Severe community-acquired adenovirus pneumonia in an immunocompetent 44-year-old woman: a case report and review of the literature

<p>Abstract</p> <p>Introduction</p> <p>This case report describes a rare condition: community-acquired adenovirus pneumonia in an immunocompetent adult. The diagnosis was achieved by using a multiplex real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay and highlights the usefulness of these novel molecular diagnostic techniques in patients hospitalized with acute respiratory illness. We also performed a literature search for previously published cases and present a summary of the clinical, laboratory and radiological features of this condition.</p> <p>Case presentation</p> <p>A 44-year-old immunocompetent Caucasian woman was admitted to our hospital with an acute febrile respiratory illness associated with a rash. Her blood tests were non-specifically abnormal, and tests for bacterial pathogens were negative. Her condition rapidly deteriorated while she was in our hospital and required mechanical ventilation and inotropic support. A multiplex real-time RT-PCR assay performed on respiratory specimens to detect respiratory viruses was negative for influenza but positive for adenovirus DNA. The patient recovered on supportive treatment, and antibiotics were stopped after 5 days.</p> <p>Conclusions</p> <p>Community-acquired adenovirus pneumonia in immunocompetent adult civilians presents as a non-specific acute febrile respiratory illness followed by the abrupt onset of respiratory failure, often requiring mechanical ventilation. Its laboratory and radiological features are typical of viral infections but also are non-specific. Novel multiplex real-time RT-PCR testing for respiratory viruses enabled us to rapidly make the diagnosis in this case. The new technology could be used more widely in patients with acute respiratory illness and has potential utility for rationalization of the use of antibiotics and improving infection control measures.</p

Holocaust archaeology: archaeological approaches to landscapes of Nazi genocide and persecution

The landscapes and material remains of the Holocaust survive in various forms as physical reminders of the suffering and persecution of this period in European history. However, whilst clearly defined historical narratives exist, many of the archaeological remnants of these sites remain ill-defined, unrecorded and even, in some cases, unlocated. Such a situation has arisen as a result of a number of political, social, ethical and religious factors which, coupled with the scale of the crimes, has often inhibited systematic search. This thesis will outline how a non-invasive archaeological methodology has been implemented at two case study sites, with such issues at its core, thus allowing them to be addressed in terms of their scientific and historical value, whilst acknowledging their commemorative and religious significance. In doing so, this thesis also demonstrates how a study of the physical remains of the Holocaust can reveal as much about the ever-changing cultural memory of these events as it can the surviving remnants of camps, execution sites and other features associated with this period. By demonstrating the diversity and complexity of Holocaust landscapes, a case is presented for a sub-discipline of Holocaust Archaeology