7 research outputs found

    Defining of the energy poverty of the state through the analysis of Belt and Road influence on its alleviation in the context of sustainable development

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    Energy poverty is an issue, which is new to the scientific field and often omitted from the research. The contemporary approaches to it are various, still the major of them points that energy poverty exists in case the national energy sector and the economy in general lack the possibilities to provide sufficient, safe, reliable, and affordable energy to the consumers. This paper examines the energy sector of Pakistan to prove or refute the idea of energy poverty existence in the country. In addition to that the energy poverty in Pakistan, in case it exists needs to be defined, its reasons are to be examined and the possible solutions for its alleviation provided. The paper proves the mentioned idea with the help of the approach from the side of international infrastructure construction. The proposed approach includes the examination of the role of BRI in energy poverty alleviation in Pakistan. While the Initiative has a significant impact on the economy of the country, its energy sector isnā€™t directly affected by BRI. The major results of the study encompass the following: the energy poverty measurement through index method is developed, based on demand for energy and its supply and importsā€™ changes; the energy poverty in Pakistan persists and canā€™t be alleviated by the international institutions; the effects of economic growth arenā€™t automatically distributed in the economy, especially in the energy sector of the country and have limited effects on energy poverty

    Causes of the Resurrection of a Positive Image of Stalin in Today's Russia: Its Historical Background and Putin's Strategy of Maneuvering People's Perceptions

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    Integrated genomic characterization of endometrial carcinoma

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    We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ~25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.National Institutes of Health (U.S.) (Grant 5U24CA143799-04)National Institutes of Health (U.S.) (Grant 5U24CA143835-04)National Institutes of Health (U.S.) (Grant 5U24CA143840-04)National Institutes of Health (U.S.) (Grant 5U24CA143843-04)National Institutes of Health (U.S.) (Grant 5U24CA143845-04)National Institutes of Health (U.S.) (Grant 5U24CA143848-04)National Institutes of Health (U.S.) (Grant 5U24CA143858-04)National Institutes of Health (U.S.) (Grant 5U24CA143866-04)National Institutes of Health (U.S.) (Grant 5U24CA143867-04)National Institutes of Health (U.S.) (Grant 5U24CA143882-04)National Institutes of Health (U.S.) (Grant 5U24CA143883-04)National Institutes of Health (U.S.) (Grant 5U24CA144025-04)National Institutes of Health (U.S.) (Grant U54HG003067-11)National Institutes of Health (U.S.) (Grant U54HG003079-10)National Institutes of Health (U.S.) (Grant U54HG003273-10
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