New eco-friendly procedure for the synthesis of 4-arylmethylene-isoxazol-5(4<i>H</i>)-ones catalyzed by pyridinium <i>p</i>-toluenesulfonate (PPTS) in aqueous medium

<p>In this work we describe a new, highly efficient method for the synthesis of 3-methyl-4-arylmethylidene-isoxazol-5(4H)-one derivatives by a three-component reaction between aromatic aldehydes, ethyl acetoacetate, and hydroxylamine hydrochloride under the influence by PPTS as a low-toxicity, inexpensive, commercially available and easy to handle catalyst. The advantages of this procedure are good yields, short reaction times, simplicity of implementation, and respect of the environment.</p

Solvent-free synthesis of polyhydroquinoline and 1,8-dioxodecahydroacridine derivatives through the Hantzsch reaction catalyzed by a natural organic acid: A green method

<p>Solvent-free and high yielding one-pot synthesis of 1,8-dioxodecahydroacridine and polyhydroquinoline derivatives have been described through Hantzsch condensation of various aldehydes, ammonium acetate with cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate in a very simple, efficient, and environmentally benign method using ascorbic acid as a nontoxic organocatalyst.</p

Synthesis, Biological Evaluation, DFT Calculations and Molecular Docking of 5-Arylidene-Thiazolidine-2,4-Dione Derivatives

A simple and rapid procedure is developed for the synthesis of 5-arylidene-thiazolidine-2,4-dione derivatives by the Knoevenagel reaction between a variety of aromatic aldehydes and thiazolidine-2,4-dione, catalyzed by N,N-dimethylaminopyridine. The reactions were carried out without solvent giving excellent yields of the expected products. The antioxidant activity of all the molecules prepared was evaluated and two of them gave encouraging results. In addition, an extensive theoretical study was carried out such as density functional theory (DFT) calculations, theoretical predictions of biological activities and molecular docking.</p