Attitude towards psychiatric treatment and referral pattern in the University of Maiduguri Teaching Hospital- A preliminary report

Objective: There is a paucity of literature on consultation-liaison psychiatry, in northern Nigeria. This study aimed to determine both the pattern of psychiatric referrals, and the attitudes of doctors toward the treatment of mental disorders in a teaching hospital, in northeast Nigeria. Method: In this cross-sectional survey, we used a modified version of the self-rated Kumar 12-item questionnaire and a basic socio-demographic questionnaire to assess a non-random convenient sample of 100 postgraduate resident doctors (with a response rate of 70%) from the University of Maiduguri Teaching Hospital (UMTH). We subjected the dataobtained to descriptive statistical analysis, using EPI info (2003), to report averages. Results: A relatively low percentage (57.1%) of doctors acknowledged treating patients with mental disorders in their practice, with a higher proportion acknowledging referral (75%). Nearly one in five (17.6%) of the respondents were unaware that patients with functional illness could have psychological disorders. We found more awareness for psychotherapy (44.1%) than other non-pharmacological treatment interventions, while10.3% were ignorant of non-pharmacological forms of treatment for psychological problems. Conclusion: Although this is a preliminary report, the research reported here demonstrated that doctors in the teaching hospital concerned recognized the need for psychiatric consultation and referral. It is difficult to draw further conclusions because of the limitations of this study.Keywords: Consultation; Liaison; Psychiatry; northern Nigeri

Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila pneumoniae Infected Human Mononuclear Cells

Chlamydophila pneumoniae causes acute respiratory tract infections and has been associated with development of asthma and atherosclerosis. The production of IL-1β, a key mediator of acute and chronic inflammation, is regulated on a transcriptional level and additionally on a posttranslational level by inflammasomes. In the present study we show that C. pneumoniae-infected human mononuclear cells produce IL-1β protein depending on an inflammasome consisting of NLRP3, the adapter protein ASC and caspase-1. We further found that the small GTPase Rac1 is activated in C. pneumoniae-infected cells. Importantly, studies with specific inhibitors as well as siRNA show that Rac1 regulates inflammasome activation in C. pneumoniae-infected cells. In conclusion, C. pneumoniae infection of mononuclear cells stimulates IL-1β production dependent on a NLRP3 inflammasome-mediated processing of proIL-1β which is controlled by Rac1

Identification of neural networks that contribute to motion sickness through principal components analysis of fos labeling induced by galvanic vestibular stimulation

Motion sickness is a complex condition that includes both overt signs (e.g., vomiting) and more covert symptoms (e.g., anxiety and foreboding). The neural pathways that mediate these signs and symptoms are yet to identified. This study mapped the distribution of c-fos protein (Fos)-like immunoreactivity elicited during a galvanic vestibular stimulation paradigm that is known to induce motion sickness in felines. A principal components analysis was used to identify networks of neurons activated during this stimulus paradigm from functional correlations between Fos labeling in different nuclei. This analysis identified five principal components (neural networks) that accounted for greater than 95% of the variance in Fos labeling. Two of the components were correlated with the severity of motion sickness symptoms, and likely participated in generating the overt signs of the condition. One of these networks included neurons in locus coeruleus, medial, inferior and lateral vestibular nuclei, lateral nucleus tractus solitarius, medial parabrachial nucleus and periaqueductal gray. The second included neurons in the superior vestibular nucleus, precerebellar nuclei, periaqueductal gray, and parabrachial nuclei, with weaker associations of raphe nuclei. Three additional components (networks) were also identified that were not correlated with the severity of motion sickness symptoms. These networks likely mediated the covert aspects of motion sickness, such as affective components. The identification of five statistically independent component networks associated with the development of motion sickness provides an opportunity to consider, in network activation dimensions, the complex progression of signs and symptoms that are precipitated in provocative environments. Similar methodology can be used to parse the neural networks that mediate other complex responses to environmental stimuli. © 2014 Balaban et al

Structural development of vegetation on rehabilitated North Stradbroke Island: Above/belowground feedback may facilitate alternative ecological outcomes

Introduction: This study depicts broad-scale revegetation patterns following sand mining on North Stradbroke Island, south-eastern Queensland, Australia. Methods: Based on an ecological timeline spanning 4-20 years post-rehabilitation, the structure of these ecosystems (n = 146) was assessed by distinguishing between periods of 'older' (pre-1995) and 'younger' (post-1995) rehabilitation practices. Results: The general rehabilitation outlook appeared promising, whereby an adequate forest composition and suitable levels of native biodiversity (consisting of mixed-eucalypt communities) were achieved across the majority of rehabilitated sites over a relatively short time. Still, older sites (n = 36) appeared to deviate relative to natural analogues as indicated by their lack of under-storey heath and simplified canopy composition now characterised by mono-dominant black sheoak (Allocasuarina littoralis) reaching up to 60% of the total tree density. These changes coincided with lower soil fertility parameters (e.g., total carbon, total nitrogen, and nutrient holding capacity) leading us to believe that altered growth conditions associated with the initial mining disturbance could have facilitated an opportunistic colonisation by this species. Once established, it is suspected that the black sheoak's above/belowground ecological behaviour (i.e., relating to its leaf-litter allelopathy and potential for soil-nitrogen fixation) further exacerbated its mono-dominant distribution by inhibiting the development of other native species. Conclusions: Although rehabilitation techniques on-site have undergone refinements to improve site management, our findings support that putative changes in edaphic conditions in combination with the competitive characteristics of some plant species can facilitate conditions leading to alternative ecological outcomes among rehabilitated ecosystems. Based on these outcomes, future studies would benefit from in depth spatio-temporal analyses to verify these mechanisms at finer investigative scales