1 research outputs found
Aza-PNA: Engineering E‑Rotamer Selectivity Directed by Intramolecular H‑bonding
No full textThe
replacement of α(CH2) by NH in monomers
of
standard aeg PNA and its homologue β-ala PNA leads to respective aza-PNA monomers
(1 and 2) in which the NαH can form either an 8-membered H-bonded ring with folding of the
backbone (DMSO and water) or a 5-membered NαHαCO
(water) to stabilize E-type rotamers. Such aza-PNA oligomers with exclusive E rotamers
and intraresidue backbone H-bonding can modulate its DNA/RNA binding
and assembling properties
