Representative ERG findings for experimental eyes (bold traces) 4 weeks after challenge for all IOP levels.

<p>Selected stimulus conditions are shown to emphasize various components of the ERG: scotopic threshold response (STR, −5.55 log cd s m⁻², Column <b>A</b>) the scotopic bright flash ERG (2.22 log cd s m⁻², Column <b>B</b>) and OPs (Column <b>C)</b>, as well as the photopic ERG (2.72 log cd s m⁻², Column <b>D</b>) and Ops (Column <b>E</b>). ERG responses for fellow control eyes are shown by the thin traces in each column. IOP levels are indicated on the left.</p

Relative change across ERG components 4 weeks following acute IOP insult.

<p>(<b>A</b>) nSTR (filled triangles), P2 amplitude (V<i>_max</i>, open circles) and photoreceptoral amplitude (Rm<i>_P3</i>, filled squares). For comparison, the corresponding best-fit cumulative normal functions are also plotted in panel A for the nSTR (thin solid curve), P2 (V<i>_max</i>, dashed curve) and a-wave (Rm<i>_P3</i>, bold curve). (<b>B</b>) Scotopic OP amplitude. (<b>C</b>) Photopic b-wave amplitude (V<i>_max</i>, open diamonds) and photopic OP amplitude (filled diamonds). For clarity, the best-fit cumulative normal functions are omitted from panels B and C.</p

Representative individual examples of ERG findings 4 weeks after acute IOP elevation for selected groups.

<p>ERG responses for experimental eyes (bold traces) and their fellow control eyes (thin traces) are shown for the following groups: sham (Column <b>A</b>), 70 mmHg (Column <b>B</b>), 80 mmHg (Column <b>C</b>) and 100 mmHg (Column <b>D</b>). Stimulus flash intensities are listed at left for scotopic (below) and photopic (above) responses. Isolated OPs are shown to the right of corresponding waveforms.</p

ERG component amplitudes recorded during acute IOP elevation vs.

<p><b>after 4 weeks recovery.</b> Group mean relative amplitude (ratio of treated/fellow control eyes, %, filled symbols, ± SEM) for (<b>A</b>) a-wave (Rm<i>_P3</i>, P3), (<b>B</b>) b-wave (V<i>_max</i>, P2), (<b>C</b>) nSTR, (<b>D</b>) nSTR, (<b>E</b>) Photopic b-wave (V<i>_max</i>, P2) and (<b>F</b>) photopic OP components 4 weeks following acute IOP elevation for each level of IOP (solid curves represent best-fit cumulative normal functions). For comparison, the relative amplitudes of each component recorded during acute IOP elevation are re-plotted from a previous report <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070513#pone.0070513-Bui1" target="_blank">[20]</a> (unfilled symbols, dashed curves represent best-fit cumulative normal functions).</p

Recovery of ERG components as a function of stimulus intensity.

<p>Averaged group (± SEM) data for control eyes (unfilled symbols) and experimental eyes (filled symbols).</p

Cumulative normal parameters for relative amplitude as a function of acute IOP.

*<p>significant recovery p<0.05 compared with acute from non-parametric bootstrap.</p