Evaluation of anti-fungal activity derivative from Premna odorata Blanco extract by deep eutectic solvents

Fungal organisms are an opportunistic pathogen commonly found in different parts in human body like oral cavity and vagina. Recent study has revealed a critical need for novel antifungal medicines developed from medicinal plant extracts due to concerns about fungal pathogen resistance to commercial medication. In the present work, Premna odorata Blanco, belonging to the family Lamiaceae was evaluated in vitro antifungal activity against two fungal organism isolated from clinical cases. With the aim to replace toxic conventional solvents through deep eutectic solvents was used and phytochemical compounds were determined (total phenol content, total flavonoid content). ChMa extracts of Premna odorata Blanco demonstrate a significant antifungal activity against Candida albicans, Monilinia spp. Higher than water extract. While the DES2 extract reported the highest phenolic contents (3.58 mg GAE/100 g DW) and total flavonoid content (0.028 mg RE/100 g DW) compared with water extract. In conclusion, the study suggests that the Premna odorata Blanco extracts by deep eutectic solvents are promising for the development of treatments against various fungal diseases with a friendly green procedure, low toxicity and new application in pharmaceutical industry

Readiness in implementing teacher training programmes based on industrial revolution 4.0: evidence from Malaysian public universities

Since its introduction, the concept of Industrial Revolution 4.0 has received massive intention all around the world. Subsequently, this revolution has brought changes in all fields including higher education. Various propositions have been made towards transforming educational settings parallel with the elements of industrial revolution 4.0. However, there are different reactions from educators regarding this transformation. This study aimed to identify the readiness of educators to implement the elements of industrial revolution 4.0 in Teacher Training Programs in Malaysian Public Universities. The respondents involved in this study consisted of 61 lecturers from 14 public universities in Malaysia. Logit value analysis using Rasch Measurement Analysis found that the respondents’ readiness towards the implementation was at a moderate level (logit = 0.156). Specifically, respondents had a higher level of readiness to implement the constructs related to teaching methods as compared to the constructs related to the implementation methods. Overall, it was found that the lecturers’ readiness to implement elements of IR 4.0 was still at a moderate level. Thus, there should be efforts to apply elements of industrial revolution 4.0 in higher education to equip our future teachers with the skills and knowledge for them to impart to the future generation

Collateral Circulation Characteristic Based on Cone Beam Computed Tomography (Cbct) Images in Hyperacute Stroke

Good collateral circulation flow is a promising outcome for ischemic stroke patients. Collateral circulation is the vessels that flow in parallel to each other, perfusing the same target tissue. Different patients are shown to have different statuses of collateral. Good collateral circulation is expected to give significantly better clinical outcomes for stroke patients including acute stroke patients who underwent thrombectomy. Modern multimodal imaging techniques have encouraged neuroradiology to assess collateral flow. This paper presents the basic overview of CBCT technology and compares the usefulness of Cone Beam Computed Tomography (CBCT), Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) based on working principles, performance, cost and applications. In addition, the overview of collateral circulation and its characteristics will be discussed. In assessing collateral circulation, improvement of acquisition techniques and algorithm CBCT provides fast delineation of detail vasculature and improves spatial resolution. It is a threedimensional (3D) imaging modality to investigate collateral flow. For ischemic stroke patients with clinical symptoms, CBCT improves the image quality for the assessment of collateral circulation in the brain. Precise evaluation of collateral circulation from the images will support the decision-making for suitable acute stroke treatment, benefiting both the patient and doctor. ASEAN Journal of Psychiatry, Vol. 23(10) October, 2022; 1-0