Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report.

High-intensity focused ultrasound (HIFU) is an ablative treatment undergoing assessment for the treatment of benign and malignant disease. We describe the first reported intracavitary HIFU ablation for recurrent, unresectable and symptomatic cervical cancer.A 38 year old woman receiving palliative chemotherapy for metastatic cervical adenocarcinoma was offered ablative treatment from an intracavitary trans-rectal HIFU device (Sonablate® 500). Pre-treatment symptoms included vaginal bleeding and discharge that were sufficient to impede her quality of life. No peri-procedural adverse events occurred. Symptoms resolved completely immediately post-procedure, reappeared at 7 days, increasing to pre-procedural levels by day 30.This first time experience of intracavitary cervical HIFU suggests that it is feasible for palliation of advanced cervical cancer, with no early evidence of unexpected toxicity. Ethical approval had also been granted for the use of per-vaginal access if appropriate. This route, alone or in combination with the rectal route, may provide increased accessibility in future patients with a redesigned device more suited to trans-vaginal ablations.Intracavitary HIFU is a potentially safe procedure for the treatment of cervical cancer and able to provide symptomatic improvement in the palliative setting

Five-dimensional Monopole Equation with Hedge-Hog Ansatz and Abel's Differential Equation

We review the generalized monopole in the five-dimensional Euclidean space. A numerical solution with the Hedge-Hog ansatz is studied. The Bogomol'nyi equation becomes a second order autonomous non-linear differential equation. The equation can be translated into the Abel's differential equation of the second kind and is an algebraic differential equation.Comment: 4 pages, 4 figures, typos correcte

Fermion Masses and Mixing in Four and More Dimensions

We give an overview of recent progress in the study of fermion mass and flavor mixing phenomena. Mass matrix ansatze are considered within the SM and SUSY GUTs where some predictive frameworks based on SU(5) and SO(10) are reviewed. We describe a variety of schemes to construct quark mass matrices in extra dimensions focusing on four major classes: models with the SM residing on 3-brane, models with universal extra dimensions, models with split fermions and models with warped extra dimensions. We outline how realistic patterns of quark mass matrices could be derived from orbifold models in heterotic superstring theory. Finally, we address the fermion mass problem in intersecting D-branes scenarios, and present models with D6-branes able to give a good quantitatively description of quark masses and mixing. The role of flavor/CP violation problem as a probe of new physics is emphasized.Comment: a review based on seminars presented by S.K. in different places, 34 pages, late

Solitonic supersymmetry restoration

Q-balls are a possible feature of any model with a conserved, global U(1) symmetry and no massless, charged scalars. It is shown that for a broad class of models of metastable supersymmetry breaking they are extremely influential on the vacuum lifetime and make seemingly viable vacua catastrophically short lived. A net charge asymmetry is not required as there is often a significant range of parameter space where statistical fluctuations alone are sufficient. This effect is examined for two supersymmetry breaking scenarios. It is found that models of minimal gauge mediation (which necessarily have a messenger number U(1)) undergo a rapid, supersymmetry restoring phase transition unless the messenger mass is greater than 10^8 GeV. Similarly the ISS model, in the context of direct mediation, quickly decays unless the perturbative superpotential coupling is greater than the Standard Model gauge couplings.Comment: 17 pages, 3 figures, minor comments added, accepted for publication in JHE

Multiscale Gyrokinetics for Rotating Tokamak Plasmas: Fluctuations, Transport and Energy Flows

This paper presents a complete theoretical framework for plasma turbulence and transport in tokamak plasmas. The fundamental scale separations present in plasma turbulence are codified as an asymptotic expansion in the ratio of the gyroradius to the equilibrium scale length. Proceeding order-by-order in this expansion, a framework for plasma turbulence is developed. It comprises an instantaneous equilibrium, the fluctuations driven by gradients in the equilibrium quantities, and the transport-timescale evolution of mean profiles of these quantities driven by the fluctuations. The equilibrium distribution functions are local Maxwellians with each flux surface rotating toroidally as a rigid body. The magnetic equillibrium is obtained from the Grad-Shafranov equation for a rotating plasma and the slow (resistive) evolution of the magnetic field is given by an evolution equation for the safety factor q. Large-scale deviations of the distribution function from a Maxwellian are given by neoclassical theory. The fluctuations are determined by the high-flow gyrokinetic equation, from which we derive the governing principle for gyrokinetic turbulence in tokamaks: the conservation and local cascade of free energy. Transport equations for the evolution of the mean density, temperature and flow velocity profiles are derived. These transport equations show how the neoclassical corrections and the fluctuations act back upon the mean profiles through fluxes and heating. The energy and entropy conservation laws for the mean profiles are derived. Total energy is conserved and there is no net turbulent heating. Entropy is produced by the action of fluxes flattening gradients, Ohmic heating, and the equilibration of mean temperatures. Finally, this framework is condensed, in the low-Mach-number limit, to a concise set of equations suitable for numerical implementation.Comment: 113 pages, 3 figure

