4,013 research outputs found
Total and Monomethyl Mercury in Fog Water from the Central California Coast
[1] Total mercury (HgT) and monomethyl mercury (MMHg) concentrations in fog collected from 4 locations in and around Monterey Bay, California during June-August of 2011 were 10.7 ± 6.8 and 3.4 ± 3.8 ng L−1respectively. In contrast, mean HgT and MMHg concentrations in rain water from March-June, 2011 were 1.8 ± 0.9 and 0.1 ± 0.04 ng L−1 respectively. Using estimates of fog water deposition from 6 sites in the region using a standard fog water collector (SFC), depositions of HgT and MMHg via fog were found to range from 42–4600 and 14–1500 ng m−2 y−1, which accounted for 7–42% of HgT and 61–99% of MMHg in total atmospheric deposition (fog, rain, and dry deposition), estimated for the coastal area. These initial measurements suggest that fog precipitation may constitute an important but previously overlooked input of MMHg to coastal environments. Preliminary comparisons of these data with associated chemical, meteorological and oceanic data suggest that biotically formed MMHg from coastal upwelling may contribute to the MMHg in fog water
The Structure of IR Luminous Galaxies at 100 Microns
We have observed twenty two galaxies at 100 microns with the Kuiper Airborne
Observatory in order to determine the size of their FIR emitting regions. Most
of these galaxies are luminous far-infrared sources, with L_FIR > 10^11 L_sun.
This data constitutes the highest spatial resolution ever achieved on luminous
galaxies in the far infrared. Our data includes direct measurements of the
spatial structure of the sources, in which we look for departures from point
source profiles. Additionally, comparison of our small beam 100 micron fluxes
with the large beam IRAS fluxes shows how much flux falls beyond our detectors
but within the IRAS beam. Several sources with point- like cores show evidence
for such a net flux deficit. We clearly resolved six of these galaxies at 100
microns and have some evidence for extension in seven others. Those galaxies
which we have resolved can have little of their 100 micron flux directly
emitted by a point-like active galactic nucleus (AGN). Dust heated to ~40 K by
recent bursts of non-nuclear star formation provides the best explanation for
their extreme FIR luminosity. In a few cases, heating of an extended region by
a compact central source is also a plausible option. Assuming the FIR emission
we see is from dust, we also use the sizes we derive to find the dust
temperatures and optical depths at 100 microns which we translate into an
effective visual extinction through the galaxy. Our work shows that studies of
the far infrared structure of luminous infrared galaxies is clearly within the
capabilities of new generation far infrared instrumentation, such as SOFIA and
SIRTF.Comment: 8 tables, 23 figure
Revised Properties and Dynamical History for the HD 17156 System
From the thousands of known exoplanets, those that transit bright host stars
provide the greatest accessibility toward detailed system characterization. The
first known such planets were generally discovered using the radial velocity
technique, then later found to transit. HD 17156b is particularly notable among
these initial discoveries because it diverged from the typical hot Jupiter
population, occupying a 21.2 day eccentric () orbit, offering
preliminary insights into the evolution of planets in extreme orbits. Here we
present new data for this system, including ground and space-based photometry,
radial velocities, and speckle imaging, that further constrain the system
properties and stellar/planetary multiplicity. These data include photometry
from the Transiting Exoplanet Survey Satellite (TESS) that cover five transits
of the known planet. We show that the system does not harbor any additional
giant planets interior to 10 AU. The lack of stellar companions and the age of
the system indicate that the eccentricity of the known planet may have resulted
from a previous planet-planet scattering event. We provide the results from
dynamical simulations that suggest possible properties of an additional planet
that culminated in ejection from the system, leaving a legacy of the observed
high eccentricity for HD 17156b.Comment: 15 pages, 7 figures, accepted for publication in the Astronomical
Journa
Engaging with community researchers for exposure science: lessons learned from a pesticide biomonitoring study
A major challenge in biomonitoring studies with members of the general public is ensuring their continued involvement throughout the necessary length of the research. The paper presents evidence on the use of community researchers, recruited from local study areas, as a mechanism for ensuring effective recruitment and retention of farmer and resident participants for a pesticides biomonitoring study. The evidence presented suggests that community researchers' abilities to build and sustain trusting relationships with participants enhanced the rigour of the study as a result of their on-the-ground responsiveness and flexibility resulting in data collection beyond targets expected
Characterization of the mode of action of a potent dengue virus capsid inhibitor
