Politique numéro 5 concernant le code d’éthique et de déontologie des membres du Conseil d’administration

Disponible en anglais dans EDUQ.info sous le titre "Policy no. 5 Concerning Code of Ethics and Professional Conduct for Members of Board of Governors

The distribution of cirripeds and gastropods on plain vertical rock surfaces in the upper intertidal and splash zones

This is a student paper done for a University of California Berkeley Zoology class. Since UCB didn't have its own marine lab at the time, it rented space at Hopkins Marine Station where this work was done. Cadet Hand earned his Ph.D. from Berkeley and went on to become Director of the Bodega Marine Laboratory. Donald Putnam Abbott also earned his Ph.D. from Berkeley and later became a Stanford professor at Hopkins Marine Station. (PDF contains 26 pages

Thinning out redundant empirical data

Given a set $X$ of "empirical" points, whose coordinates are perturbed by errors, we analyze whether it contains redundant information, that is whether some of its elements could be represented by a single equivalent point. If this is the case, the empirical information associated to $X$ could be described by fewer points, chosen in a suitable way. We present two different methods to reduce the cardinality of $X$ which compute a new set of points equivalent to the original one, that is representing the same empirical information. Though our algorithms use some basic notions of Cluster Analysis they are specifically designed for "thinning out" redundant data. We include some experimental results which illustrate the practical effectiveness of our methods.Comment: 14 pages; 3 figure

Stable Border Bases for Ideals of Points

Let $X$ be a set of points whose coordinates are known with limited accuracy; our aim is to give a characterization of the vanishing ideal $I(X)$ independent of the data uncertainty. We present a method to compute a polynomial basis $B$ of $I(X)$ which exhibits structural stability, that is, if $\widetilde X$ is any set of points differing only slightly from $X$, there exists a polynomial set $\widetilde B$ structurally similar to $B$, which is a basis of the perturbed ideal $I(\widetilde X)$.Comment: This is an update version of "Notes on stable Border Bases" and it is submitted to JSC. 16 pages, 0 figure

Control of flow separation and mixing by aerodynamic excitation

The recent research in the control of shear flows using unsteady aerodynamic excitation conducted at the NASA Lewis Research Center is reviewed. The program is of a fundamental nature, concentrating on the physics of the unsteady aerodynamic processes. This field of research is a fairly new development with great promise in the areas of enhanced mixing and flow separation control. Enhanced mixing research includes influence of core turbulence, forced pairing of coherent structures, and saturation of mixing enhancement. Separation flow control studies included are for a two-dimensional diffuser, conical diffusers, and single airfoils. Ultimate applications include aircraft engine inlet flow control at high angle of attack, wide angle diffusers, highly loaded airfoils as in turbomachinery, and ejector/suppressor nozzles for the supersonic transport. An argument involving the Coanda Effect is made that all of the above mentioned application areas really only involve forms of shear layer mixing enhancement. The program also includes the development of practical excitation devices which might be used in aircraft applications

The Cost of US Pharmaceutical Price Reductions: A Financial Simulation Model of R&D Decisions

Previous empirical studies that have examined the links between pharmaceutical price controls, profits, cash flows, and investment in research and development (R&D) have been largely based on retrospective statistical analyses of firm- and/or industry-level data. These studies, which have contributed numerous insights and findings to the literature, relied upon ad hoc reduced-form model specifications. In the current paper we take a very different approach: a prospective micro-simulation approach. Using Monte Carlo techniques we model how future price controls in the U.S. will impact early-stage product development decisions in the pharmaceutical industry. This is done within the context of a net present value (NPV) framework that appropriately reflects the uncertainty associated with R&D project technical success, development costs, and future revenues. Using partial-information estimators calibrated with the most contemporary clinical and economic data available, we demonstrate how pharmaceutical price controls will significantly diminish the incentives to undertake early-stage R&D investment. For example, we estimate that cutting prices by 40 to 50 percent in the U.S. will lead to between 30 to 60 percent fewer R&D projects being undertaken (in early-stage development). Given the recent legislative efforts to control prescription drug prices in the U.S., and the likelihood that price controls will prevail as a result, it is important to better understand the firm response to such a regulatory change.

Annual Report /

2014-2015