction of new tracer specific templates.</p

Mean SUV uptake, and right/left ratio obtained using VOI analysis.

<p>The SUV values for [¹⁸F]FDG and [^99mTc]HMPAO are corrected for the mean uptake value of the whole brain.</p><p>Mean SUV uptake, and right/left ratio obtained using VOI analysis.</p