Evaluating How Potential Pool of Partners Can Join Together in Different Types of Long Term Collaborative Networked Organizations

International audienceThe considerable benefits brought up by strategic alliances and diverse types of long term Collaborative Networked Organizations (CNOs) are nowadays widely recognized. There is an increasing demand in the industrial world for concretely implement new forms of collaborations. For example, demand often comes from pre-existent form of clusters or local productive arrangements, that want to evolve to more efficient forms of collaboration, or from small and medium enterprises that are facing a crisis, and look at collaboration with other enterprises as almost the last chance to survive. In general, variety of motivations in collaborating implies variety of missions of potential collaborations, that in turn requires the choice of an appropriate form of Collaborative Network aligned to the mission statement. This paper addresses the problem to define a methodology for analyzing potential pool of partners and for identifing the mission, the form, the governance structure and the value drivers of long term strategic alliance that would bring highest benefits to the partners. Three different forms of CNOs are considered: the Virtual organizations Breeding Environment (VBE), the Virtual Development Office (VDO) and the T-Holding

Why Research Partnerships Fail in the Biotechnology Sector — An Empirical Analysis of Strategic Partnerships

Over half of all research-oriented partnerships in the biotechnology industry fail due to problems in inter-organizational relationships. The analysis of factors that determine the success of strategic partnerships can help companies to reduce the high failure rates. Based on the resource-oriented and relationship-oriented approach, this study examines the influence of three structural factors and three dynamic factors on the success of strategic, research-oriented partnerships in the biotechnology industry. In the empirical study, data of 48 research collaborations by 28 companies were collected and analyzed. The results confirm the significant influence of the factors “complementary resources”, “operational compatibility”, “bilateral exchange of information” and “opportunistic behavior”. On the basis of these findings, companies can find approaches to influence the success of their own research collaborations. In particular, appropriate recommendations for action can be formulated in the areas of the structural design of partnerships and the dynamic exchange process

Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors

Peptide-derived protease inhibitors are an important class of compounds with the potential to treat a wide range of diseases. Herein, we describe the synthesis of a series of triazole- containing macrocyclic protease inhibitors pre-organized into a b-strand conformation and an evaluation of their activity against a panel of proteases. Acyclic azidoalkyne-based aldehydes are also evaluated for comparison. The macrocyclic peptidomimetics showed considerable activity towards calpain II, cathepsin L and S, and the 20S proteasome chymotrypsin-like activity. Some of the first examples of highly potent macrocyclic inhibitors of cathepsin S were identified. These adopt a well-defined b-strand geometry as shown by NMR spectroscopy, X-ray analysis, and molecular docking studies. © 2013 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim.Associated Grant:Australian Research Counci