Patterns of failure following post-operative intensity-modulated radiotherapy in oral cavity cancer: Planning CT and Recurrence CT dataset

<p><i>Purpose of Original Study</i></p><p>We sought to identify spatial/dosimetric patterns of failure for oral cavity cancer (OCC) patients receiving post-operative intensity-modulated radiotherapy (PO-IMRT).</p><p><i>Material and Methods</i></p><p>289 OCC patients receiving PO-IMRT from a single institution were retrospectively reviewed from 2000-2012 with institutional review board approval. Diagnostic CT/PET-CT documenting recurrence (rCT) was co-registered with original planning CTs (pCT) using a validated deformable image registration (DIR) workflow. Manually segmented recurrent gross disease (rGTV) on rCT was deformed to co-registered pCTs. Mapped rGTVs were compared dosimetrically to planned dose and spatially to original planning target volumes (TVs) using centroid-based approaches. Technical details for the DIR workflow methodology are found in the references below.</p><p>We classify failure using standardized institutional classification system combining spatial/dosimetric criteria: A (central high dose), B (peripheral high dose), C (central elective dose), D (peripheral elective dose), and E (extraneous dose). Definitions of failure classifications are further described in the references below. Of 63 patients with locoregional recurrences, 48 patients had available rCT and pCT for analysis. In this dataset of 48 patient rCTs, 75 rGTVs were identified.</p><p><i>Purpose of Sharing Anonymized Dataset</i></p><p>We hope that by utilizing a standardized typology for reporting patterns of failure in OCC following PO-IMRT, which can be adopted by multiple institutions, we can encourage other comparable reporting practices for PO-IMRT, in a manner that allows improved detection of possible modes of preventable error; for this reason, we are posting an anonymized archive of the extant dataset via digital repository.</p><p>In this anonymized fileset in DICOM format, we share the following:</p><p>1. Original pCTs of 48 patients, along with original planning TVs</p><p>2. Prescribed dose to original pCTs</p><p> </p><p>3. rCTs of 48 patients, along with the 75 rGTVs</p

Additional file 1: Table S1. of Methodology for analysis and reporting patterns of failure in the Era of IMRT: head and neck cancer applications

IMRT target volume definitions and dose prescription. Table S2. Dosimetric patterns of failure. (DOCX 16 kb

Additional file 1:Tables S1 and S2. of Patterns of locoregional failure following post-operative intensity-modulated radiotherapy to oral cavity cancer: quantitative spatial and dosimetric analysis using a deformable image registration workflow

Showing our study’s patient/treatment and failure characteristics compared to extant literature. (PDF 99 kb

Additional file 1: Table S1. of Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients ≥65 years old

Proportions of patients reporting moderate to severe (≥5) rating for the 22 MDASI-HN symptom items by clinical subgroups of interest. (DOCX 20 kb