A Short Communication: Non-acid Nucleic Blood Multi-Factors Panels for Primary Breast Cancer Detection - A Systematic Review and Network Meta-Analysis

This study aimed to compare the non-acid nucleic blood multi-factor panels together and with mammography in terms of sensitivity, specificity, and accuracy in primary breast cancer detection (I, II, III, and IV). We systematically reviewed studies assessing non-acid nucleic blood tumor markers panels’ diagnostic value in both healthy women and patients (before any anticancer treatment) for the detection of primary breast cancer. Out of the 2358 titles initially identified, 12 studies and 9 panels were included in the network meta-analysis. Panels I (MSA + B2m) and J (GATA3 + E-cadherin) had the highest sensitivity in all stages of primary breast cancer but had no significant difference with mammography. Panels L (MSA + CA15–3) and B (M-CSF + CA15–3) had the highest specificity in all stages compared to other panels but no remarkable difference with mammography. Panels J (GATA3 + E-cadherin) and I (MSA + B2m) respectively had the highest accuracy in primary breast cancer detection but no considerable difference with mammography in terms of accuracy. Panel J, including GATA3 + E-cadherin, demonstrated a higher diagnostic value for primary breast cancer detection (I, II, III, and IV) than the rest of the panels

A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years

Background: Esophageal-cancer is the seventh most common-cause of cancer-related-deaths in men. Cytochrome-P450-family-1-subfamily-B-polypeptide-1 (CYP1B1) plays a role in the metabolism of xenobiotics, and is associated with several cancers. Here we investigated the association between a genetic-variant, CYP1B1-rs1056836, with the clinical-characteristics of patients with esophagus-squamous-cell-carcinoma (ESCC). Method: 117-patients with ESCC and 208 healthy-subjects were recruited. DNA was extracted and genotyped. Kaplan-Meier curves were utilized to assess overall and progression-free survival. The relationship between clinicopathological-data, disease-prognosis, and survival, were evaluated with the genotypes. Results: the genotypic frequency for GG, GC, and CC were 58.6%, 29.8%, 11.5% respectively in the healthy subjects and 51.8%, 36.14% and 12% in the ESCC group. An association between the GG genotype and stage of ESCC was found. Conclusion: Our findings suggest a relationship between the CYP1B1-rs1056836 genetic polymorphism and clinical features of ESCC, supporting further studies in larger-populations in different-ethnic groups, taking into account potentially important environmental-factors

The effect of presenting surgical case reports on self-confidence and clinical self-efficacy of operating room students

Introduction: Self-confidence and self-efficacy are two important factors for improving the clinical competence of paramedical students. The aim of this study was to investigate the effect of presenting surgical case report on self-confidence and clinical self-efficacy of operating room students. Methods: This is a semi-experimental study of two-group, which was conducted on 60 operating room students at Isfahan University of Medical Sciences in 2018. Students were randomly divided into two experimental and control groups using easy sampling method. In the experimental group, case-report peresentation was performed on the day of surgery and presented daily during the course of the training. Pre-test and post-test were performed by clinical self-efficacy and self-confidence questionnaires in two groups before and after the intervention. Statistical tests were t-test, paired t test, chi-square test and Mann–Whitney. Results: The mean of self-efficacy and self-confidence before intervention was not significantly different between the two groups (P>0.05). mean and standard deviation of self-efficacy after intervention in the experimental group were (42.18±8.27) that was significantly higher than control group (34.31±18.90) (P<0.05) (t=2.09). Also, the mean and standard deviation of self-esteem after intervention in the experimental group were (20.53±5.27) that was significantly higher than control group (15.30±8.70) (P<0.05) (t=2.82). Conclusion: The results indicate that reporting the surgical procedures and presenting them during the internship period has improved clinical self-efficacy and confidence of operating room students. Accordingly, applying educational aids can improve clinical performance