Structural Chemistry of Several Compounds Elucidated by Single Crystal X-Ray Diffraction.

The single crystal X-ray diffraction structure of four compounds have been determined. Crystals of bis((mu)-acetato-O:O\u27)-bis 4\u27-nitro-2\u27-(2-pyridyl)phenyl-N dipalladium (II), (PdC(,13)H(,10) N(,2) O(,4))(,2), are monoclinic, space group I 2/c, with lattice constants: a = 14.300(3)(ANGSTROM), b = 9.939(1)(ANGSTROM), c= 18.822(2)(ANGSTROM), (beta) = 91.01(3)(DEGREES). The structure was solved by the heavy atom technique, and full-matrix least squares refinement resulted in a final R-value of 0.029, Rw = 0.050. The molecule has a folded conformation with Pd---Pd = 2,822(6)(ANGSTROM). Crystals of pseudo penta-O-acetyl-(beta)-D,L-Glucopyranose are monoclinic, space group P2(,1)/c, a = 11.580(2)(ANGSTROM), b = 8.276(1)(ANGSTROM), c = 22.031(2)(ANGSTROM), (beta) = 104.33(1)(DEGREES). The structure was solved by direct methods and refined to a final R value of 0.049 and Rw of 0.054. The pseudo-glucose ring has nearly a (\u274)C(,1) conformation with O(61) in the gg position. Ba (Pt(,x), Ni(,1-x))(CN)(,4) .4H(,2)O crystallizes in space group C2/c with lattice constants: a = 12.209(2)(ANGSTROM), b = 13.752(2)(ANGSTROM), c = 6.638(1)(ANGSTROM) and (beta) = 107.76(1)(DEGREES). The disordered structure consists of columns of M(CN)(,4)(\u272-) groups (M = Pt and Ni) stacked along the c axis with M-M distance of 3.319(1)(ANGSTROM). Planes of these groups are tilted by 4.1(1)(DEGREES) from the c axis. The CN(\u27-) ligands are found to be staggered with NC - M - M - CN torsion angles ranging from 42(DEGREES) to 48(DEGREES). The Ba(\u272+) ion has a ten fold coordination of bicapped square antiprismatic geometry. The crystal structure refined to R = 0.0469, Rw = 0.0699, and X = 0.59. 2,5-anhydro-(1,3,4,6-O-(\u272)H(,4))-D-Mannitol crystallizes in space group P2(,1)2(,1)2(,1) with a = 7.876(1)(ANGSTROM), b = 8.561(1)(ANGSTROM), c = 11.443(1)(ANGSTROM). The molecule does not have the expected C(,2) symmetry: the ring C - O bonds are unequal in length, and the conformation is slightly distorted from the ideal (\u274)T(,3) configuration

Bone regeneration using deproteinized bovine bone mineral (DBBM) in a crestal sinus elevation technique: a histological and histomorphometrical pilot study

The aim of this study is to evaluate the percentage of new bone formation (NBF) and residual bone substitute following the use of a bovine demineralized xenograft (DBBM) in a sinus floor crestal approach elevation technique

Dehydro­leucodin: a guaiane-type sesquiterpene lactone

Dehydro­leucodin [systematic name: (1S,6S,2R)-9,13-dimeth­yl-5-methyl­ene-3-oxatricyclo­[8.3.0.02,6]trideca-9,12-diene-4,11-dione], C15H16O3, is a guanolide isolated from Artemisia douglasiana. The fused-ring system contains a seven-membered ring that adopts a chair conformation, a fused planar cyclo­pentenone ring and a five-membered lactone ring fused in envelope conformation. The absolute structure determined by X-ray analysis agrees with that previously assigned to this compound by NMR studies [Bohlmann & Zdero (1972 ▶). Tetra­hedron Lett. 13, 621–624] and also with that of leucodine, a closely related guaianolide [Martinez et al. (1988 ▶). J. Nat. Prod. 51, 221–228]

Disclosure of Diagnosis and Prognosis to Cancer Patients in Traditional Societies: A Qualitative Assessment from Lebanon