Chiral N=1 4d Orientifolds with D-branes at Angles

D6-branes intersecting at angles allow for phenomenologically appealing constructions of four dimensional string theory vacua. While it is straightforward to obtain non-supersymmetric realizations of the standard model, supersymmetric and stable models with three generations and no exotic chiral matter require more involved orbifold constructions. The T^6/(Z_4 x Z_2 x OmegaR) case is discussed in detail. Other orbifolds including fractional D6-branes are treated briefly.Comment: Invited brief review, 16 pages, 2 figures; references adde

Tree Level Metastability and Gauge Mediation in Baryon Deformed SQCD

We investigate supersymmetric QCD with gauge group SU(2) and a baryon deformation to the superpotential. The existence of an uplifted vacuum at the origin with tree level metastability is demonstrated. When this model is implemented in a direct gauge mediation scenario we therefore find gaugino masses which are comparable to sfermion masses and parameterised by an effective number of messengers 1/8. All deformations are well motivated by appealing to the electric theory and an R-symmetry. This R-symmetry is explicitly broken by the same term responsible for supersymmetry breaking. Moreover, the model does not suffer from the Landau pole problem and we find that it can be described in terms of just two scales: the weak scale and a high scale like the Planck or GUT scale. The model can be tested by searching for new particles at the TeV scale charged under the visible sector gauge group.Comment: 17 pages, 7 figures, updated reference

CP Violation beyond the Standard Model

In this talk a number of broad issues are raised about the origins of CP violation and how to test the ideas.Comment: 17 pages, LaTeX, 6 postscript figures. Uses iopart10.clo, iopart12.clo and iopart.cls. Plenary talk given at the BSM Phenomenology Workshop, Durham, UK, 6-11 May 2001. To appear in the proceeding

Open String Creation by S-Branes

An sp-brane can be viewed as the creation and decay of an unstable D(p+1)-brane. It is argued that the decaying half of an sp-brane can be described by a variant of boundary Liouville theory. The pair creation of open strings by a decaying s-brane is studied in the minisuperspace approximation to the Liouville theory. In this approximation a Hagedorn-like divergence is found in the pair creation rate, suggesting the s-brane energy is rapidly transferred into closed string radiation.Comment: Talk presented at the Hangzhou String 2002 Conference, August 12-1

Rotationally Warm Molecular Hydrogen in the Orion Bar

The Orion Bar is one of the nearest and best-studied photodissociation or photon-dominated regions (PDRs). Observations reveal the presence of H2 lines from vibrationally or rotationally excited upper levels that suggest warm gas temperatures (400 to 700 K). However, standard models of PDRs are unable to reproduce such warm rotational temperatures. In this paper we attempt to explain these observations with new comprehensive models which extend from the H+ region through the Bar and include the magnetic field in the equation of state. We adopt the model parameters from our previous paper which successfully reproduced a wide variety of spectral observations across the Bar. In this model the local cosmic-ray density is enhanced above the galactic background, as is the magnetic field, and which increases the cosmic-ray heating elevating the temperature in the molecular region. The pressure is further enhanced above the gas pressure in the H+ region by the momentum transferred from the absorbed starlight. Here we investigate whether the observed H2 lines can be reproduced with standard assumptions concerning the grain photoelectric emission. We also explore the effects due to the inclusion of recently computed H2 + H2, H2 + H and H2 + He collisional rate coefficients.Comment: Accepted for publication in ApJ (34 pages, including 16 figures