Serum level of interleukin-6 in patients with oral tongue squamous cell carcinoma

Introduction: The clinical outcome of patients with squamous cell carcinoma (SCC) located in the head and neck has remained poor despite ongoing advances in diagnosis and management. Interleukin-6(IL-6) is a multi-functional cytokine that plays an important role in the process of cell differentiation and is increased in several malignancies. The aim of this study was to investigate the serum levels of interleukin-6 in patients with oral tongue SCC. Materials and Methods: In a cross-sectional study, 17 patients with oral tongue SCC were compared with the same number of age- and gender-matched healthy subjects. Serum IL-6 level fluctuation was determined using an immunological technique, before detecting its possible association with the subjects' age, gender, drinking and smoking history, cancer site, and disease severity. Results: The intensity of serum IL-6 in patients with oral tongue SCC was statistically significantly higher than that in healthy subjects (P<0.001). Serum IL-6 level was independent of the patients' age, gender, smoking and drinking history as well as cancer stage. Conclusion: IL-6 is a valuable biomarker in the diagnosis of oral tongue SCC. Its high sensitivity makes prediction of this condition possible, while this biomarker can also be used to screen high-risk patients

Serum level of interleukin-6 in patients with oral tongue squamous cell carcinoma

Introduction: The clinical outcome of patients with squamous cell carcinoma (SCC) located in the head and neck has remained poor despite ongoing advances in diagnosis and management. Interleukin-6(IL-6) is a multi-functional cytokine that plays an important role in the process of cell differentiation and is increased in several malignancies. The aim of this study was to investigate the serum levels of interleukin-6 in patients with oral tongue SCC. Materials and Methods: In a cross-sectional study, 17 patients with oral tongue SCC were compared with the same number of age- and gender-matched healthy subjects. Serum IL-6 level fluctuation was determined using an immunological technique, before detecting its possible association with the subjects' age, gender, drinking and smoking history, cancer site, and disease severity. Results: The intensity of serum IL-6 in patients with oral tongue SCC was statistically significantly higher than that in healthy subjects (P<0.001). Serum IL-6 level was independent of the patients' age, gender, smoking and drinking history as well as cancer stage. Conclusion: IL-6 is a valuable biomarker in the diagnosis of oral tongue SCC. Its high sensitivity makes prediction of this condition possible, while this biomarker can also be used to screen high-risk patients

Survey of postoperative hemorrhage after tonsillectomy and adenoidectomy in children

Introduction: Tonsillectomy, with or without adenoidectomy, is the most common surgical operations which is performing in the field of ear, pharynx and nose. The most common serious complication following tonsillectomy is postoprative hemorrhage that it could threat patient’s life and occurs intraoperatively, immediate postoperatively (within 24 hours post-operation) or delayed (24 hours after operation). Materials and Methods: The current survey was a cross- sectional study, which performed according to the records of patients who had an adenotonsillectomy and involved with hemorrhage after the surgery in Tabriz children hospital from April 1999 to June 2002. In addition, the patients were needed for a surgery with general anesthesia to control the hemorrhage. Results: Postoperative hemorrhage was observed in 17 out of total 1107 patients (1.53%) and the most common indication of surgery was both infective and obstructive causes. 94.1% of these patients involved with primary hemorrhage and the cause of hemorrhage was disorder in hemostasis in 70.6 % of patients. The most common ages of hemorrhage was 8 and 12. Conclusion: By establishment of exact hemostasis following surgery and the control of tansillar fossa and nasopharynx for remaining tissues, hemorrhage could be decreased. In addition, the rate of mortalily after surgery could be significantly decreased by the control of patients for the first 24 hours after surgery, that it says, the control of vital signs and tonsillar fossa for probability of hemorrhage and its treatment