351 research outputs found
The Off Shell - Mixing in the QCD Sum Rules
The dependence of the mixing amplitude is analyzed with
the use of the QCD sum rules and the dispersion relation. Going off shell the
mixing decreases, changes sign at and is
negative in the space like region. Implications of this result to the isospin
breaking part of the nuclear force are discussed.Comment: 26 pages + 11 figures (PostScript
pi-NN Coupling Constants from NN Elastic Data between 210 and 800 Mev
High partial waves for and elastic scattering are examined
critically from 210 to 800 MeV. Non-OPE contributions are compared with
predictions from theory. There are some discrepancies, but sufficient agreement
that values of the coupling constants for exchange
and for charged exchange can be derived. Results are and , where the first error is statistical and the
second is an estimate of the likely systematic error, arising mostly from
uncertainties in the normalisation of total cross sections and
.Comment: 21 pages of LaTeX, UI-NTH-940
Off-Shell Rho-Omega Mixing Through Quark Loops With Non-Perturbative Meson Vertex And Quark Mass Functions
The momemtum dependence of the off-shell - mixing amplitude is
calculated through a two-quark loop diagram, using non-perturbative meson-quark
vertex functions for the and mesons, as well as
non-perturbative quark propagators. Both these quantities are generated
self-consistently through an interlinked BSE-cum-SDE approach with a 3D support
for the BSE kernel with two basic constants which are pre- checked against a
wide cross section of both meson and baryon spectra within a common structural
framework for their respective 3D BSE's. With this pre-calibration, the
on-shell strength works out at -2.434 in units of the change in
"constituent mass squared", which is consistent with the to
data for a u-d mass difference of ~4 MeV ,while the relative
off-shell strength (0.99 0.01) lies midway between quark-loop and QCD-SR
results. We also calculate the photon-mediated - propagator whose
off-shell structure has an additional pole at =0. The implications of
these results vis-a-vis related investigations are discussed.Comment: 12 Pages, latex file, NTUTH-94-0
Selected nucleon form factors and a composite scalar diquark
A covariant, composite scalar diquark, Fadde'ev amplitude model for the
nucleon is used to calculate pseudoscalar, isoscalar- and isovector-vector,
axial-vector and scalar nucleon form factors. The last yields the nucleon
sigma-term and on-shell sigma-nucleon coupling. The calculated form factors are
soft, and the couplings are generally in good agreement with experiment and
other determinations. Elements in the dressed-quark-axial-vector vertex that
are not constrained by the Ward-Takahashi identity contribute ~20% to the
magnitude of g_A. The calculation of the nucleon sigma-term elucidates the only
unambiguous means of extrapolating meson-nucleon couplings off the meson
mass-shell.Comment: 12 pages, REVTEX, 5 figures, epsfi
How the recent BABAR data for P to \gamma\gamma* affect the Standard Model predictions for the rare decays P to l+l-
Measuring the lepton anomalous magnetic moments and the rare decays
of light pseudoscalar mesons into lepton pairs , serve as
important tests of the Standard Model. To reduce the theoretical uncertainty in
the standard model predictions, the data on the charge and transition form
factors of the light pseudoscalar mesons play a significant role. Recently, new
data on the behavior of the transition form factors at
large momentum transfer were supplied by the BABAR collaboration. There are
several problems with the theoretical interpretation of these data: 1) An
unexpectedly slow decrease of the pion transition form factor at high momenta,
2) the qualitative difference in the behavior of the pion form factor and the
and form factors at high momenta, 3) the inconsistency of
the measured ratio of the and form factors with the
predicted one. We comment on the influence of the new BABAR data on the rare
decay branchings.Comment: 11 pages, 3 figure
Treatment of Branch Retinal Vein Occlusion induced Macular Edema with Bevacizumab
BACKGROUND: Branch retinal vein occlusion is a frequent cause of visual loss with currently insufficient treatment options. We evaluate the effect of Bevacizumab (Avastin) treatment in patients with macular edema induced by branch retinal vein occlusion. METHODS: Retrospective analysis of 32 eyes in 32 patients with fluorescein angiography proven branch retinal vein occlusion, macular edema and Bevacizumab treatment. Outcome measures were best corrected visual acuity in logMAR and central retinal thickness in OCT. RESULTS: Visual acuity was significantly better 4 to 6 weeks after Bevacizumab treatment compared to visual acuity prior to treatment (before 0.7 +/- 0.3 and after 0.5 +/- 0.3; mean +/- standard deviation; p < 0.01, paired t-test). Gain in visual acuity was accompanied by a significant decrease in retinal thickness (454 +/- 117 to 305 +/- 129 microm, p < 0.01, paired t-test). Follow up (170, 27 - 418 days; median, range) shows that improvement for both visual acuity and retinal thickness last for several months after Bevacizumab use. CONCLUSION: We present evidence that intravitreal Bevacizumab is an effective and lasting treatment for macular edema after branch retinal vein occlusion
Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode.
BACKGROUND
Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MSped) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGADped) in children > 6 years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of optical coherence tomography (OCT) in differentiating between both diseases after the first ON episode.
METHODS
Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls.
RESULTS
Thirteen MOGADped (10.7 ± 4.2 years, F:M 8:5, 21 ON eyes) and 21 MSped (14.3 ± 2.4 years, F:M 19:2, 24 ON eyes) patients were recruited. We observed a significantly more profound atrophy of both peripapillary and macular retinal nerve fiber layer in MOGADped compared to MSped (pRNFL global: 68.2 ± 16.9 vs. 89.4 ± 12.3 µm, p < 0.001; mRNFL: 0.12 ± 0.01 vs. 0.14 ± 0.01 mm3, p < 0.001). Neither other macular layers nor P100 latency differed. MOGADped developed global atrophy affecting all peripapillary segments, while MSped displayed predominantly temporal thinning. Nasal pRNFL allowed differentiation between both diseases with the highest diagnostic accuracy (AUC = 0.902, cutoff < 62.5 µm, 90.5% sensitivity and 70.8% specificity for MOGADped). OCT was also substantially more sensitive compared to VEP in identification of ON eyes in MOGAD (pathological findings in 90% vs. 14%, p = 0.016).
CONCLUSION
First MOGAD-ON results in a more severe global peripapillary atrophy compared to predominantly temporal thinning in MS-ON. Nasal pRNFL allows differentiation between both diseases with the highest accuracy, supporting the additional diagnostic value of OCT in children with ON
A protein functionalization platform based on selective reactions at methionine residues.
Nature has a remarkable ability to carry out site-selective post-translational modification of proteins, therefore enabling a marked increase in their functional diversity1. Inspired by this, chemical tools have been developed for the synthetic manipulation of protein structure and function, and have become essential to the continued advancement of chemical biology, molecular biology and medicine. However, the number of chemical transformations that are suitable for effective protein functionalization is limited, because the stringent demands inherent to biological systems preclude the applicability of many potential processes2. These chemical transformations often need to be selective at a single site on a protein, proceed with very fast reaction rates, operate under biologically ambient conditions and should provide homogeneous products with near-perfect conversion2-7. Although many bioconjugation methods exist at cysteine, lysine and tyrosine, a method targeting a less-explored amino acid would considerably expand the protein functionalization toolbox. Here we report the development of a multifaceted approach to protein functionalization based on chemoselective labelling at methionine residues. By exploiting the electrophilic reactivity of a bespoke hypervalent iodine reagent, the S-Me group in the side chain of methionine can be targeted. The bioconjugation reaction is fast, selective, operates at low-micromolar concentrations and is complementary to existing bioconjugation strategies. Moreover, it produces a protein conjugate that is itself a high-energy intermediate with reactive properties and can serve as a platform for the development of secondary, visible-light-mediated bioorthogonal protein functionalization processes. The merger of these approaches provides a versatile platform for the development of distinct transformations that deliver information-rich protein conjugates directly from the native biomacromolecules
Dominance and rarity in tree communities across the globe: Patterns, predictors and threats
Aim: Ecological and anthropogenic factors shift the abundances of dominant and rare tree species within local forest communities, thus affecting species composition and ecosystem functioning. To inform forest and conservation management it is important to understand the drivers of dominance and rarity in local tree communities. We answer the following research questions: (1) What are the patterns of dominance and rarity in tree communities? (2) Which ecological and anthropogenic factors predict these patterns? And (3) what is the extinction risk of locally dominant and rare tree species? Location: Global. Time period: 1990–2017. Major taxa studied: Trees. Methods: We used 1.2 million forest plots and quantified local tree dominance as the relative plot basal area of the single most dominant species and local rarity as the percentage of species that contribute together to the least 10% of plot basal area. We mapped global community dominance and rarity using machine learning models and evaluated the ecological and anthropogenic predictors with linear models. Extinction risk, for example threatened status, of geographically widespread dominant and rare species was evaluated. Results: Community dominance and rarity show contrasting latitudinal trends, with boreal forests having high levels of dominance and tropical forests having high levels of rarity. Increasing annual precipitation reduces community dominance, probably because precipitation is related to an increase in tree density and richness. Additionally, stand age is positively related to community dominance, due to stem diameter increase of the most dominant species. Surprisingly, we find that locally dominant and rare species, which are geographically widespread in our data, have an equally high rate of elevated extinction due to declining populations through large‐scale land degradation. Main conclusions: By linking patterns and predictors of community dominance and rarity to extinction risk, our results suggest that also widespread species should be considered in large‐scale management and conservation practices
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