Impact of Reproductive Status and Age on Response of Depressed Women to Cognitive Therapy

Previous research suggests that reproductive hormones are potential affective modulators in mood disorders and may influence response to antidepressant medications. To our knowledge, there are no data on relationships between hormonal status and response to psychotherapy for recurrent major depressive disorder (MDD)

Packed Red Blood Cell Transfusion Associates with Acute Kidney Injury After Transcatheter Aortic Valve Replacement

Background: Acute kidney injury after cardiac surgery significantly associates with morbidity and mortality. Despite not requiring cardiopulmonary bypass, transcatheter aortic valve replacement patients have an incidence of post-procedural acute kidney injury similar to patients who undergo open surgical aortic valve replacement. Packed red blood cell transfusion has been associated with morbidity and mortality after cardiac surgery. We hypothesized that packed red blood cell transfusion independently associates with acute kidney injury after transcatheter aortic valve replacement, after accounting for other risk factors. Methods: This is a single-center retrospective cohort study of 116 patients undergoing transcatheter aortic valve replacement. Post-transcatheter aortic valve replacement acute kidney injury was defined by Kidney Disease: Improving Global Outcomes serum creatinine-based criteria. Univariate comparisons between patients with and without post-transcatheter aortic valve replacement acute kidney injury were made for clinical characteristics. Multivariable logistic regression was used to assess independent association of packed red blood cell transfusion with post-transcatheter aortic valve replacement acute kidney injury (adjusting for pre-procedural renal function and other important clinical parameters). Results: Acute kidney injury occurred in 20 (17.2%) subjects. Total number of packed red blood cells transfused independently associated with post-procedure acute kidney injury (OR = 1.67 per unit, 95% CI 1.13–2.47, P = 0.01) after adjusting for pre-procedure estimated glomerular filtration rate (OR = 0.97 per ml/min/1.73m2, 95% CI 0.94–1.00, P = 0.05), nadir hemoglobin (OR = 0.88 per g/dL increase, CI 0.61–1.27, P = 0.50), and post-procedure maximum number of concurrent inotropes and vasopressors (OR = 2.09 per inotrope or vasopressor, 95% CI 1.19–3.67, P = 0.01). Conclusion: Packed red blood cell transfusion, along with post-procedure use of inotropes and vasopressors, independently associate with acute kidney injury after transcatheter aortic valve replacement. Further studies are needed to elucidate the pathobiology underlying these associations

Coverage estimation of bootstrap confidence regions in R2

Includes bibliographical references (pages [15]-16).Confidence sets are constructed in almost any statistical analysis. Both parametric and nonparametric approaches can be taken to construct a confidence set for a parameter [theta]. In the one dimensional case, a disjoint interval is essentially the only form available for a confidence set, and construction of such an interval has been extensively studied. For the multiparameter case, the problem is not that simple, as the question of shape of the set arises and very few alternatives to the normal approximation method are available. One alternative is to use bootstrap theory to construct such confidence sets for parameter vector. These methods are yet to be studied empirically for comparison purposes in terms of coverage accuracy. This thesis represents an effort to focus on the empirical performance of some of the bootstrap methods available for construction of confidence sets for a vector parameter.M.S. (Master of Science

Legislative Documents

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Total Payments received by editors in each specialty.

<p>Blue columns–Chief editors; Red diamond-mean; Black line–median.</p

The number of editors in each specialty, and percentage of editors receiving general payments.

<p>The number of editors in each specialty, and percentage of editors receiving general payments.</p

The type of general payments made to editors in each payment category.

<p>The type of general payments made to editors in each payment category.</p

Total Payments received by the chief editors and associate editors in each specialty.

<p>Blue columns–Chief editors; Red Columns- Associate Editors; Black line-median.</p