Background: The issue of when, how, and whether to disclose full information about cancer diagnosis and prognosis to patients is still debated in some parts of the world, including Lebanon. Despite formal academic emphasis on a larger autonomy for Lebanese patients in deciding the course of their disease, there has been no apparent impact on either clinical practices nor public expectations.  The topic of full disclosure is rarely if ever discussed in open fora, or in mass media channels in Lebanon. Subjects and Method: Seven key stakeholders were identified and interviewed regarding obstacles to spelling out clear guidelines within our national context. The interviews were transcribed and subsequently analyzed for recurrent patterns and concepts.Results: Senior oncologists interviewed generally favored gradual disclosure and most perceived a changing trend among both patients and physicians towards more disclosure. They also agreed on a need for the formal training of residents and fellows to better communicate bad news to patients. All the interviewed physicians attested to the benefits of candid disclosure in terms of patient psychology and overall wellbeing. They also mentioned that psychological services, which may facilitate the disclosure process, are greatly under-utilized in oncology. Lawyers highlighted the vagueness of the current Lebanese legislation regarding the obligation of truthful disclosure in comparison to laws in developed countries and the implications on patient autonomy. Conclusion: The study identified the need for improvements at various levels, including interventions to modify the expectations of the Lebanese public regarding cancer disclosure and to clarify existing legislative texts.Keywords: Ethics; Legislation; Middle-East; DisclosureCorrespondence: James Feghali. Faculty of Medicine, American University of Beirut (AUB), Lebanon, 1101 North Calvert Street, 610, Baltimore, Maryland, 21202. E-mail: [email protected]. Telephone: +1-(267)-595-9995.Journal of Epidemiology and Public Health (2019), 4(2): 109-116https://doi.org/10.26911/jepublichealth.2019.04.02.0

A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer

<p>Abstract</p> <p>Purpose/Objective</p> <p>This is a prospective comparison of weekly cisplatin to weekly paclitaxel as concurrent chemotherapy with standard radiotherapy for locally advanced cervical carcinoma.</p> <p>Materials/Methods</p> <p>Between May 2000 and May 2004, 31 women with FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence were enrolled into this phase II study and randomized to receive on a weekly basis either 40 mg/m²Cisplatin (group I; 16 patients) or 50 mg/m²paclitaxel (group II; 15 patients) concurrently with radiotherapy. Median total dose to point A was 74 Gy (range: 66-92 Gy) for group I and 66 Gy (range: 40-98 Gy) for group II. Median follow-up time was 46 months.</p> <p>Results</p> <p>Patient and tumor characteristics were similar in both groups. The mean number of chemotherapy cycles was also comparable with 87% and 80% of patients receiving at least 4 doses in groups I and II, respectively. Seven patients (44%) of group I and 8 patients (53%) of group II developed tumor recurrence. The Median Survival time was not reached for Group I and 53 months for group II. The proportion of patients surviving at 2 and 5 years was 78% and 54% for group I and 73% and 43% for group II respectively.</p> <p>Conclusions</p> <p>This small prospective study shows that weekly paclitaxel does not provide any clinical advantage over weekly cisplatin for concurrent chemoradiation for advanced carcinoma of the cervix.</p

Di-&#956;-azido-diazidodi-&#956;-oxalato-dihistaminetetracopper(II) 0.9-hydrate

The title compound, [Cu4(C2O4)2(N3)4(C5H9N3)2]&#183;0.9H2O, contains a tetranuclear CuII-based molecule composed of two oxalate-bridged CuII dimers linked through end-on azide ions and related by an inversion center. The tetranuclear unit contains two crystallographically independent CuII ions. One CuII ion coordinates to two N atoms of a histamine molecule, two O atoms of a bridging oxalate ligand, and an N atom of an end-on bridging azide ligand, leading to an elongated square-pyramidal coordination geometry in which the azide ion occupies the axial position. The other CuII ion, which has a square-planar coordination geometry, is coordinated by two O atoms of a bridging oxalate ligand and two N atoms of two different azide ligands, one which is bridging. In the crystal, a two-dimensional network parallel to (010) is formed by N&#8212;H...N and N&#8212;H...O hydrogen bonds. A partially occupied solvent water molecule refined to an occupancy of 0.447&#8197;(5). Two of the azide ligands were refined as disordered over two sets of sites with refined occupancies in the ratios 0.517&#8197;(8):0.483&#8197;(8) and 0.553&#8197;(5):0.447&#8197;(5)