On the microstructure and texture of Cu-Cr-Zr alloy after severe plastic deformation by ECAP

Samples of a commercial Cu-1Cr-0.1Zr (wt.%) alloy were subjected to severe plastic deformation at room temperature using equal-channel angular pressing (ECAP) up to 16 passes via route Bc. The microstructure and texture of the processed samples were analyzed through electron backscatter diffraction (EBSD). Most of the grains were more or less inclined in the direction of shearing (45° from the extrusion direction) and substantially refined. The deformation structure evolved from elongated grains to a duplex equiaxed-elongated microstructure upon straining. The fraction of high angle boundaries gradually increased with the number of passes up to 70%. The texture after ECAP was mainly of ECAP shear type whose components shifted slightly from their ideal positions. A net strengthening and stabilization of the B/View the MathML sourcecomponents were observed.Peer ReviewedPostprint (author's final draft

Etude par nanoindentation des proprietes mecaniques du multicouche constituant une cellule solaire a base de cigs

Le but de notre travail est d'évaluer les propriétés mécaniques des différentes couches constituant une cellule solaire à base de CIGS afin d'en appréhender, à terme, leur influence sur la durée de vie de la cellule. Nous rapportons principalement les valeurs de la dureté et le module de Young obtenues par des mesures de nanoindentation

Development of High-Throughput Platforms for Single-Cell Analysis

Thesis: S.M., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2015.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 85-90).Many important areas of research regarding human health, such as immunology and cancer biology, deal with highly heterogeneous populations of cells where the contributions of individual players cannot be ignored. Single-cell technologies aim to resolve this heterogeneity by analyzing many individual cells in a high-throughput manner. Here we developed two examples of such tools that rely on microfabricated arrays of microwells. The first platform merges fluorescence cytometry with label-free profiling of the small molecule composition of tens of thousands of cells based on matrix assisted laser desorption/ionization (MALDI) mass spectrometry. We evaluated several materials and approaches to chip fabrication suitable for interfacing with a MALDI instrument. We also developed an analytical pipeline for efficient processing of cells on the chip and demonstrated its application to the analysis of brain tumor samples. The second platform provides a new format of microwell arrays for fluorescence cytometry that improves their compatibility with a range of automated equipment and enables more efficient processing of a greater number of samples, while preserving viability and identity of cells for subsequent analyses. We demonstrated its utility for on-chip enrichment and recovery of circulating tumor cells (CTCs) and high-content immuno phenotyping of small clinical samples.by Denis Loginov.S.M