Parental socialization styles as a predictor of suicidal ideation in high school students

Objective: To know if there is a significant difference between the types of maternal vs. paternal parental socialization and if they are predictors of suicidal ideation in students of  Ignacio Carrillo Franco (ICF) Preparatory School, May 2017.  Material and methods: Observational, transversal, prospective study. The studiend population was the high school students ICF. The parental socialization styles of both parents were measured using the ESPA-29 scale and the suicidal ideation (Roberts scale) of the students. Descriptive and inferential statistics were performed using ANOVA and multiple linear regression with the IBM SPSS Statistics 20 program.  Results: There were 144 students, aged 15-17 (m16.31 ± SD 0.68). The maternal parental socialization style (Negligent vs Authoritarian Games-Howell m: 1.84, SD 0.57, Sig .011) shows significant difference vs paternal and maternal axes Acceptance/Implication (t: -2.85, Sig .005), Coercion/ Imposition (t 3.35, Sig .001), maternal dysplication (t 5.913, Sig .000) and paternal (t 3.343, Sig 0.001) are predictors of suicidal ideation.  Discussion: The mother plays the most important role in the suicidal ideation of adolescents; since according to their parental style they are the most predicted.  Key words: Styles of parental socialization, suicidal ideation, adolescents

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality