Anaphylaxis in a Newborn Due to Ampicillin

Anaphylaxis, an allergic reaction that is rapid in onset, is rare in the neonatal period due to immaturity of the immunological system. A case of threeday- old male neonate with ampicillin-induced anaphylaxis is reported here. Although drug allergies are rare in newborns, due to their life-threaten features, close monitoring is important

Evaluation of the rate of thrombocytosis in lower respiratory tract and upper urinary system ınfections

Alt solunum yolu enfeksiyonları ve üst üriner sistem enfeksiyonlarında trombositoz oranlarının çıkarılması ve degerlendirilmesi amaçlanmıstır. Bu çalısmada “GATAHaydarpasa Egitim Hastanesi Çocuk Klinigi'nde” 1 Ocak 2006- 1 Ocak 2009 yılları arasında yatırılarak tedavi verilen 20 alt solunum yolu enfeksiyonu (ASYE) ve 22 üst üriner sistem enfeksiyonu (ÜÜSE) tanısı alan hastanın dosyaları retrospektif olarak incelendi. Reaktif trombositoz, genel olarak kabul gören trombosit sayısının 500.000/mm üzeri olması kabul edildi. Istatistiksel veriler SPSS 13.0 ile degerlendirildi. Çalısmamızda trombositoz tanı anında üst üriner sistem enfeksiyonlarında daha fazla bulundu (ASYE %25, ÜÜSE %36). Üst üriner sistem enfeksiyonlarında en sık üreyen mikroorganizma Escherichia coli (n:12 %54) olarak tespit edildi. Çalısmamızda, alt solunum yolu enfeksiyonu ve üst üriner sistem enfeksiyonunda tanı anında görülen reaktif trombositoz ile hastalık siddeti karsılastırılmıs, arasında istatistiksel olarak anlamlı bir iliski bulunamamıstır.To evaluate the rates of thrombocytosis in lower respiratory tract (LRTI) and upper urinary system infections (UUSI). In this study, rates of thrombocytosis were evaluated in patients hospitalized and treated with the diagnosis of LRTI (n=20) or UUSI (n=22) in “GATA Haydarpasa Teaching Hospital, Department of Pediatrics” between 2006-2009, retrospectively. Reactive thrombocytosis is defined as the platelet count over 500.000/mm . Statistical analysis was performed by SPSS forWindows version 13.0. p'0.05 was accepted as statistically significant. Thrombocytosis was found to be higher in the UUSI (%36) at the time of the diagnosis compared to the LRTI group (25%). The most common microorganism identified in the UUSI was Escherichia coli (n=12, 54%). There was no significant relationship between the reactive thrombocytosis observed at the time of the diagnosis and the severity of the disease in theLRTI and the UUSI

A Simple Procedure may Cause Severe Results

Capillary blood sampling via a heel puncture is a common procedure performed on hospitalized neonates. If not performed properly, a heelstick can lead to complications. The clinical and financial impact of complications can be significant. Also in some situations, the procedure could be complicated with skin infections, hematomes, soft tissue infections, arthritis and osteomyelitis. We report an infant complicated with arthitis and soft tissue infection secondary to heel puncture and we want to emphesize the importance of neonatal procedures

Important factors determining prognosis based on SUVmax in PET imaging

[No Abstract Available

Is 99mTc-MDP whole body bone scintigraphy adjuvant to 18F-FDG-PET for the detection of skeletal metastases?

Purpose: Due to the fact that fiuorine-18-fiuorodeoxyglucose positron emission tomography/computed tomography CSF-FDG-PET/CT) and technetium-99m- methylenediphosphonate (99mTc-MDP) whole body scans identify bone metastases by different mechanisms, i.e. by using glucose metabolism and osteoblastic response in the bone, respectively, it can be expected that there may be some differences between these two methods in the number of lesions identified. The aim of this study was to compare the sensitivity,specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) in detecting bone metastases between 18F-FDG-PET/CT and conventional 99mTc-MDP whole body scans. Methods: Between 2006-2009, 121 patients with malignancies (62 male and 59 female, mean age 59.3±10.8 years, range 37-84) were examined with 18F-FDG-PET/CT and conventional 99Tc-MDP whole-body scans for detection of bone metastases. Results: For 18F-FDG-PET/CT and for 99mTC-MDP, sensitivity, specificity, accuracy, PPV and NPV for detecting all studied bone metastases were 88.3, 83.6, 86.7, 91.7, 77.8% and 91.7, 71.0, 84.9, 86.6, 80.8%, respectively. For bone metastases of breast and lung cancers, the specificity and accuracy of PET/CT was higher than that of bone scintigraphy. On the other hand, the sensitivity of bone scintigraphy was higher than PET/CT in breast and lung cancers groups and all patients. In the detection of osteolytic and osteosclerotic metastases no difference was found between the two methods, while for osteolytic lesions the mean standardized uptake value (SUV) max was higher than for osteosclerotic lesions. Conclusion: For the detection of bone metastases the spesificity and accuracy of 18F-FDG-PET/CT were higher compared to bone scintigraphy, while the sensivity was lower. It is the opinion of the authors that both studies are complementary to final diagnosis

Is Tc-99m-MDP whole body bone scintigraphy adjuvant to F-18-FDG-PET for the detection of skeletal metastases?

Purpose: Due to the fact that fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG-PET/CT) and technetium-99m-methylenediphosphonate (Tc-99m-MDP) whole body scans identify bone metastases by different mechanisms, i.e. by using glucose metabolism and osteoblastic response in the bone, respectively, it can be expected that there may be some differences between these two methods in the number of lesions identified. The aim of this study was to compare the sensitivity,specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) in detecting bone metastases between F-18-FDG-PET/CT and conventional Tc-99m-MDP whole body scans. Methods: Between 2006-2009, 121 patients with malignancies (62 male and 59 female, mean age 59.3 +/- 10.8 years, range 37-84) were examined with F-18-FDG-PET/CT and conventional Tc-99-.MDP whole-body scans for detection of bone metastases. Results: For F-18-FDG-PET/CT and for (TC)-T-99m-MDP, sensitivity, specificity, accuracy, PPV and NPV for detecting all studied bone metastases were 88.3, 83.6, 86.7, 91.7, 77.8% and 91.7, 71.0, 84.9, 86.6, 80.8%, respectively. For bone metastases of breast and lung cancers, the specificity and accuracy of PET/CT was higher than that of bone scintigraphy. On the other hand, the sensitivity of bone scintigraphy was higher than PET/CT in breast and lung cancers groups and all patients. In the detection of osteolytic and osteosclerotic metastases no difference was found between the two methods, while for osteolytic lesions the mean standardized uptake value (SLIV) max was higher than for osteosclerotic lesions. Conclusion: For the detection of bone metastases the spesificity and accuracy of F-18-FDG-PET/CT were higher compared to bone scintigraphy, while the sensivity was lower. It is the opinion of the authors that both studies are complementary to final diagnosis

Approach to feeding problems in babies with cleft lip and/or palate

Dudak ve/veya damak yarığı en yaygın kraniyofasiyal doğumsal anomalilerden biri olup, en sık orofasiyal bölgede görülür. Yenidoğan bebeklerde bu doğumsal anomalinin görülme sıklığı %15 civarındadır. Bu konjenital malformasyonların patogenenezi tam olarak bilinmemekle beraber, hem beslenme hem de genetik faktörlerin rol oynadığına dair kanıtlar bulunmakta ve bu kanıtlar gün geçtikçe artmaktadır. Dudak ve/veya damak yarığı olan çocuklar, doğumdan sonra beslenme güçlükleri nedeniyle yetersiz beslenebilirler. Bu deformitelere sahip çocukların büyümesi genellikle sağlıklı çocuklara kıyasla bozulmuştur. Bu bebeklerin değerlendirilmesi için multidisipliner bir yaklaşım zorunludur. Başlangıçta dudak ve/veya damak yarığı olan yenidoğanların beslenmesi ebeveynler için büyük bir endişe kaynağıdır. Emzirme, modifiye edilmiş biberonlar ve/veya meme ucu, tıkayıcı plakalar ve anne danışmanlığı ve destek gibi beslenme müdahalelerine ihtiyaç duyulur. Bu yazıda, bu konudaki bazı beslenme sorunlarının ve uyarlamalarının gözden geçirilmesi amaçlanmıştır.Cleft lip and/or palate is one of the most common craniofacial congenital anomalies and is most common in the orofacial region. The incidence of this congenital anomaly in newborn babies is around 15%. Although the pathogenesis of these congenital malformations is not fully known, there is evidence that both dietary and genetic factors play a role, and this evidence is increasing day by day. Children with cleft lip and/or palate may be malnourished after birth due to nutritional difficulties. Children with these deformities are often impaired in growth compared to healthy children. A multidisciplinary approach is mandatory for the evaluation of these babies. Feeding newborns with cleft lip and/or palate in the beginning is a major concern for parents. Nutritional interventions such as breastfeeding, modified bottles and/or nipple, occlusive pads and maternal counseling and support are needed, so this article aims to review some nutritional issues and adaptations in this regard