Correspondence analysis showing a global view of the relationship among Mediterranean populations according to HLA allele frequencies in three dimensions (bi-dimensional representation).

<p>HLA-DRB1 allele frequencies data. Only individuals with defined DRB1 subtypes are considered.</p

HLA Class I and Class II two-Locus haplotypes in Tunisians.

<p>HLA Class I and Class II two-Locus haplotypes in Tunisians.</p

The closest populations to Arabs using standard genetic distances (SGD) based on <i>HLA-DRB1*</i> alleles.

<p>The closest populations to Arabs using standard genetic distances (SGD) based on <i>HLA-DRB1*</i> alleles.</p

The most frequent (%) <i>HLA</i> extended haplotypes in Arabs.

<p>The most frequent (%) <i>HLA</i> extended haplotypes in Arabs.</p

Most frequent <i>HLA-A*</i> and–<i>B*</i> alleles in Arab populations.

<p>Most frequent <i>HLA-A*</i> and–<i>B*</i> alleles in Arab populations.</p

Most frequent <i>HLA-DRB1*</i> and–<i>DQB1*</i> alleles in Arab populations.

<p>Most frequent <i>HLA-DRB1*</i> and–<i>DQB1*</i> alleles in Arab populations.</p

Neighbor-Joining dendrogram showing relatedness between Tunisians and other populations.

<p>Standard genetic distances (SGD) between populations were calculated by using generic HLA-DRB1 and -DQB1 genotyping. Data from other populations were taken from references detailed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0136909#pone.0136909.t001" target="_blank">Table 1</a>. Bootstrap values from 1.000 replicates are shown.</p

Standard genetic distances (SGD¹) between Tunisians and other populations.

<p>^1. Obtained by using HLA-DRB1 allele frequencies.</p><p>^2. Refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0136909#pone.0136909.t001" target="_blank">Table 1</a> for profile of populations studied.</p><p>Standard genetic distances (SGD<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0136909#t003fn001" target="_blank">¹</a>) between Tunisians and other populations.</p

Most frequent HLA four- loci haplotypes in Tunisians.

<p>Most frequent HLA four- loci haplotypes in Tunisians.</p

Correspondence analysis (bi-dimensional representation), based on the standard genetic distances, showing a global view of the relationship among Arabs and other populations according to generic <i>HLA*-A</i> and–<i>B*</i> allele frequencies data.

<p>Populations data were taken from references detailed in Tables <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0192269#pone.0192269.t001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0192269#pone.0192269.t002" target="_blank">2</a>.</p