ASSESSMENT OF THE CURRENT STATE OF THE AGRICULTURAL STRUCTURE OF ARGENTINA

Background. Argentina is one of the largest and most developed socio-economic countries in Latin America. The use of modern agricultural technologies in the Argentine plains and new methods of shipping allowed Argentina to start exporting agricultural products to Europe. A series of commodity booms enriched Argentina and made it one of the largest economies in the world at the beginning of the 20th century. Purpose is to analyze and identify problems and prospects for the development of the agricultural structure in Argentina. Materials and methods. In the study, the authors used analytical materials of the UN Economic Commission and other international organizations on the countries of Latin America, reviews and reports of the Central Bank, the Institute of Statistics, the Ministry of Economy and Public Finance, the Ministry of Foreign Affairs. In this work, dialectical, systemic, historical, logical, formal-legal, comparative research methods were used. Results. Due to the abundance of appropriate land and natural resources, the favorable climate in most of the country and the generally low activity of pests, agricultural in Argentina is not particularly limited by natural conditions. However, there are a number of other factors that prevent Argentine farmers from fully operating as efficiently as possible. Conclusion. Argentina’s agro-industrial policy is quite contradictory. Despite the development of digital services and modern information technologies to support agricultural producers, the introduction of progressive export support programs, a fairly powerful infrastructure throughout the entire production cycle of agricultural products, the Argentine government from time to time resorts to using serious export barriers to maintaining the domestic market, which in general affects the Agar sector is not always positive

Pediatric encephalopathy: cinical, biochemical and cellular insights into the role of Gln52 of GNAO1 and GNAI1 for the dominant disease

Heterotrimeric G proteins are immediate transducers of G protein-coupled receptors—the biggest receptor family in metazoans—and play innumerate functions in health and disease. A set of de novo point mutations in GNAO1 and GNAI1, the genes encoding the α-subunits (Gαo and Gαi1, respectively) of the heterotrimeric G proteins, have been described to cause pediatric encephalopathies represented by epileptic seizures, movement disorders, developmental delay, intellectual disability, and signs of neurodegeneration. Among such mutations, the Gln52Pro substitutions have been previously identified in GNAO1 and GNAI1. Here, we describe the case of an infant with another mutation in the same site, Gln52Arg. The patient manifested epileptic and movement disorders and a developmental delay, at the onset of 1.5 weeks after birth. We have analyzed biochemical and cellular properties of the three types of dominant pathogenic mutants in the Gln52 position described so far: Gαo[Gln52Pro], Gαi1[Gln52Pro], and the novel Gαo[Gln52Arg]. At the biochemical level, the three mutant proteins are deficient in binding and hydrolyzing GTP, which is the fundamental function of the healthy G proteins. At the cellular level, the mutants are defective in the interaction with partner proteins recognizing either the GDP-loaded or the GTP-loaded forms of Gαo. Further, of the two intracellular sites of Gαo localization, plasma membrane and Golgi, the former is strongly reduced for the mutant proteins. We conclude that the point mutations at Gln52 inactivate the Gαo and Gαi1 proteins leading to aberrant intracellular localization and partner protein interactions. These features likely lie at the core of the molecular etiology of pediatric encephalopathies associated with the codon 52 mutations in GNAO1/GNAI1

The Institutional Foundations of the Digital Economy in the 21st Century/ Elena G. Popkova, Artem Krivtsov, Aleksei V. Bogoviz.

In English.The development of the Digital Economy has been a landmark breakthrough for economic systems in the 21st century, as it opens up opportunities for the full-scale implementation of new digital technologies and the optimization of economic activities. While the conceptual essence and specific features of the digital economy are described in detail in the existing literature, the practical foundations of its formation are poorly studied. In this book, the digital economy is studied from the perspective of neo-institutional economic theory. This allows for the tracking of the process of formation (institutionalization) of the digital economy, determining the basic institutions that are necessary for its formation and that exist in modern economic practice, and analyzing scenarios for the future development of the digital economy in the 21st century.Frontmatter -- Contents -- Digital Economy in the 21 Century: An Introduction to the Institutional Approach -- Part I: The Scientific Concept of the Digital Economy in the 21st Century -- 1 Digital Economy as a Modern Type of Economic System -- 2 “Digitalization”- Overcoming Institutional Barriers -- 3 Development of the Information Technologies Sector in Latvia under Globalization -- 4 The Principles of Functioning and Priorities of Development of the Digital Economy -- 5 Classification of Breakthrough Digital Technologies and the Perspectives of Their Application in Economy -- Part II: The Process of Digital Economy Institutionalization in the 21st Century -- 6 The Essence and Logic of the Process of Sectorial Markets' Digital Transformation -- 7 The Current Tendencies of Economy Digitalization in Developed and Developing Countries -- 8 The Main Stages of the Digital Modernization of Economy -- 9 Implementation of Cluster Initiatives in the Digital Sphere as a Tool of Digital Entrepreneurship's Institutionalization -- 10 Institutions of Support for Digital Entrepreneurship: Special Economic Zones, Innovative Networks and Technological Parks -- Part III: Meso-Level Institutions of the Digital Economy in the 21st Century -- 11 Digitalization of Regional Economy: Problems and Perspectives -- 12 The Institutional Model of the Digital Economy Creation in a Modern Region -- 13 Managing a Modern Region Based on Digital Technologies -- Part IV: Macro-Level Institutions of the Digital Economy in the 21st Century -- 14 State Institutional Regulation of Economy Digital Modernization -- 15 The Role of Financial Institutions in Supporting the Digital Economy -- 16 Digital Economy of the 21st Century: A View from the Positions of Developed and Developing Countries -- Part V: The Global Institutions of the Digital Economy in the 21st Century -- 17 International Trade in the Digital Sphere: Barriers and Prospects for Development -- 18 The Existing and Perspective International Institutions for Supporting Digital Transformation of Economy -- 19 The Scientific and Methodological Approach to Provision and Evaluation of the Digital Economy's Global Competitiveness -- 20 The Strategy of Optimal Development of the Digital Economy: A View from the Positions of Game Theory -- 21 The Institutional Model of Well-Balanced and Sustainable Digital Economy -- 22 The Institutional Mechanism of Managing the Digital Economy's Development -- Part VI: Case Studies of Institutions of the Digital Economy in the 21st Century -- 23 Problems and Prospects of Economic Cooperation Between Russia and Mexico -- 24 Innovative Critical Success Factors for Public - Private Partnerships (PPP) in Infrastructure Projects of Developing Countries. A Case of Zambia -- 25 Prediction Mechanism of the Territorial Socio-Economic Processes in Formation of the Information Systems -- 26 Specific Economic Security Regulations in the Context of Pathological Crises of Digital Transformation of Agricultural Organizations -- Conclusion: Institutional Perspectives of the Digital Economy's Development in the 21st Century -- List of Figures -- List of Tables -- Index.1 online resource (XI, 258 p.)