Urbanization of Information Systems as a Trigger for enhancing Agility: A State in The Tunisian Firms

Nowadays, the information Systems (IS) became one of the main assets of modern corporations, but it faces many problems. Among the most important are low productivity and a large number of failures like obsolescence, heavier, slower and complexity of applications integration. The problem of low productivity of IS was the product of the software crisis, as indicated by the delayed development and implementation of ISs and accumulation which leads to maintenance problems. Requests for new or improved version of the IS have grown faster than the ability of the Chief Information Officer (CIO) to develop the existing IS. Some reasons are: the increase in the cost of software development and the IT choices of the CIO. All the above problems are further exacerbated by the growing complexity and size of software products. The IS is obliged to overcome these difficulties and ensure its evolution. To do this, urbanization is a framework that aims to simplify the IS, to improve communication between its components and to ensure its evolution. In an exploratory approach, this study examines the concept of urbanization studying its impact on the IS to ascertain agility. This was done in order to ascertain the evolution of IS and guarantee the agility facing the environment turbulence. The general assertion is that the Urbanized Information Systems (UIS) changes a firm vision because its procure flexibility, reactivity and interoperability of UIS. The originality of this paper is to explore IS urbanization considered as a French framework of Enterprise Architecture (EA), this study is an empirical validation of the agility of UIS. Keywords Information Systems, Urbanization, Enterprise Architecture (EA), flexibility, Agilit

Open Data in North Africa: Realities and Perspectives

International audienc

Open Data in North Africa: Realities and Perspectives

International audienc

Leberagin-C, A disintegrin-like/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion.

International audienceLeberagin-C, a new member of the disintegrin-like/cysteine-rich (D/C) family, was purified to homogeneity from the venom of Tunisian snake Macrovipera lebetina transmediterranea. It is a monomeric protein with a molecular mass of 25,787 Da. Its complete sequence of 205 amino acid residues was established by cDNA cloning. The leberagin-C shows many conserved sequences with other known D/C proteins, like the SECD binding sites and a pattern of 28 cysteines. It is the first purified protein from M. lebetina transmediterranea with only two disintegrin-like/cysteine-rich domains. Leberagin-C is able to inhibit platelet aggregation induced by thrombin and arachidonic acid with IC(50) of 40 and 50 nM respectively. It was also able to inhibit the adhesion of melanoma tumour cells on fibrinogen and fibronectin, by interfering with the function of alphavbeta3 and, to a lesser extent, with alphavbeta6 and alpha5beta1 integrins. To our knowledge, leberagin-C is the sole described D/C protein that does not specifically interact with the alpha2beta1 integrin. Structure-activity relationship study of leberagin-C suggested that there are some important amino acid differences with jararhagin, the most studied PIII metalloprotease from Bothrops jararaca, notably around the SECD motif in its disintegrin-like domain. Other regions implicated in leberagin-C specificities could not be excluded