Dengue viruses (DV) represent a significant global health burden, with up to 400 million infections every year and around 500,000 infected individuals developing life-threatening disease. In spite of attempts to develop vaccine candidates and antiviral drugs, there is a lack of approved therapeutics for the treatment of DV infection. We have previously reported the identification of ST-148, a small-molecule inhibitor exhibiting broad and potent antiviral activity against DV in vitro and in vivo (C. M. Byrd et al., Antimicrob. Agents Chemother. 57:15–25, 2013, doi:10 .1128/AAC.01429-12). In the present study, we investigated the mode of action of this promising compound by using a combination of biochemical, virological, and imaging-based techniques. We confirmed that ST-148 targets the capsid protein and obtained evidence of bimodal antiviral activity affecting both assembly/release and entry of infectious DV particles. Importantly, by using a robust bioluminescence resonance energy transfer-based assay, we observed an ST-148-dependent increase of capsid self-interaction. These results were corroborated by molecular modeling studies that also revealed a plausible model for compound binding to capsid protein and inhibition by a distinct resistance mutation. These results suggest that ST-148-enhanced capsid protein self-interaction perturbs assembly and disassembly of DV nucleocapsids, probably by inducing structural rigidity. Thus, as previously reported for other enveloped viruses, stabilization of capsid protein structure is an attractive therapeutic concept that also is applicable to flaviviruses
Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.
White adipose tissue (WAT) mass is determined by adipocyte size and number. While adipocytes are continuously turned over, the mechanisms controlling fat cell number in WAT upon weight changes are unclear. Herein, prospective studies of human subcutaneous WAT demonstrate that weight gain increases both adipocyte size and number, but the latter remains unaltered after weight loss. Transcriptome analyses associate changes in adipocyte number with the expression of 79 genes. This gene set is enriched for growth factors, out of which one, transforming growth factor-β3 (TGFβ3), stimulates adipocyte progenitor proliferation, resulting in a higher number of cells undergoing differentiation in vitro. The relevance of these observations was corroborated in vivo where Tgfb3+/- mice, in comparison with wild-type littermates, display lower subcutaneous adipocyte progenitor proliferation, WAT hypertrophy, and glucose intolerance. TGFβ3 is therefore a regulator of subcutaneous adipocyte number and may link WAT morphology to glucose metabolism
Measurement of inclusive D*+- and associated dijet cross sections in photoproduction at HERA
Inclusive photoproduction of D*+- mesons has been measured for photon-proton
centre-of-mass energies in the range 130 < W < 280 GeV and a photon virtuality
Q^2 < 1 GeV^2. The data sample used corresponds to an integrated luminosity of
37 pb^-1. Total and differential cross sections as functions of the D*
transverse momentum and pseudorapidity are presented in restricted kinematical
regions and the data are compared with next-to-leading order (NLO) perturbative
QCD calculations using the "massive charm" and "massless charm" schemes. The
measured cross sections are generally above the NLO calculations, in particular
in the forward (proton) direction. The large data sample also allows the study
of dijet production associated with charm. A significant resolved as well as a
direct photon component contribute to the cross section. Leading order QCD
Monte Carlo calculations indicate that the resolved contribution arises from a
significant charm component in the photon. A massive charm NLO parton level
calculation yields lower cross sections compared to the measured results in a
kinematic region where the resolved photon contribution is significant.Comment: 32 pages including 6 figure
Measurement of the diffractive structure function in deep inelastic scattering at HERA
This paper presents an analysis of the inclusive properties of diffractive
deep inelastic scattering events produced in interactions at HERA. The
events are characterised by a rapidity gap between the outgoing proton system
and the remaining hadronic system. Inclusive distributions are presented and
compared with Monte Carlo models for diffractive processes. The data are
consistent with models where the pomeron structure function has a hard and a
soft contribution. The diffractive structure function is measured as a function
of \xpom, the momentum fraction lost by the proton, of , the momentum
fraction of the struck quark with respect to \xpom, and of . The \xpom
dependence is consistent with the form \xpoma where
in all bins of and
. In the measured range, the diffractive structure function
approximately scales with at fixed . In an Ingelman-Schlein type
model, where commonly used pomeron flux factor normalisations are assumed, it
is found that the quarks within the pomeron do not saturate the momentum sum
rule.Comment: 36 pages, latex, 11 figures appended as uuencoded fil
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