Atopic Dermatitis Host and Environment Model: Revisiting Therapeutic Options

Atopic Dermatitis affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of its triggers and includes emollients, topical steroids and calcineurin inhibitors among others. Immunological dysfunction can be addressed broadly with systemic immunosupressors and specifically with monoclonal antibodies. Dupilumab, which targets IL-4 and IL-13 was granted approval for treatment of moderate-to-severe AD. Biologics targeting IgE/Th2 pathways may have its role in patients with overlapping AD and asthma. Psychological distress can exacerbate symptoms and is associated with increased severity of AD. Environmental triggers, such as, allergens can be addressed in selected cases with allergic immunotherapy. In this paper, we discuss AD treatment and propose a new step-by-step approach aiming at maintaining disease control and improving quality of life.info:eu-repo/semantics/publishedVersio

A model-independent analysis of the dependence of the anomalous J/psi suppression on the number of participant nucleons

A recently published experimental dependence of the J/psi to Drell-Yan ratio on the measured, by a zero degree calorimeter, forward energy E_ZDC in Pb+Pb collisions at the CERN SPS is analyzed. Using a model-independent approach it is shown that the data are at variance with an earlier published experimental dependence of the same quantity on the transverse energy of neutral hadrons E_T. The discrepancy is related to a moderate centrality region: 100 < N_p < 200 (N_p is the number of participant nucleons) and is peculiar only to the data obtained within the `minimum bias' analysis (using the `theoretical Drell-Yan'). This could result from systematic experimental errors in the minimum bias sample. A possible source of the errors is discussed.Comment: 10 pages, LaTeX, 3 PS-figures. V2: Misprints are correcte

Magnetic effects on spontaneous symmetry breaking/restoration in a toroidal topology

We study temperature and finite-size effects on the spontaneous symmetry breaking/restoration for a scalar field model under the influence of an external magnetic field, at finite chemical potential. We use the 2PI formalism and consider the large-$N$ limit. We find that there is a minimal size of the system to sustain the broken phase, which diminishes as the applied field increases but is independent of the chemical potential. We analyze the critical curves and show that the magnetic field enhances the broken-phase regions, while increasing the chemical potential leads to a diminishement of the critical temperature.Comment: Five pages, five figures, version as accepted for publication in Phys. Rev.

Gauge Fluctuations in Superconducting Films

In this paper we consider a superconducting film modeled by the Ginzburg-Landau model, confined between two parallel planes a distance $L$ apart from one another. Our approach is based on the Gaussian effective potential in the transverse unitarity gauge, which allows to treat gauge contributions in a compact form. Using techniques from dimensional and $zeta$-function regularizations, modified by the confinement conditions, we investigate the critical temperature as a function of the film thickness $L$. The contributions from the scalar self-interaction and from the gauge fluctuations are clearly identified. The model suggests the existence of a minimal critical thickness below which superconductivity is suppressed.Comment: 6 pages Revtex, no figure

Lagrangian formulation for noncommutative nonlinear systems

In this work we use the well known formalism developed by Faddeev and Jackiw to introduce noncommutativity within two nonlinear systems, the SU(2) Skyrme and O(3) nonlinear sigma models. The final result is the Lagrangian formulations for the noncommutative versions of both models. The possibility of obtaining different noncommutative versions for these nonlinear systems is demonstrated.Comment: 8 pages. Revex 4.

The stellar host in star-forming low-mass galaxies: Evidence for two classes

The morphological evolution of star-forming galaxies provides important clues to understand their physical properties, as well as the triggering and quenching mechanisms of star formation. We aim at connecting morphology and star-formation properties of low-mass galaxies (median stellar mass $\sim$ 10$^{8.5}$ M$_{\odot}$) at low redshift ($z<0.36$). We use a sample of medium-band selected star-forming galaxies from the GOODS-North field. H$\alpha$ images for the sample are created combining both spectral energy distribution fits and HST data. Using them, we mask the star forming regions to obtain an unbiased two-dimensional model of the light distribution of the host galaxies. For this purpose we use $\texttt{PHI}$, a new Bayesian photometric decomposition code. We apply it independently to 7 HST bands assuming a S\'ersic surface brightness model. Star-forming galaxy hosts show low S\'ersic index (with median $n$ $\sim$ 0.9), as well as small sizes (median $R_e$ $\sim$ 1.6 kpc), and negligible change of the parameters with wavelength (except for the axis ratio, which grows with wavelength). Using a clustering algorithm, we find two different classes of star-forming galaxies: A more compact, redder, and high-$n$ (class A) and a more extended, bluer and lower-$n$ one (class B). We also find evidence that the first class is more spheroidal-like. In addition, we find that 48% of the analyzed galaxies present negative color gradients (only 5% are positive). The host component of low-mass star-forming galaxies at $z<0.36$ separates into two different classes, similar to what has been found for their higher mass counterparts. The results are consistent with an evolution from class B to class A. Several mechanisms from the literature, like minor and major mergers, and violent disk instability, can explain the physical process behind the likely transition between the classes. [abridged]Comment: Accepted for publication in Astronomy & Astrophysics. 13 pages, 11 figure